Onsite Session

*Session Numbers:
Date + AM/PM (A/P) + Symposium (S) + - (hyphen) + Room
(ex.) 3PS-05: Day 3, PM, Room 05

*Time:
9:30-11:45, (PM) 16:00-18:15

*Language：
E English　J Japanese

*Onsite sessions will not be live-streamed or available for on-demand viewing.

Extinct Species and New Generation Technologies

organizer
Kazuo Yamagata (Kindai University), Katsuhiko Hayashi (Osaka University)

Detail

Science fiction has told the dream of reviving extinct organisms through imaginary technologies. Real-world technologies, though not far behind, have been utilized not only in the conservation of endangered species but also in breeding, reproduction, and reproductive medicine. Meanwhile, recently, the technologies such as pluripotent stem cells, germ cell induction, and genetic engineering have seen dramatic advances. This symposium will bring together researchers who are developing the latest technologies and aiming to conserve and revive endangered species to discuss the future challenges.

Critics for Phasing Biology to reinforce the fundamental parts: deep understandings from pure and applied viewpoints about droplets

organizer
Tomohiro Nobeyama (University of Tsukuba), Natsuko Miura (Osaka Metropolitan University)

Detail

Liquid-liquid phase separation(LLPS) of bio-macromolecule has gathered various attention. LLPS is a phenomenon that bio-macromolecules, such as DNA or protein form liquid phases under suitable conditions and form sphere shape reaction fields called droplets. Sophisticated behaviors of cells have been analyzed from the viewpoint of LLPS and these have caused an emergence of a new topic called “Phasing Biology". On the other hand, although versatile research has revealed the externalistic interesting phenomenon, a deep understanding of droplets themselves and how to interpret observation of droplets have tended to be left. In this symposium, we are going to clarify equivocal and/or overlooked points about phasing biology from the biological and physical scientists' opinions and discuss the topics with engineering knowledge of droplet manipulations. We aim to reinforce the fundamental parts of Phasing Biology with the integration of the multidimensional experiences both of droplet analysis and creation.

Emergence of multicellular autonomy
Co-hosted by: Grant-in-Aid for Transformative Research Areas(A)"Multicellular Autonomy"

organizer
Tetsuhisa Otani (National Institute for Physiological Sciences), Tsuyoshi Hirashima (National University of Singapore)

Detail

Multicellular organisms have the remarkable ability to organize and optimize its structure and functions autonomously. Multicellular autonomy is achieved despite external perturbations and internal variation, and emerging evidence suggests that such noise and variation can be eliminated over time via intercellular communication. In this symposium, we will discuss the mechanisms underlying multicellular autonomy in a multidisciplinary manner.

Epigenetic dynamism and cancer development

organizer
Atsushi Kaneda (Chiba University), Yutaka Kondo (Nagoya University)

Detail

Cancer changes dynamically due to various external factors. Multifaceted and comprehensive analyses of cancer cells themselves and their surrounding environment e.g. fibroblasts and immune cells have clarified highly plastic epigenetic dysregulation critical for cancer development. Abundant advanced researches are conducted in this field so that high level discussion is expected in this session.

Uncovering the multidimensional information that controls cell fate

organizer
Naoko Hattori (Hoshi University), Haruna Takeda (National Cancer Center )

Detail

Cell fate largely depends on the signals received from the microenvironment. How the microenvironment alters the fate of target cells during the processes of development, cell differentiation, and cancer development remains largely unknown. In this symposium, we will focus on the state-of-the-art findings using new approaches, such as advanced animal models, organoids, omics analysis, and mathematical models, and discuss how we can create new insights and elucidate the mechanisms of disease progression.

Aging Research from the Viewpoint of Extracellular Matrix

organizer
Yukimasa Shibata (Kwansei Gakuin University), Shinji Ihara (Prefectural University of Hiroshima)

Detail

The extracellular matrix (ECM) not only maintains the shape of cell populations, but also acts as a dynamic signal source. Although it has been known that the ECM changes with aging, it has recently become clear that the ECM regulates the aging process. In this symposium, we would like to discuss the role of ECM in aging and homeostasis in individuals and tissues.

Dysregulation of Protein/RNA Homeostasis in Neuronal Function - From Neurogenesis to Neuropathology -

organizer
Norifumi Shioda (Kumamoto University), Satoru Morimoto (Keio University)

Detail

A number of gene mutations of RNA-binding proteins (RBPs) have been identified in neurodegenerative diseases. In addition, the aggregation of RBPs has been observed in the brains of these patients. Furthermore, RBPs have been shown to play an important role in the development of neurons, suggesting that "dysfunction of protein/RNA homeostasis" is a key to elucidate neuronal functions and pathophysiology. In this symposium, we aim to comprehensively understand the mechanism of the disruption of protein/RNA homeostasis in neurons, and will present a wide range of lectures from neurogenesis to neuropathology.

The expanding field of DNA damage response

organizer
Takaaki Yasuhara (Kyoto University), Atsushi Shibata (Keio University)

Detail

Genome stability is essential for the maintenance of homeostasis. Recent advances in experimental techniques have revealed more detailed molecular mechanisms of the DNA damage response (DDR) and its relationship to disease phenotypes in clinic. In this symposium, we will first discuss the latest findings on the mechanisms of DDR. Furthermore, given that DDR is the fundamental mechanism in many other related fields, such as transcription, aging, and cancer, we would like to invite rising researchers in those fields and discuss the future overlook of the field of DDR.

Advanced research tools approaching machinery and condensates assembled with ncRNAs

organizer
Tetsuro Hirose (Osaka University), Toshie Kai (Osaka University)

Detail

Elucidation of noncoding (nc)RNA functions is an important issue in the post-genomic era. Since ncRNAs form RNP complexes and phase-separated condensates as their operating machinery, research on the mechanism of action of the machinery is crucial for understanding ncRNA functions. This symposium compiles a variety of studies using advanced methods such as single molecule analysis, super-resolution imaging, RADICL-seq, BioID, and synthetic biology, and prospects for future ncRNA research.

Dynamics of genome organization and transcription machineries in gene regulation

organizer
Yuka W.Iwasaki (RIKEN), Takashi Fukaya (The University of Tokyo)

Detail

It is becoming increasingly clear that spatial and temporal specificity of gene expression is highly regulated through the dynamic changes of 3D chromatin organization and the formation of transcriptional condensates during development. However, the biological functions and underlying molecular mechanisms of these processes still remain largely unclear. This symposium will introduce new insights into gene regulation obtained using cutting-edge techniques such as whole-genome analysis and quantitative live-imaging methods.

Multifaceted cellular responses driven by organelle-based recognition and handling of small biomolecules

organizer
Shiori Sekine (University of Pittsburgh), Koji Yamano (Tokyo Medical and Dental University)

Detail

The intracellular dynamics of small biomolecules are monitored by various mechanisms and precisely controlled in response to intra- and extra-cellular environmental changes. This symposium will focus on cutting edge studies that have identified organelles as critical hubs for the recognition and handling of small biomolecules. Domestic and overseas young researchers will share their latest findings on this topic and discuss these detailed molecular mechanisms as well as the multifaceted cellular responses driven by them.

Frontiers in the study of brain development and evolution

organizer
Quan Wu (Kyoto University), Takuma Kumamoto (Tokyo Metropolitan Institute of Medical Science)

Detail

The development of the brain begins with a layer of epithelial cells at the front of the neural tube. These cells proliferate and differentiate into different types of neurons and other supporting cells, such as astrocytes and oligodendrocytes. During the development of the brain, the brain is divided into different regions that will give rise to distinguished functions in the adult brain. Interestingly, the mechanism underlying the generation of different cell types and regions are highly conserved during evolution. However, the molecular basis of this mechanism and how it contributes to the acquisition of higher cognitive function is largely unknown. In this symposium, we will invite the next generation of neuroscientists who have already used new technologies to study brain development and evolution cross different species. We will exchange our views concerning the advantage and limitation of these new technologies and discuss the results we obtained so far.

