1AW-06

December 1 (Wed) 09：00～11：15

GTP Resilience: the Potential of Life

E/J

Organizer: Yoshihisa Hirota (Shibaura Institute of Technology), Risa Kawaguchi (Cold Spring Harbor Laboratory)

While experiencing dramatic changes in the global environment and extreme conditions, organisms have expanded their “potential of life" and shown resilience to endure numerous stress conditions. In this workshop, we will focus on cellular energy, guanosine triphosphate (GTP), which has an emerging role in the resilience of life. We will discuss the principle of GTP-mediated resilience by gathering researchers from multiple fields, aiming to develop a new field of biology, “the Potential of Life".

1AW-07

December 1 (Wed) 09：00～11：15

Forefront of Cell Dynamics and Pathophysiology unraveling from “Matrix Biology"

E/J

Organizer: Yasuhiro Nakano (The University of Tokyo), Kei Hashimoto (Ochanomizu University)

The extracellular matrix (ECM) regulates cell differentiation, proliferation and aging, and also contributes the development and homeostasis of tissues. Interestingly, it has been reported that ECM relates to the pathogenesis of diseases, such as organ fibrosis and dementia. In this workshop, we will discuss the ECM function in cell dynamics, pathogenesis of fibrosis and dementia, and drug discovery for organ fibrosis. We hope that our workshop provides opportunities to recognize the importance of matrix biology.

1AW-08

December 1 (Wed) 09：00～11：15

Temporal and spatial dynamics of genome organization and function

E

Organizer: Takashi Fukaya (University of Tokyo), Yongdae Shin (Seoul National University)

Recent advances in imaging technologies have enabled us to visualize and quantify fundamental processes of gene regulation at the single-cell level. It is becoming increasingly clear that temporal and spatial changes in genome topology and nuclear microenvironment play crucial roles in the dynamic control of gene expression during development. In this workshop, we will discuss cutting-edge studies on the dynamics of transcriptional regulation, 3D genome topology and the function of liquid-liquid phase separation in the nucleus.

1AW-09

December 1 (Wed) 09：00～11：15

Frontiers in research on craniofacial morphogenesis in vertebrates

E/J

Organizer: Sachiko Iseki (Tokyo Medical and Dental University), Chisa Shukunami (Hiroshima University)

Craniofacial morphogenesis in vertebrates is a unique process that involves cranial neural crest and mesodermal mesenchyme, and associated with skeletogenesis and related soft tissue formation for brain protection and establishment of personal identity. In this workshop, we will focus on recent progress in understanding the molecular mechanisms of craniofacial morphogenesis.

1AW-10

December 1 (Wed) 09：00～11：15

Is your signal connected? The conditional information memory system determines cellular potential

E/J

Organizer: Naoko Hattori (National Cancer Center Research Institute), Mayumi Oda (Keio University)

In functional cells, epigenomic information maintains cellular identity by responding to both external signals and internal environments to selectively memorize cellular properties. Disruption of this memory system leads to developmental abnormalities and diseases. In this workshop, we will focus on how and which signals are memorized via epigenetic mechanisms and how these events alter cellular morphology and function.

1AW-11

December 1 (Wed) 09：00～11：15

Getting to the crux of gene expression mechanisms through chemical biology

E

Organizer: Daisuke Kaida (University of Toyama), Masahiko Ajiro (Kyoto University)

In eukaryotes, accurate gene expression is achieved through reciprocal regulation of transcription, RNA processing, and translation. Although numerous studies have been performed on gene expression mechanisms, recent studies using chemical biological techniques revealed tons of novel, surprising findings. In this session, we will discuss about new insights on gene expression mechanisms and therapeutic strategies by amending their defects.

1AW-12

December 1 (Wed) 09：00～11：15

Construction of (sub)cellular-sized structures and the implications of the sizes for molecules' functions and dynamics

E/J

Organizer: Akatsuki Kimura (National Institute of Genetics), Yuki Hara (Yamaguchi University)

Molecules that function in cells work locally inside specific spaces such as intracellular organelles. Each location has the physical constraint of being "confined in a micrometer-scale space." The effect of space size on the molecules inside it is not fully understood. Also, the mechanism by which nanometer-scale molecules control the size of micrometer-scale structures is not clear. In this workshop, researchers who are focusing on the spatial size in living cells, on size control in reconstruction systems, and on theories behind the controls will introduce their works.

1AW-13

December 1 (Wed) 09：00～11：15

New functions of blanched-chain amino acids

J

Organizer: Tomoyoshi Soga (Keio University), Takahiro Ito(Kyoto University)

Recently, the branched-chain amino acids (BCAA), leucine, isoleucine and valine, have attracted much attention as functional molecules. BCAA play crucial roles in cancer cell growth and maintaining cancer stem cell. On the other hand, a brown adipose tissue (BAT)-specific defect in BCAA catabolism leads to diet-induced obesity and glucose intolerance. In this workshop, researches present molecular mechanisms how BCAAs are associated with these phenomena.