Cellular and nuclear dynamics that allow accurate genome replication and inheritance

organizer
Tomomi Tsubouchi (National Institutes of Natural Sciences)

Detail

DNA replication is a key phenomenon for life that is conserved across species. While basic principles underlying DNA replication is being elucidated, many questions regarding how it collaborates with other cellular events (e.g., chromosome dynamics, cell cycle regulation) to accomplish accurate genome-wide replication and inheritance, still remains unanswered. In this symposium, we will focus on the cellular and nuclear dynamics during DNA replication and chromosome segregation, and discuss how these are wired to accomplish accurate inheritance of the genome.

Mechanisms of morphogenesis by non-cellular materials
Co-hosted by: Grant-in-Aid for Transformative Research Areas (A) Material properties determine body shapes and their constructions

organizer
Reiko Tajiri (Chiba University), Takeshi Onuma (Kagoshima University)

Detail

Studies on morphogenetic mechanisms have focused on the dynamics of cells, the building blocks of the body. However, the body is not just the sum of cells. It is "non-cellular materials" such as bones, cell walls, exoskeletons, etc. that form and support the bodies of multicellular organisms. How do those non-cellular materials undergo morphogenesis? With speakers who work on this issue using diverse organisms, we discuss the frontiers and future possibilities of the field.

Endogenous viral elements: Let's gather our wisdom for further knowledge!

organizer
Mie Kobayashi-Ishihara (Keio Univeristy), Junna Kawasaki (Waseda University)

Detail

Genetic materials derived from viruses (called endogenous viral elements, EVEs) have been referred to as “junk DNA” for a long time, but we can no longer call them junk now. Recent technological advances unveiled the dual nature of EVEs; they cause diseases as foes, while they provide new functions as friends. This symposium will discuss EVEs’ roles and further potential from broad aspects of the life science fields.

Toward Data-Driven Genome Breeding with Bio-DX
Co-hosted by: The Center of Innovation for Bio-Digital Transformation (BioDX), a program on the open innovation platform for industry-academia co-creation (COI-NEXT)

organizer
Hidemasa Bono (Hiroshima University), Kazuki Nakamae (Hiroshima University)

Detail

BioDX, the life science version of Digital Transformation (DX), has recently been attracting attention, and laboratory automation and the utilization of life science big data are being promoted. However, the trend is still limited. Therefore, this symposium will provide an opportunity to exchange information with pioneers who are practicing BioDX and discuss their own BioDX. The goal is to formulate useful knowledge for each research through discussion.

Diseases involving protein multifunctionality and multiple localization :From basics to diagnosis and treatment

organizer
Kohji Yamada (Jikei University), Taketo Yamada (Saitama Medical University)

Detail

Protein localization defines cellular functions both temporally and spatially, which is an important biological property involved in almost all life phenomena such as development and immunity. Emerging evidence suggests that several proteins exhibiting unexpected localization and multifunctional properties are related to many diseases. In this symposium, we will discuss a wide range of topics from the basics of pathogenesis to diagnosis and treatment.

Uncovering and Controlling the Clock That Sets Tempo for the Development and Regeneration

organizer
Mio Nakanishi (Chiba University) , Mitsuhiro Matsuda (PoL, TU-Dresden)

Detail

Mechanisms underlying temporal regulation of tissue formation largely remain unknown despite their central roles in the embryogenesis and tissue regeneration. In this symposium, we will introduce cutting-edge studies on the biological clocks governing tissue formation/maturation. We will also provide perspectives in this field, including application to regenerative medicine.

Geroscience research from molecular view

organizer
Mitsuo Maruyama (National Center for Geriatrics and Gerontology), Takahiko Shimizu (National Center for Geriatrics and Gerontology)

Detail

With the advent of "the era of the 100-year lifespan,", we have chances to be aware of aging gradually. Through Geroscience research, as a novel research area, which combines the diversity revealed by aging research as well as possesses the universality of life span research, we will introduce leading-edge researches focusing on the control of aging and molecules involved in the aging process. Furthermore, we also discuss the possibility of controlling the onset or progression of aging-related diseases by applying the results to humans, and together we will consider to achieve healthy longevity for each and every one of us.

Molecular networks of DNA replication stress tolerance behind molecular pathology

organizer
Yoko Katsuki (Kyushu University), Bunsho Shiotani (National Cancer Center)

Detail

DNA replication stress is characterized by the slowing or stalling of replication fork progression during DNA synthesis, leading to genomic instability that is intimately associated with various biological processes. In this symposium, we will discuss the molecular basis of DNA replication stress tolerance as well as the therapeutic strategy for cancer, focusing on the cause and response of DNA replication stress, implicated in molecular pathology.

State-of-art technology reveals therapy-resistant tumor microenvironment

organizer
Noriko Gotoh (Kanazawa University), Koji Okamoto (Teikyo University)

Detail

Cancer tissues are comprised with not only cancer cell population including cancer stem cells but also cancer associated fibroblasts, immune cells and other cell populations. All these cells construct enormously complex tumor microenvironment which confers therapy resistance. In this symposium, we would like to introduce researches aiming at elucidation of the tumor microenvironment by using state-of-art technologies: special transcriptome, single cell analysis, organoid cultures, and so on.

Genome biophysics: Biophysical approaches to understand the dynamics of nuclear biomolecules

organizer
Tsuyoshi Terakawa (Kyoto University), Tetsuya Yamamoto (Hokkaido University)

Detail

On genomic DNA, various biological phenomena such as DNA replication, transcription, and repair simultaneously take place and are regulated by the 3D genome structure. To understand the principles of genome structure formation and the correlation between structure and function, it is essential to have an interdisciplinary approach involving researchers from various fields, transcending the boundaries of experimental and theoretical frameworks and methods. Through this symposium, by featuring presentations by young researchers tackling this issue with a biophysical approach, we aim to bring a fresh perspective to molecular biology.

Frontiers of the structural basis of drug investigation targeting membrane proteins and multi-protein complexes

organizer
Tsuyoshi Imasaki (Kobe University), Masato Suzuki (National Institute of Infectious Diseases)

Detail

Drug discovery targets increasingly focus on "undruggable" molecules, such as membrane proteins and multi-protein complexes. Advances in technology and techniques, such as the integration of X-ray crystallography, NMR, cryo-electron microscopy, and AI, are enabling the exploration of molecular targets previously considered intractable for drug discovery. In this session, experts in the field, including young researchers, will present the latest research and multi-disciplinary approaches for drug discovery research utilizing structural biological knowledge of these challenging targets.

Various post-translational modifications on cellular dynamics

organizer
Mio Iwasaki (Kyoto University), Takeshi Kawamura (The University of Tokyo)

Detail

Proteins undergo more than several hundred types of post-translational modifications to alter their functions and regulate various biological phenomena. In this session, we will focus on post-translational modifications of proteins, and introduce research related to major modifications such as phosphorylation, glycosylation, and ubiquitination, as well as lipid and carboxylation. We will discuss the importance and future challenges of post-translational modification analysis.

Updated pathophysiology of glycation mediated by lipoxidation
Supported by: The Japanese Maillard Reaction Society, JMARS

organizer
Reiko Inagi (The University of Tokyo), Kiyotaka Nakagawa (Tohoku University)

Detail

Alteration of glucose/lipid metabolism is one of the causal factors of the development/progression of various diseases. It induces protein homeostatic derangement by glycation (unfavorable posttranslational protein modification) and oxidative stress mediated by lipoxidation. Glycation and lipoxidation contribute to each other: glycation (Maillard reaction) is progressed by not only the glucose-derived reactive carbonyl compounds but also lipid-derived products. In this session, we focus on lipoxidation-mediated glycation and its pathophysiology under glucose/lipid metabolic disease conditions.