1AW-14

December 1 (Wed) 09：00～11：15

New frontier for protein assembly

E/J

Organizer: Tomohide Saio (Tokushima University), Masaki Okumura (Tohoku University)

Proteins exist in variety of “states" depending on folding, oligomerization, phase separation, and amyloid fibril formation. Despite the functional importance, the behavior and regulatory mechanisms of proteins and protein assemblies are poorly understood. Therefore, we will introduce the new aspects of protein assembly from a multidisciplinary perspective, such as organic chemistry, structural biology, biophysics, and cell biology, by cutting-edged young researchers.

1AW-15

December 1 (Wed) 09：00～11：15

Translational control is a potential therapeutic target to cure a variety of diseases

E

Organizer: Akiko Yanagiya (Okinawa Institute of Science and Technology), Tommy Alain (University of Ottawa)

Protein synthesis or mRNA translation is a defining process in life. Targeted control of this essential machinery influences cellular growth and metabolism, and enables cells to maintain homeostasis in response to environmental changes such as altered nutrients and viral infection. Dysregulations in protein synthesis cause a variety of diseases including cancer, diabetes, dementia, infertility and impaired immune response. The initiation of translation is often referred as the rate-limiting step in the formation and activity of translational complexes but importantly, this process that can be targeted for therapeutic purposes. This workshop will discuss potential approaches of targeting mRNA translational control for the treatment of diseases.

1AW-18

December 1 (Wed) 09：00～11：15

Primary cilium-mediated signal transduction and its related disorders

E/J

Organizer: Tatsuo Miyamoto (Hiroshima University), Yohei Katoh (Kyoto University)

Primary cilia contain a variety of receptors and channels to serve as a hot “field" for the signal transductions. Recently, it has been explored that cilia-related gene dysfunction underlies not only “rare" ciliopathies characterized with polycystic kidney but also “common" diseases such as cancers and obesity. Based on the findings using functional genomics and super-resolution microscope technology, we attempt to understand the physiological and pathological roles of primary cilia-mediated signal transductions.

1PW-02

December 1 (Wed) 15：45～18：00

Advanced molecular biology of disease pathophysiology revealed by "nuclear and mitochondrial research"

E/J

Organizer: Tomoaki Tanaka (Chiba University), Tohru Minamino (Juntendo University)

Advanced molecular biology research on mitochondria, coupled with nuclear events that are central to transcription, translation, and epigenomic regulation mechanisms, will be the key to reveal the mystery of life, namely “life-aging-disease-death". From the viewpoint of life span, aging signals such as telomeres, DNA damage, oxidative stress, sirtuins, nutrition and metabolism are commonly concentrated in the nucleus and mitochondria. In this workshop, with the theme of "Pathophysiology Molecular Research on Nucleus and Mitochondria," we will introduce pioneering studies that have opened up disease pathophysiology from the perspective of transcriptional control and metabolic regulation through new approaches such as single cell analysis, complex analysis and trans-omics analysis. I would hopefully like to deepen our discussion on the molecular biology of “life-aging-disease-death" from the viewpoint of synergy between nucleus, mitochondria and technology.

1PW-03

December 1 (Wed) 15：45～18：00

Enhanced Biology

E/J

Organizer: Yosuke Tanaka (The University of Tokyo), Tetsuya Kadonosono (Tokyo Institute of Technology)

In order to overcome age-related cell dysfunction and diseases in an aging society and adapt to and survive in unknown environments such as the warming earth and the space, we must enhance individual cell functions and the whole body. To this end, we need to study how to enhance individual cell functions and develop its basic technologies. In this workshop, we will specialize in the issue of enhancing technology, and introduce advanced researches that dispel the conventional biological common sense.

1PW-04

December 1 (Wed) 15：45～18：00

The merits and demerits of DNA replication stress tolerance: Genomic instability and cellular adaptation

E/J

Organizer: Bunsyo Shiotani (National Cancer Center Research Institute), Masatoshi Fujita (Kyushu University)

“Replication stress" is a broad term that refers to any condition that leads to the hindrance of DNA replication forks or the perturbation of replication dynamics, and is a source of genomic abnormalities, which leads to various biological phenomena and diseases. In this workshop, we would like to discuss the molecular basis and significance of genome instability and genome evolution deciding cell fate, focusing on DNA replication adaptation/tolerance mechanisms against chronic, non-transient DNA replication stress, and chromatin dynamics caused by internal and external factors.

1PW-05

December 1 (Wed) 15：45～18：00

Proteomics-based studies to clarify the molecular pathomechanism in psychiatric and neurological disorders

E/J

Organizer: Tomoyuki Yamanaka (Niigata University), Tetsuo Ohnishi (Tokyo Medical and Dental University)

Protein aggregation is the pathological hallmark of many neurodegenerative diseases, and proteomics has largely contributed toward the understanding of disease pathomechanisms. The comprehensive approaches have further identified significant proteomic alterations even in psychiatric disorders despite no apparent pathological phenotypes. This workshop will introduce the studies using advanced proteomic techniques to clarify the molecular pathomechanism of these diseases.