Biology innovations by creative computing

organizer
Nozomu Yachie (The University of British Columbia), Wataru Iwasaki (The University of Tokyo)

Detail

With the blooming of molecular biology and genomics, bioinformatics and computational biology have emerged and rapidly developed over the last few decades. Computational approaches began to be incorporated to interpret extensive biological data, while strategic designs of biological experiments led by new computing visions for discovery have emerged only recently. At the same time, the biology community and scientists have become native to high-performance computers. Today, scientists of the next generations have been thriving impressively. In this symposium, we will have speakers with unlimited imaginations so we can face that our augmented capability with computers could surpass our current imaginations in biological science even more. The organizers aim to prime the next innovative science by the audience with inclusive and brave visions.

In vivo technologies to study neuron arbor differentiation

organizer
Adrian Moore (RIKEN), Takuji Iwasato (National Institute of Genetics)

Detail

Neurons differentiate and assemble into circuits through enormous structural rearrangements of dendrites, axons, and synaptic connections over developmental time. Dysregulation of this process leads to neurodevelopmental disorders. We focus on new imaging, machine learning-based image analyses, and molecular genetic approaches to study the dynamics and regulation of arbor differentiation in vivo.

Intranuclear event as therapeutic target of human diseases

organizer
Takashi Ito (Nagasaki University), Satoshi Inoue (Tokyo Metropolitan Institute of Gerontology)

Detail

Recent advances have revealed that intranuclear event including modification of chromatin structure is an important determinant of cell fate, function and Disease Development. Transcription factors such as ER, enzyme complexes that catalyze covalent modifications of histone tails, and ATP-dependent chromatin remodeling complexes contribute to changes in chromatin architectures, either enhancing or repressing gene expression. These intranuclear event has dedicated functions at developing human diseases by inappropriate gene expression and can be target of therapy. In this cession we focus intranuclear event as therapeutic target of human diseases.

Evolutionary perspectives of chromatin in the three domains of life
Co-hosted by: Large-Scale Genome Synthesis and Cell Programming, CREST and PRESTO, Japan Science and Technology Agency

organizer
Naomichi Takemata (Kyoto University), Akihisa Osakabe (The University of Tokyo)

Detail

Eukaryotic genomes organize their structures and functions by forming an intricate nucleoprotein complex called chromatin. It is poorly understood how the chromatin-based mechanism of genome organization emerged and diversified in the history of life. This symposium will bring together distinguished international researchers studying eukaryotes, bacteria, and archaea to discuss the evolution of chromatin structures and functions.

The biological mechanisms originating species-specific traits

organizer
Ikuo Suzuki (The University of Tokyo), Ryohei Iwata (VIB Center for Brain & Disease Research/KU Leuven)

Detail

Every species has unique characteristics that have helped it to adapt and survive during evolution. Recent technological advances allow us to investigate the evolutionary mechanism behind the emergence of species-specific traits. In this symposium, we will discuss the principles of the biological mechanism that gives rise to species uniqueness, based on the studies conducted by the invited speakers using different model species.

Functional non-coding RNAs in a variety of biological processes

organizer
Noriko Saitoh (The Cancer Institute of JFCR), Nobuyoshi Akimitsu (The University of Tokyo)

Detail

Numerous noncoding RNAs exist in eukaryotic cells. They are considered to be important regulators of life, because many of them are expressed in a cell type-, differentiation stage- and disease- specific manner. They may function through novel mechanisms including bio-molecular condensates. This symposium will provide opportunities to introduce and discuss cutting-edge researches on non-coding RNAs, including molecular mechanisms and functions, and potential as a therapeutic target for diseases.

New insights of molecular mechanism underlying life-style diseases related-carbohydrate signals

organizer
Kazuki Mochizuki (University of Yamanashi), Iwasaki Iwasaki (Kyoto Prefectural University)

Detail

Excessive carbohydrate intake induces onsets of life-style diseases including type 2 diabetes mellitus (T2DM), although the signal transduction was unclear. This symposium introduces new aspects of carbohydrate signals via taste, vagus nerve, epigenetics, circadian rhythm, and mechanism underlying development of life-style diseases by disorders of carbohydrate signals in model animals and T2DM patients.

Challenges for next-generation in vitro culture technology

organizer
Kazuaki Nakamura (National Research Institute for Child Health and Development), Nobuhiko Kojima (Yokohama City University)

Detail

Cell culture has contributed greatly to molecular biological research to date. On the other hand, it has been recognized that in vivo physiological functions cannot always be reproduced in petri dish culture. Tissue models that reproduce in vivo functions will dramatically improve our understanding of the molecular basis of cellular functions. This symposium will focus on new cell culture techniques as tools for advancing molecular biology, and will discuss the potential of cell culture and future challenges.

Unravelling the dynamics of life systems with high-depth omics

organizer
Teppei Shimamura (Tokyo Medical and Dental University), Tsuyoshi Osawa (The University of Tokyo)

Detail

Diseases such as cancer and lifestyle-related illnesses, as well as the progression of infections, are greatly influenced by various inter-hierarchical interactions at molecular, organellar, cellular and tissue levels, however, the exchange of life information between and within these hierarchies remains elusive. This symposium will bring together pioneering young researchers and introduce the research field of biosystem dynamics using cutting-edge omics, imaging analysis, and information analysis. Additionally, it will provide an opportunity for aspiring young researchers to enter the field.

Disease therapeutic strategy targeting epigenome alterations

organizer
Hideyuki Takeshima (Hoshi University), Hisanori Takenobu (Saitama Cancer Center)

Detail

Our body responds to various extracellular stimuli by operating the homeostatic maintenance system. However, enhanced or prolonged stimuli disrupt the maintenance mechanism, and such state can be memorized as alterations of epigenome. The accumulation of epigenome alterations leads to the onset of various diseases, such as cancers. In this symposium, we will focus on epigenome regulation and its alterations, and discuss the therapeutic strategy targeting such alterations and potential modality.

Spatiotemporal dynamics of vasculature development
Co-hosted by: Japanese Vascular Biology and Medicine Organization

organizer
Tetsuro Watabe (Tokyo Medical and Dental University), Utako Yokoyama (Tokyo Medical University)

Detail

The vasculature is the essential network to connect all organ systems to sustain life. The blood and lymphatic vessels sense and utilize dynamically fluctuating mechanical stress, and develop to acquire site-specific functions. To understand how the diverse vasculature components are spatiotemporally regulated, this symposium will focus on cutting-edge research topics in the field of vascular biology and medicine.

Understanding Higher Biological Phenomena Driven by Cell Digital Society

organizer
Seitaro Nomura (The University of Tokyo), Hiroyuki Aburatani (The University of Tokyo)

Detail

In life sciences, the diversification and advancement of data measurement and analysis are rapidly progressing. With the development of single-cell analysis, measurement technology, design engineering, and biophysics, it has become possible to capture the molecular behavior of cells in living organisms in an integrated and quantitative manner. We have come to be able to know how cells build society while communicating with surrounding cells, as if cells transmit digital information, deepening the understanding of the molecular mechanisms of higher biological phenomena such as disease, aging, and cancer. In this symposium, we aim to integrate and converge these diversified and advanced digital analysis technologies in a cross-disciplinary manner, and to build a new theory of life science centered on Cell Digital Society.

Comparative Biology aiming for the Application to Human Health

organizer
Tohru Ishitani (Osaka University), Kyoko Miura (Kumamoto University)

Detail

Innovation in omics and genome editing technologies has allowed for the analysis of all living organisms, helping us understand evolution and development through comparative biology. In this symposium, we will focus on futuristic comparative studies that aim to clarify the molecular basis of advanced biological functions such as regeneration, aging, cancer resistance, and hibernation, with the goal of applying these insights to improving human health.

Perivascular cell dead reckoning

organizer
Seiji Yamamoto (University of Toyama), Atsushi Enomoto (Nagoya University)

Detail

“Dead Reckoning" is an analytical navigation method based on the positional information from past and present, traveling distance, starting point, and drift correction angle. For the perivascular cell research, it has been conducted the dead reckoning research approach. It is because, there are lots of indeterminant factors including distance from endothelial cells, microenvironment, and identity of the perivascular cells. This symposium aims to provide an integrated understanding and in-depth discussion of the various findings regarding perivascular cells which is their origin, regulatory function in blood vessels, and the pathogenesis of intractable diseases.

Uncovering cardiac morphology and function through multifaceted approaches

organizer
Yusuke Watanabe (National Cerebral and Cardiovascular Center Research Institute), Maretoshi Hirai (Kansai Medical University)

Detail

The heart is composed of various cell types, including cardiomyocytes, and it plays a vital role in systemic circulation as a pump with a complex structure. This symposium will provide an opportunity to introduce and discuss the latest findings of "cardiac morphology and function" through multifaceted approaches using leading-edge imaging and NGS technologies to deepen our knowledge of the heart seamlessly from the sub-micron to the macroscopic level.

DNA repair and genome stability maintenance mechanisms decoded by chemical modifications

organizer
Syota Matsumoto (The University of Tokyo), Junpei Yamamoto (Osaka University)

Detail

Chemical modifications of DNA and proteins govern various biological events in life. While modifications in DNA, potentially leading to formation of DNA damage, consist of the negative aspects for the biological processes, organisms fine-tune chemical modifications in protein such as histone modifications to maintain the genome stability. In this symposium, we focus on the chemical aspects of DNA repair and genome stability maintenance mechanisms and discuss the latest outcomes.

3D nuclear architecture mediated by the transposable element code (TEC)

organizer
Jafar Sharif (RIKEN), EMI Hibino (Nagoya University)

Detail

Transposable elements (TEs) such as SINEs and LINEs occupy about half of the mammalian genomic DNA. Of note, SINEs and LINEs are enriched in mutually different compartments in the genome. Recent studies show that SINEs recruit the 3D genome regulatory protein CTCF, while LINE L1 RNA also plays a role to mediate heterochromatin organization via phase separation. In this symposium, we propose that the transposable element code (TEC) mediated by SINEs and LINEs may regulate 3D nuclear architecture, and invite research topics broadly related to transposable elements and 3D genome architecture.

A new era of Wnt signaling research

organizer
Koji Kikuchi (Kumamoto University), Yusuke Mii (National Institute for Basic Biology)

Detail

Wnt signaling plays important roles in tissue morphogenesis and homeostasis, and its abnormalities are deeply related to diseases including congenital disorders and cancer. 40 years have passed since the discovery of Wnt, and the research field of Wnt signaling has greatly expanded, but with the advent of new analysis techniques and innovative multidisciplinary approaches, a new trend is emerging in Wnt signaling research. In this symposium, we would like to discuss a new era of Wnt signaling research.

Mechanisms of homeostatic behaviors across animals and species

organizer
Hiromasa Funato (Toho University), Azusa Kamikouchi (Nagoya University)

Detail

Sleep, courtship, parental behavior, aggression, and feeding are vital for the survival of animals, either as an individual or as a species. These behaviors are regulated by a mixture of conserved and diversified mechanisms between animal species, at both the molecular and neural circuit levels. This symposium provides an overview of the mechanisms that animals have evolved to maintain the "homeostasis of the individual and the species" by delving into the diversity and similarity of mechanisms underlying it.

Specialized brain functions tuned by glial cell diversity

organizer
Yuki Hattori (Nagoya University), Jun Nagai (RIKEN)

Detail

Maintaining brain homeostasis, glial cells have long been thought to be a homogeneous population of cells. Meanwhile, recent advances in single-cell transcriptomic analysis and molecular profiling have revealed their diversity. However, when, where, and how glial cell diversity emerges and contributes to specialized brain functions remain unclear. In this symposium, the speakers will introduce their cutting-edge researches about the spatiotemporal characteristics of glia across the lifespan. Through the knowledge sharing of unique techniques, we will further discuss newer approaches to elucidate the mechanisms that facilitate brain development and function.

Right time, right scale: cell division regulation

organizer
Midori Ohta (Okinawa Institute of Science and Technology), Yasutaka Kakui (Waseda university)

Detail

Accurate cell division requires timely changes in dimensions and numbersof cellular components, such as chromatin, centrosomes, and spindlemicrotubules. New technologies provide an opportunity to understand thecomplex mechanisms coordinating size and time during mitosis. In thissymposium, we focus on “scaling" mechanisms of mitosis that ensuresfaithful cell division and share the latest findings from diverse experts.

Fibroblast Biology: Unraveling the Functions of Connective Tissue Cells

organizer
Takashi Nishina (Toho University), Yosuke Kurashima (Chiba University)

Detail

Recent studies have revealed that fibroblasts, a key component of connective tissue, play crucial roles in maintaining tissue homeostasis, as well as inflammatory diseases, and cancer development. In this symposium, we will discuss the recent findings by researchers from Japan and abroad on how fibroblast activation and function are elegantly regulated.

Frontiers in pluripotent stem cell biology

organizer
Masaki Kinoshita (University of Nottingham), Toshihiro Kobayashi (The University of Tokyo)

Detail

It has been more than 40 years since first mouse embryonic stem cell lines were reported. Since then, we have successfully captured such early embryonic pluripotent cells from various timepoints and from different species including humans. In this symposium, we want to discuss the recent understanding of mammalian pluripoteny in culture and their differentiation potential including extraembryonic and germline lineage.

Spatiotemporal multiscale analysis for metabolism
Co-hosted by: Japan Science and Technology Agency

organizer
Natsuki Osaka (Tokyo Institute of Technology), Toshiya Senda (High Energy Accelerator Research Organization)

Detail

Multiscale analysis, which is essential for the analysis of cellularfunctions, requires the integration of multiple methods over a widespatio-temporal range. In this symposium, we will present the progress ofour GTP energy metabolism research as an attempt at multiscale analysis. Inaddition, we will discuss wanted technologies for multiscale analysis andfuture metabolic research.

Renaissance Nutrition: Fundamentals & Applications

organizer
Shin-Ichiro Takahashi (The University of Tokyo), Takafumi Miyamoto (University of Tsukuba)

Detail

To maintain and improve our health through diet, we must understand "what, when, and how much" we should eat. Nutritional science, which began in the late 18th century, has yet to provide a clear answer to this question. In this symposium, we will present a wide range of basic and applied nutrition research to understand the importance of nutrients in inducing specific phenotypes, and discuss how nutrition research should be developed for the next generation.

Cutting edge of BioID technology: Protein-protein interaction analysis from cell to in vivo organism
Sponsored by: PROS Joint Research Program for Protein Interactome (PRiME)

organizer
Hirotaka Takahashi (Ehime University), Ichiro Taniuchi (RIKEN)

Detail

Many proteins function by forming complex with other proteins in the living organisms. To elucidate the functions of proteins of interest and how they are regulated, it is essential to identify partner proteins in the complex in an unbiased manner. In this symposium, we will focus on proximity-dependent biotin labeling (BioID), a powerful tool for the protein interactome analysis, and will introduce the recent successful applications of the BioID technologies from cells to in vivo organisms levels, and will discuss future applications of this technology.

Long noncoding RNA and cellular program of gene regulation -Molecular Biology of lncRNA and its binding protein-

organizer
Riki Kurokawa (Saitama Medical University), Masato Katahira (Kyoto University)

Detail

In 21st century, it has been shown that many RNAs away from the Central Dogma are transcribed from the genome. Most of these RNAs are the functional lncRNAs working upon their binding to proteins (RBPs). Given disorder in RBPs, they would induce neurodegenerative diseases and also cancers, although most of their functions and related mechanisms remain elusive. We organize a symposium with experts for divergent lncRNAs and are expected to get a novel trend there.

Common system of post-Golgi traffic in the eukaryotic cell

organizer
Tomohiro Uemura (Ochanomizu University), Akiko K Satoh (Hiroshima University )

Detail

A variety of proteins synthesized in the eukaryotic cell are transported to the final destinations where they function. Membrane traffic is one of the key systems among several transport systems to maintain cellular homeostasis. In this symposium, we will explore the "common system of post-Golgi transport in the eukaryotic cell " through presentations on post-Golgi trafficking in diverse species such as animals, yeast, and plants.

Modification Biology - Elaborate control systems of biological sciences via molecular modification-

organizer
Masamitsu Konno (Advanced Industrial Science and Technology), Keisuke Hitachi (Fujita Health University)

Detail

Molecular modifications are increasing attention as systems that control various biological phenomena. In this symposium, we will discuss with young scientists who have discovered cutting-edge findings on the biological control systems produced by molecular modifications, especially methylation on RNA and protein. Through this, we will present the current status and prospects of the research field of molecular modification.

Robotic Biology and Laboratory Automation for Molecular Biology

organizer
Genki Kanda (RIKEN), Haruka Ozaki (University of Tsukuba)

Detail

The automation of research, including experimental manipulation, through robotics and information technology has the potential to liberate and expand molecular biology from the constraints of manual experimentation. This new research trend, "robotic biology", enables us to approach new molecular biological problems across the boundaries of basic to clinical, model to non-model organisms, and wet to dry. In this symposium, a new generation of researchers promoting robotic biology will discuss its potential by presenting real examples. (*Tour of the robotic facility will be held at the building near the venue after the symposium.)

Microscopic and macroscopic world created by endoplasmic reticulum

organizer
Satoshi Ninagawa (Kobe University), Yuko Arioka (Nagoya University Hospital)

Detail

One of the primary roles of the endoplasmic reticulum (ER) is to perform protein biosynthesis of approximately one-third of all proteins and to regulate their quality. Therefore, the close link between molecules in the ER and human disease has been elucidated. With recent improvements in analytical techniques, this is now beginning to be understood at an accelerated pace. In this symposium, young researchers from Japan and abroad who are working at the forefront will gather and discuss the multiscale world created by the ER from a microscopic perspective focusing on the elucidation of functions of ER molecules and a macroscopic perspective regarding diseases.

New trends in“post-Cas9"genome editing
Co-hosted by: The Japanese Society for Genome Editing

organizer
Kazuto Yoshimi (The University of Tokyo), Tetsushi Sakuma (Hiroshima University)

Detail

After the generalization of genome editing technologies, the editing toolbox continues to expand for manipulating cellular and organism functions safely, precisely, and freely. These “post-Cas9" tools have developed by finding new CRISPR immune systems or fusing various enzymes with dCas9. In this session, we focus on the research of these new technologies and discuss the new trends in genome editing.

Nuclear dynamics in the nervous system

organizer
Fuminori Tsuruta (University of Tsukuba), Yusuke Kishi (The University of Tokyo)

Detail

During the process of development, aging, and disease, the nuclear morphology and structure continuously change in the brain. These dynamic changes have an impact on gene expression through epigenetic and chromatin regulation. Also, they are involved in cell-autonomous signaling and intercellular communication. In this symposium, we will introduce recent findings on nuclear dynamics in the brain under physiological and pathological conditions.

Academic Drug Development Conference 2023

organizer
Yoshiki Ikeda (Kyoto University), Saeko Yanaka (Kyushu University)

Detail

With the depletion of drug target molecules these days, there is growing interest in the unique seeds and drug discovery methods of academia. In order to greatly develop drug discovery in academia, it is important to know the "Right now" of drug discovery and to build a system for active mutual technical collaboration. Therefore, at this meeting, we will invite up-and-coming speakers who promote academic drug discovery, and we will focus on the development of drugs using the latest antibodies and peptides and research that applies them. Through these latest technologies and research contents, we will strive to establish a mutual support network in academic drug discovery.

Chromosome End Drama: What Will Telomeres Do?

organizer
Makoto Hayashi (Kyoto University), Junko Kanoh (The University of Tokyo)

Detail

Telomeres, which protect the ends of eukaryotic chromosomes, play a crucial role in the survival of unicellular organisms and the maintenance of stem cell function and organization in multicellular organisms. They are also used by cancer cells to achieve immortality. This symposium will cover recent advances and future developments in telomere biology and its relationship to biological homeostasis, disease, and cancer treatment strategies. By accepting multiple abstracts, we aim to foster new collaborations within and outside the field and create a welcoming environment for new and young researchers in this dynamic field.

Dynamics of cell state transitions in cardiovascular system

organizer
Tomohisa Sakaue (Ehime University), Hiroyasu Kidoya (Fukui University)

Detail

The vascular system is organized by the terminal differentiation of lateral plate mesoderm-derived hemangioblasts. Recent cutting-edge technologies such as single cell analysis and bio-imaging unveiled that the differentiated cells can be transformed into cells with newly functions by re-writing genomic status, thereby contributing to the pathogenesis of cardiovascular diseases. In this symposium, we will introduce the dynamics of cell transitions in the vascular system unveiled utilizing the latest technologies and discuss their role in pathogenesis.

Construction and manipulation of biological phenomena by molecular network design

organizer
Daisuke Kiga (Waseda University), Mariko Okada (Osaka University)

Detail

The rise of Systems Biology and Synthetic Biology is rooted in the amassment of biological data. Thus, these disciplines are regarded as a fast-track to the bio-digital transformation and the creation of digital twins. At this symposium, we aim to present the cutting-edge advancements in molecular and network design utilizing biological data, with a focus on comprehending and manipulating biological phenomena. Additionally, we seek to foster a more in-depth discourse on the prospects of life sciences research beyond bio-DX.

Upfront Molecular Biology of RNA-Nucleoprotein Complexes from Asia

organizer
Akila Mayeda (Fujita Health University), Woan-Yuh Tarn (Academia Sinica)

Detail

We focus on newly discovered functions of ribonucleoprotein particles (RNPs), or RNA-nucleoprotein complexes. These RNPs possess a variety of molecular activities for important biological and physiological functions. From Asian countries, we invited young and/or women scientists who are getting exciting unpublished results with innovative approaches in this filed. Importantly, all these basic studies have promising potential for therapeutics development in diseases and cancer.

Cell interfacial environments dictating biological functions
Co-hosted by: Grant-in-Aid for Transformative Research Areas (B) Pressio neuro-brain science

organizer
Hiroaki Hirata (Kanazawa Institute of Technology), Masatoshi Morimatsu (Okayama University)

Detail

Information exchange via chemical and physical interactions at membranous interfaces of cells is essential for regulation of tissue/organ functions, wherein modulation of mechano-chemical properties of membranes is involved. Especially, studies in recent years have unveiled that mechanical inputs through the membranous interfaces cause a wide range of cellular responses, bringing a new dimension in the research of development and functions of tissues. In this symposium, we share and discuss cutting-edge studies on how interfacial environments of cells contribute to physiological and pathological functions from molecular system to tissue levels.

Cellular protrusions and their new roles and mechanisms of formation

organizer
Shiro Suetsugu (Nara Institute of Science and Technology), Tetsuya Takeda (Okayama University)

Detail

Cells have various protrusion structures. Filopodia are involved in cell movement and cell-cell adhesion. Microvilli are localized on the apical surface of cells. Invadopodia and podosomes are involved in cell invasion. Retraction fibers are left on the trailing edge of the cells. These protruding structures are dynamic, and previously unrecognized shedding of these protrusions was reported recently. We will discuss the construction of these structures by proteins to elucidate new functions.

Beyond the structure: new aspects of RNA/Protein without defined structure and the origin

organizer
Satoru Ide (National Institute of Genetics), Hanae Sato (Kanazawa University)

Detail

Biopolymers such as RNA and protein are folded into the 3D structure and interact with specific factors to perform the functions. However it is becoming evident that biopolymers without defined structures also play crucial roles in various biological phenomena such as liquid–liquid phase separation. It is challenging to understand their fundamental characteristic without conserved motifs or domains using a molecular prediction approach. How did they emerge and evolve in cells? Here we highlight the recent studies about structureless biopolymers and discuss their functions and origins during evolution.

Gut-Design based on understanding causality between commensal microbiota and disease

organizer
Nobuo Sasaki (Gunma University), Shinji Fukuda (Keio University)

Detail

As Fecal Microbiota Transplantation was approved a national advanced medical treatment B for the Ulcerative Colitis patient in 2023, the recent gut-microbiota field has moved into its next phase. Remarkably, it becomes trend that proof of causality their relationship, and entering a new era of “manipulating" the microbiome. In this symposium, we will introduce the state-of-art of research on the intestinal ecosystem and discuss how to design our gut environment.

Comprehensive Approach to Organelle Dynamics from Lipids

organizer
Hiderou Yoshida (The University of Hyogo), Kentaro Hanada (National Institute of Infectious Diseases)

Detail

Although organelles have been thought to be independently functional units, recent studies have revealed that functional zones exist in organelles and that organelle functions are dynamically controlled by various interactions between different organelle zones, such as lipid transport. In this symposium, we will focus on the lipids that constitute the organelle zones and discuss the latest research findings on the regulation of organelle zones by lipids.

Seeing, elucidating, and controlling biomolecules in the cell using physical methods

organizer
Akira Kitamura (Hokkaido University), Takehito Tanzawa (Osaka University)

Detail

A large number of biomolecules, such as nucleic acids, proteins, and lipids, exist inside and outside of cells to physiologically maintain them "alive". The visualization and analysis of the activities of these biomolecules using physical methods to elucidate and control their functions is an indispensable theme in current and future molecular biology. Here, we review and discuss the pioneering research topics mainly in fluorescence imaging, fluorescence spectroscopy, electron microscopy, and so on.

Understanding the kinetics for brain dysfunction and neurodegenerative disorders
Co-hosted by: Grant-in-Aid for Transformative Research Areas B "Kinetics-Driven Supramolecular Chemistry"

organizer
Masaki Okumura (Tohoku University), Tomohide Saio (Tokushima University)

Detail

Kinetic control is observed in many biological systems. For example, protein folding is intrinsically error-prone, and random coil polypeptides must be navigated under the kinetic control to undergo folding into native structure without aggregation. In this symposium, we will discuss the latest findings with the brain dysfunction and neurogenerative disorders from a multidisciplinary perspective.

Molecular mechanisms governing fetal-maternal crosstalk

organizer
Kenichi Miharada (Kumamoto University), Joji Kusuyama (Tokyo Medical and Dental University)

Detail

Maternal environment plays pivotal roles during pregnancy, potentially affecting individuals' lives even after birth. However, many of those regulations are still in a black box. It is imperative to uncover the molecular basis behind the fetal-maternal interaction to understand the principles of recurrent pregnancy loss (fetal growth retardation) and DOHaD. In this symposium, we share the latest findings from relatively junior researchers to unveil the molecular mechanisms of fetal-maternal interaction.

Mechanisms of avoiding sex extinction approaching from a variety of sex chromosomes
Co-hosted by: Grant-in-Aid for Transformative Research Areas (B) Sex chromosome cycle

organizer
Takuya Abe (Tokyo Metropolitan University), Yusuke Kazama (Fukui Prefectural University)

Detail

In Y and W chromosomes, genetic information is lost at a faster rate than in autosomes. Since the disappearance of sex chromosomes leads to the extinction of a species, how to overcome this crisis is a common subject for all organisms with sex chromosomes. In this symposium, researchers working with various unique organisms will introduce the hidden function and the mechanism of inheritance of sex chromosomes. With these topics, we will discuss the mechanism by which organisms can avoid the loss of sex.

Adaptive mechanisms mediated by biomolecular condensates under stress conditions

organizer
Akira Nakai (Yamaguchi University), Mutsuhiro Takekawa (The University of Tokyo)

Detail

Biomolecular condensates are membraneless compartments that concentrate biomolecules including proteins and nucleic acids, and play roles in various cellular processes, such as transcription, translation, and degradation. The condensates transiently formed under stress conditions, such as high temperature and high osmotic stresses, play important roles in maintenance of cellular homeostasis through regulation of specific biological processes. In this symposium, we introduce the regulatory mechanisms and functions of the nuclear stress bodies, cytoplasmic stress granules, proteasome droplets in the nucleus, and previously unknown condensates. Based on these observations, we will discuss to comprehensively understand adaptive mechanisms mediated by biomolecular condensates.

Developmental adaptation to environment in multicellular organisms

organizer
Naoki Okamoto (University of Tsukuba), Fumiaki Obata (RIKEN)

Detail

Developmental processes in multicellular organisms are robust biological processes that are genetically programmed yet flexibly and appropriately regulated in response to various environmental conditions. In this symposium, researchers using a variety of model organisms, including plants, invertebrates, and vertebrates, will come together to share their latest findings on the diverse environmental responses during development, aiming for an integrated understanding of the environmental response strategies that ensure developmental processes in multicellular organisms.

Opening up next generation of neuropsychiatric disease research through “creative biology"

organizer
Hideya Sakaguchi (RIKEN), Yuko Arioka (NAGOYA University)

Detail

The differentiation technology of neural cells/tissues from human pluripotent stem cells (which is a part of “creative biology") have made it possible to bring living neural materials which contribute to study the mechanisms of several neuropsychiatric diseases. In this symposium, we will overview the history of neural induction technology, introduce the front line of this research field, and lastly discuss the future perspectives of “creative biology" to study neuropsychiatric diseases.

Multi-biological phenomena tell the importance of glycosylation ~from the development to diseases~

organizer
Haruhiko Fujihira (RIKEN), Kentaro Kato (Nagasaki University)

Detail

Glycosylation is a post-translational modification and is involved in various biological phenomena (protein/lipid function, viral/parasitic infection, immune response) and defects in glycosylation cause many diseases. In this symposium, the importance of glycosylation revealed by biological/chemical studies to understand such glyco-related phenomena/diseases will be introduced by up-and-coming researchers.

Gene functions and its regulations enabling the environmental exploitation

organizer
Hiroyasu Kamei (Kanazawa University), So Masaki (Ritsumeikan University)

Detail

Cells and organisms maintain homeostasis via molecular mechanisms that counteract adverse factors arise in environmental fluctuations. On the other hand, life sometimes exploits extreme environments or adverse factors to induce beneficial functions in a context-dependent manner for survival. This symposium will focus on the various molecular mechanisms that enable such environmental exploitation.

Frontiers in Polyamine Research

organizer
Tomoyoshi Soga (Keio University), Masahiro Sugimoto (Tokyo Medical University)

Detail

Polyamines are positively charged and bind to DNA and RNA and are involved in various biological processes. In cancer, abnormalities in polyamine metabolism are frequently observed, indicating that elevated polyamine levels are required for transformation and tumor progression, making polyamines not only a target for anticancer drugs but also a diagnostic agent. Furthermore, recent studies have revealed that polyamine directly affects T cell function. In this symposium, we will discuss the latest polyamine research.

Deciphering inter-organ communications from immune cell behavior

organizer
Tomoko Yamakawa (National Institute of Technology （KOSEN）, Ibaraki CollegeNational Institute of Technology （KOSEN）, Ibaraki College), Masato Enomoto (Kyoto University)

Detail

Immune cells are known to be important for biological defense against pathogenic microbes. Recent studies have revealed that immune cells spatiotemporally control multiple phenomena such as animal development, tissue homeostasis, cancer and neurodegeneration. In this symposium, we will focus on immune cell behavior in various biological responses and will discuss interorgan communications in multicellular systems.

Various forms of phagocytosis: A Novel Insight into Evolution and Cell Diversity

organizer
Sho Morioka (Gifu University), Kumiko Tsukui (National Institute of Infectious Diseases)

Detail

Recent studies have unveiled an intriguing form of cell-cell communication through various types of phagocytosis, including the lesser-known phenomenon of cell nibbling, or trogocytosis. This unique communication method involves cells "exchanging information" by nibbling on or engulfing neighboring cells, which stands in contrast to the traditional ligand-receptor mediated signal transduction.In this engaging session, we will delve into how this special form of cell-cell interaction has led to the establishment of diverse functions in phagocytic cells, moving beyond mere transient reactions to environmental stimuli. The fascinating scope of our discussion will encompass the different manifestations of phagocytosis in bacteria, immune cells, and their connections to various disease pathologies.Join us as we unveil the previously unrecognized significance of phagocytosis in fostering evolution and promoting cellular diversity, shedding light on a groundbreaking aspect of cell-cell communication.

mRNA translation governs organisms and diseases

organizer
Masahiro Morita (University of Texas Health Science Center at San Antonio), Ola Larsson (Karolinska Institute)

Detail

mRNA translation has been considered to be one of the central and fundamental processes in the cell. New technologies have re-defined our dogmatic notion of mRNA translation and re-clarified the basic mechanisms and regulation of mRNA translation that impact on a large range of biological mechanisms and diseases. Recent remarkable discoveries have revealed global control of protein synthesis and selective translation of specific mRNAs are crucial for the development of diseases, such as cancer and neurological disorders. In this symposium, we will introduce a perspective of current and future research of molecular mechanisms and physiological functions of mRNA translation.

Tissue development and maintenance by dynamic extracellular matrices

organizer
Mikiko Inaki (Osaka University), Yutaka Matsubayashi (Bournemouth University)

Detail

Tissues consist of cells and extracellular matrices (ECMs). While ECMs have often been thought of as static scaffolds of cells, recently it is being revealed that ECMs are in fact rapidly moving and replacing components. These ECM dynamics are suggested to generate forces to remodel tissues. In this symposium, we discuss how ECM dynamics in diverse organisms ranging from C. elegans to mammals contribute to tissue morphogenesis and homeostasis.

Multi-layer regulation of chromosome dynamics, maintenance and functions

organizer
Hisao Masai (Tokyo Metropolitan Institute of Medical Science), Asako Sakaue-Sawano (RIKEN)

Detail

Chromosomes are regulated at multiple levels including primary and higher-order structures of nucleic acids, epigenome and foldings/ nuclear locations of chromosomes. Each process is regulated by complex interactions between DNA-RNA, protein-nucleic acids, and protein-nuclear membrane as well as by LLPS. Striking progress is being made to visualize regulation of cell cycle, replication, repair, transcription and epigenome as well as to clarify the functions and molecular dynamics of factors involved. In the symposium we want to discuss the multi-layer regulation of chromosomes by integrating findings made at individual levels.

New Perspectives on Mitochondria Research-from Single Molecule Dynamics to Multicellular Interactions-

organizer
Yuhei Araiso (Kanazawa University), Isshin Shiiba (Gakushuin University)

Detail

Mitochondria are essential organelles that act as centers of energy production and metabolism. In recent years, mitochondrial research has made remarkable progress as their novel functions have been revealed one after another. Here, we introduce the latest findings about mitochondrial biology mainly by young researchers. From single molecule analysis to physiological function research, we integrate micro, meso, and macro studies to discover new aspects of mitochondria.

The next generation of zinc signaling study

organizer
Toshiyuki Fukada (Tokushima Bunri University ), Taiho Kambe (Kyoto University)

Detail

Zinc plays fundamental roles to control expression, activation, cellular localization, etc., of various proteins. Zinc ion released from zinc transporters and channels acts as a signaling factor called zinc signal that participates in many physiological conditions. In this symposium, we will discuss recent advances and future goals of zinc signaling study with young researchers in zinc signaling field toward understanding its biological relevance in the molecular basis.

Genome science of aquatic animals reveals the evolution of vertebrates

organizer
Yoshihiro Omori (Nagahama Institute of Bioscience and Technology), Yukiko Ogino (Kyushu University)

Detail

Aquatic animals such as fish and amphibians have undergone unique evolution among vertebrates, and it is possible to study the mechanisms of morphogenesis and regeneration that is difficult to be analyzed using general mammalian models. In this session, researchers who aim to elucidate the molecular mechanisms behind the dynamic evolution of aquatic animals using the tools of genome science, which have made remarkable progress in recent years. We would like to discuss new strategies of researches of vertebrate evolution.

Epigenetic regulatory mechanisms in stem cell biology

organizer
Hirotsugu Ishizu (Keio University), Akihiko Sakashita (Keio University)

Detail

The zygote formed by fertilization is totipotent, capable of differentiating into all cell types and developing into an individual. However, the mechanism of how a fertilized egg attains totipotency remains enigmatic. Recent advancements in the study of early embryonic development and stem cell reprogramming have revealed dynamic alterations in the genomic architecture that initiate and reorganize epigenetic information. It is becoming clear that regulation of the epigenome through the activation of endogenous retroviruses plays a role in the programmed transition from totipotency to pluripotency during preimplantation development. In this symposium, we will present the most recent insights on the regulatory mechanisms of the epigenomes defining the characteristics of totipotent stem cells and explore the challenges in uncovering the epigenomic regulatory network underlying totipotency acquisition.

Toward translational research of neurodegenerative disease

organizer
Yuzuru Imai (Juntendo University), Genta Ito (Teikyo University)

Detail

While the population affected by age-dependent neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease is expected to continue to increase, overcoming these diseases is still a challenge. For Alzheimer's disease, antibodies against amyloid-β have been approved as disease-modifying therapy. For Parkinson's disease, a phase III trial has begun for an LRRK2 inhibitor. The development of these drugs was achieved by bridging basic and clinical research. However, there are few opportunities for basic and clinical researchers to meet together, which is an obstacle to bridging the gap between the two fields. This symposium is intended to provide an opportunity to build a research network by inviting up-and-coming basic and clinical researchers in their respective fields.

Emerging trends in cardiovascular biology

organizer
Ichiro Manabe (Chiba University), Yuichi Oike (Kumamoto University)

Detail

Cardiovascular research has moved far beyond traditional studies of cardiomyocyte contraction/hypertrophy and angiogenesis to analysis of the diverse cellular communities that make up the cardiovascular system and the close crosstalk with metabolism, immunity, endocrine, and nervous systems. For example, it is becoming clear that dynamic changes in cellular metabolism and communication between cardiovascular cells and fibroblasts, immune cells and neurons are essential for cardiovascular development, maturation and homeostasis. We would like to introduce these new trends in cardiovascular biology to researchers from diverse fields and discuss further developments.

A New Perspective in the Molecular Disease Pathophysiology of “Life-Aging-Disease-Death"

organizer
Tomoaki Tanaka (Chiba University), Tohru Minamino (Juntendo University)

Detail

The development of single-cell and spatial transcriptomics analysis and inter-organ/cellular single-cell network analysis techniques, coupled with the advancement of proteomics and data science, are opening up new perspectives on the pathogenesis of “life-aging-disease-death". In addition, biochemical methods such as liquid-liquid phase separation and the APEX2 system are being used to systematically capture nuclear events as well as mitochondrial metabolic signals - nutritional and metabolic signals - in order to elucidate pathological mechanisms and their underlying regulatory systems. In this symposium, we will introduce the pioneering researchers that have opened up the new molecular biology of "life-aging-disease-death" and deepen our discussion on future developments and possibilities.

The cutting-edge of whole-tissue and whole-organ analysis

organizer
Katsuhiko Matsumoto (The University of Tokyo, RIKEN)

Detail

The symposium aims to discuss the latest research in organ- and body-scale single-cell analysis, as the need for these techniques in biomedical research has been increasing. With technological breakthroughs making measurement and analysis possible, invited researchers will present and discuss advanced labeling, measurement, and analysis techniques. The symposium will provide a platform for the exchange of ideas and the sharing of cutting-edge technology in this rapidly growing field.

A new frontier of RNA biology

organizer
Naoyuki Kataoka (The University of Tokyo), Ken-ichi Fujita (Fujita Health University)

Detail

In eukaryotes, RNAs transcribed from genomic DNAs are subjected to many regulatory processes, including splicing. Recently, many works have been reported the pivotal roles of RNAs in gene expressions and wide spectrums of physiological processes. In this symposium, we would like to introduce cutting-edge topics including basic RNA biology, physiological Roles of RNAs and therapeutic approaches for diseases, to discuss the future development of a novel RNA biology by interdisciplinary merging with other biology fields.

Recent advances in structural biology

organizer
Hideaki Kato (The University of Tokyo), Hiroshi Nishimasu (The University of Tokyo)

Detail

Several innovations in cryo-electron microscopy have enabled us to understand our physiology at the atomic level. In this symposium, we would like to present and discuss the latest research topics ranging from conventional and time-resolved single-particle analysis of proteins and protein-nucleic acid complexes to cryo-electron tomographic analysis of cells.

Gametometabolism: Nutritional and metabolic control of germ cell formation and differentiation

organizer
Yohei Hayashi (Tohoku university), So Maezawa (Tokyo University of Science)

Detail

Germline emerges as primordial germ cells during embryogenesis and is maintained for a long period of time to maintain the reproductive function. The nutritional condition derived from mother during embryogenesis and neonatal development, and from the surrounding environment during adulthood, influences the metabolic state of germ cells and supporting cells, and is Involved in the control of epigenomic state and reproductive function. However, the research to elucidate such mechanisms is only just beginning. In this project, we will discuss the progress and perspectives of this field of research, which we define as “gametometabolism".

Flow patterning of molecular signaling towards understanding of the plant life system

organizer
Yoshihisa Oda (Nagoya University), Takumi Higaki (Kumamoto University)

Detail

Plants have evolved cellular systems that generate flow force and act as micro flow channels, instead of the cardiovascular system and cell migration ability. These cells coordinate to establish the trans-scale flow patterns that enable plants to supply substrates throughout the plant body and into discrete tissues. In this symposium, we discuss the mechanisms that underpin the plant-unique flow systems.

RNA-mediated Virus-Host interaction

organizer
Tomoko Takahashi (Saitama University), Masayuki Horie (Osaka Metropolitan University)

Detail

While viruses replicate using multiple factors such as host factors, cells interact with various viral factors to inhibit viral replication. Recently, unprecedented modes of interaction between viruses and host cells via RNA have been reported and these novel findings will contribute to the identification or development of the regulatory system of virus-host interaction. This symposium focuses on RNA-mediated virus-host interaction and aims to understand viral infection from the point of virology, immunology, and biology.

Back to the future: Microbiology Renaissance

organizer
Masakazu Kataoka (Shinshu University), Saori Kosono (The University of Tokyo)

Detail

With the rapid development of measurement and analysis technologies and computational power, we are now in an era of big data accumulation in various fields of life science. We would like to use this large metadata to answer philosophical questions such as understanding the life and the state of living organisms. And to apply these mechanisms to biotechnology, we would like to use microorganisms that are industrially applied in fermentation as for discussion. We will open a new and multifaceted field of microbiology using various methods such as information science, evolutional genetics, molecular biology, and fermentation science, and provide a continuum of topics.

Cutting-edge chemical biology technologies to "see, examine, and manipulate" living organisms

organizer
Shigehiro Kawashima (The University of Tokyo), Gosuke Hayashi (Naoya University)

Detail

Considering that biological phenomena in living organisms are expressed by chemical reaction networks among biomolecules such as nucleic acids and proteins, the living organism may be regarded as a large test tube for chemists. In this symposium, we will invite rising-star chemical biology researchers to introduce cutting-edge technologies for "seeing, investigating, and manipulating" living organisms. We hope that many audience members interested in the interdisciplinary field of chemistry and biology will attend the symposium and stimulate active discussion.

Chromosome, chromatin, and nuclear dynamics in sexual reproduction

organizer
Kei-ichiro Ishiguro (Kumamoto University), Satoshi Namekawa (University of California, Davis )

Detail

Sexual reproduction accompanies specific changes in chromosome, chromatin, and nuclear dynamics over broad range of species. In this symposium, we will discuss chromosome/chromatin/nuclear dynamics from different aspects of sexual reproduction, such as germ cell differentiation, meiosis, sex determination, and fertilization.

Decoding the Universality of Cell Growth Principles in Microorganisms

organizer
Nobuaki Kono (Keio University), Shogo Ozaki (Kyushu University)

Detail

At first glance, the process of bacterial cell growth may appear to be a simple system. However, a closer look reveals it to be a complex system where reactions are meticulously orchestrated to guarantee accurate DNA and protein synthesis, control cell size, and steady replication and division. This symposium will bring together international researchers who are challenging the intricacies of microorganism cell growth from various scientific perspectives, including biology, chemistry, physics, and theoretical modeling.

Understanding diversity and plasticity of organisms using emerging model systems

organizer
Yuichiro Nakajima (The University of Tokyo), Satoshi Naramoto (Hokkaido University)

Detail

Recent advancement in genome editing and the reduction in cost of genome sequencing have made it possible to conduct research at molecular level in a wide range of species. To address problems that are difficult to approach using conventional model organisms, it is crucial to select models with unique biological features and develop methods to reveal the mechanisms. This symposium will present the latest studies that utilize emerging model organisms of plants and animals, aiming to understand the mechanisms that generate morphological and life-cycle diversity as well as plastic natures of biological phenomena such as sociality, dormancy and regeneration.

Approaching "new dynamics" of collagen that creates tissue construction

organizer
Junpei Kuroda (Osaka University), Akira Satou (Okayama University)

Detail

Collagen molecules create higher order structures such as linear bundles and meshwork to create optimal physical strength, flexibility, and durability for each tissue. It is speculated that cells “assemble" collagen molecules, but this mechanism is largely unknown. This is because the collagen in the tissue is "invisible". In this symposium, we will discuss new aspects of collagen that create organization building by clarifying the real dynamics of collagen.

Is there any common principle of swarm intelligence?
Supported by: Grant-in-aid for Transformative Research Areas B: "Heterogeneous Swarm Intelligence"

organizer
Takeshi Kano (Tohoku University), Daiki Umetsu (Osaka University)

Detail

“Swarms" of living organisms behave intelligently as if the entire group were a single individual with a will. This behavior is generated by local interactions among the components of the swarm and is referred to as “swarm intelligence."Although the concept of swarm intelligence has been proposed several decades ago, each system has been treated separately; thus, the systematic design principle of swarm intelligence has not yet been established. To address issue, we focus on various swarming behaviors that range from cellular to individual scales and to discuss common principle by combining high-precision real data analysis and a synthetic approach using mathematical models and robots.

Exploring new horizons in understanding non-apoptotic cell death and its role in biological responses

organizer
Fuminori Tokunaga (Osaka Metropolitan University), Hiroyasu Nakano (Toho University)

Detail

Cell death plays a crucial role in various biological responses such as development, aging, and immune response and is also involved in disease onset. Recently, novel types of regulated cell death pathways such as necroptosis, pyroptosis, and parthanatos have gained attention. In this symposium, we will introduce and discuss the latest findings on these pathways, including inflammation, cancer resistance, senescence, and ubiquitination-mediated regulation.

Developmental regulation by dynamic repressive chromatin

organizer
Hiroki Sugishita (The University of Tokyo), Azusa Inoue (RIKEN)

Detail

Development involves sophisticated gene regulation of thousands of developmental genes by Polycomb group proteins. However, it is still unclear how Polycomb complexes can target to selective genes in a spatiotemporal manner. Here, we will discuss the latest insights into Polycomb-dependent developmental processes in mammals.

mRNA translation network regulating eukaryotic biological process

organizer
Akio Yamashita (The University of the Ryukyus), Toshinobu Fujiwara (Kindai University)

Detail

It is widely accepted that translational control plays a significant role in a range of diverse biological processes and diseases. For example, development of mRNA vaccine relied heavily on the recent advances in mRNA translation including cap dependent translation and codon optimality. This symposium focuses on the role of the regulation of translation across a variety of fields related to biological processes including the development, integrated stress response and inflammation.

10th insect meeting

organizer
Kakeru Yokoi (The National Agriculture and Food Research Organization), Takeru Nakazato (National Institute of Technology and Evaluation)

Detail

The development of next-generation sequencing, RNAi, and genome editing brought about knowledge in insects at the genetic and molecular levels. The aim of this meeting is to promote to launch new research objectives in Entomology and Molecular biology through lectures from, and discussions with young researchers who perform unique and interesting research using insects. We will also invite those who have given lectures in the past meeting and ask them to give a talk on the progressions of the research they lectured previously.