1PWS1-06

December 1 (Wed) 15：45～17：15

Cutting-edge research on α-tubulin detyrosinating enzyme, Vasohibin family

J

Organizer: Yasuhiro Suzuki (Tohoku University), Yutaka Furutani (RIKEN )

Detyrosination of α-tubulin C-terminal tail is a post-translational modification of microtubules and is associated with various cellular functions and diseases. The two members of Vasohibin family, VASH1 and VASH2, form a heterodimer with small vasohibin binding protein (SVBP) and function as αtubulin detyrosinating enzyme. This workshop will introduce cutting-edge research on Vasohibin family.

1PWS2-06

December 1 (Wed) 17：30～19：00

Membrane dynamics in sexual reproduction: functions and molecular mechanisms

J

Organizer: Shuh-ichi Nishikawa (Niigata University), Daisuke Maruyama (Yokohama City University)

Structures of cellular membranes change dramatically during sexual reproduction. Recent findings such as elimination of the paternal mitochondria by autophagy as well as the fusion between synergid and endosperm cells revealed that cellular membrane dynamics play important roles in sexual reproduction in animals and plants. In this workshop, we will discuss the functions and molecular mechanisms of cellular membrane dynamics that support sexual reproduction.

1PWS1-07

December 1 (Wed) 15：45～17：15

Synthetic Biology Reveals Mysteries of Life Evolution

J

Organizer: Sota Yagi (RIKEN), Mariko Harada (University of Tsukuba)

“How life emerged on earth?" This question is one of the ultimate mysteries of life science. The earliest life is thought to have occurred 3.5 to 4 billion years ago, but fossil information from that time is limited, making it difficult to know about early life. Synthetic biology provides a new perspective on evolution by experimentally reproducing ancient life molecules and systems. In this workshop, we will discuss the evolution of life revealed by the latest synthetic biology approaches.

1PWS2-07

December 1 (Wed) 17：30～19：00

Effect of liquid-liquid phase separation on sequential enzymatic reaction

J

Organizer: Tsutomu Mikawa (RIKEN), Kentaro Shiraki (University of Tsukuba)

Sequential enzymatic reactions as shown in metabolic systems do not proceed efficiently in vitro. On the other hand, the sequential reactions proceed efficiently in cells. For enzymes, cells are huge and contain many molecules that are unrelated to the sequential reactions. Nevertheless, how do these reactions efficiently proceed in the cell? In this workshop, we would like to focus on the relationship between liquid-liquid phase separation, which has been found to efficiently promote various biological phenomena, and sequential enzymatic reactions.

1PWS1-08

December 1 (Wed) 15：45～17：15

Innovative imaging technology uncovers novel vascular functions

J

Organizer: Hiroyasu Kidoya (University of Fukui), Tomohisa Sakaue (Ehime University)

The fusion of in vivo imaging and innovative technologies such as genome editing and optogenetics have enabled breaking through the limitation of modern vascular biology as well as oncology and cardiology. In this workshop, we introduce the exciting visual images regarding vascular functions using various and sophisticated imaging technology, and hope that we can discuss newly uncovered vascular roles.

1PWS2-08

December 1 (Wed) 17：30～19：00

Recent Advances in Electron Microscopic Imaging

J

Organizer: Isei Tanida (Juntendo University), Daisuke Koga (Asahikawa Medical University)

Electron microscopic imaging is developing according to new techniques and instruments. Osmium maceration method and in-lens SEM result in the new insight of super-imaging of organelles. FIB-SEM reveals the 3D ultrastructures of biological materials. CLEM is also developed to in-resin CLEM with a highly accurate correlation. In this workshop, recent advances in electron microscopic imaging are picked up, and future aspects in this field will be discussed.

1PWS1-09

December 1 (Wed) 15：45～17：15

Aptamer research on the front line

J

Organizer: Taiichi Sakamoto (Chiba Institute of Technology), Masaki Takahashi (The University of Tokyo)

Recently, lots of nucleic acid therapeutics have been approved and are expected as one of the therapeutic modalities. Aptamers are nucleic acid molecules that have high specificity and affinity for various target molecules including low molecular weight compounds and proteins, and aptamer therapeutics are different from other nucleic acid therapeutics at the point of their mechanism of action and development method. In this workshop, we will discuss about aptamer development and their applications.

1PWS2-09

December 1 (Wed) 17：30～19：00

Bioresource of the year 2021

J

Organizer: Yoshihiro Miwa (RIKEN), Yukio Nakamura (RIKEN)

Many newly developed bioresources such as tools and libraries made various breakthrough in life science field. Though some bioresources developed by Japanese scientists are used by many researchers in the world and a lot of papers reported, they are rarely used by Japanese researchers. Therefore, in this workshop we will accept more applications than usual and share recent information for new bioresources to accelerate the use of them.

1PWS1-10

December 1 (Wed) 15：45～17：15

Skeletal muscle cell research for anti-aging - Molecular biological basis for human evolution

J

Organizer: Yoriko Atomi (Tokyo University of Agriculture and Technology), Atsushi Asakura (University of Minnesota Medical School)

Multicellular terrestrial animals have a two-layered developmental system principle of cells and body and survive in an activity-dependent manner. The adaptation of the skeletal muscle developed by the self-organizing/reflex system due to dynamic instability is carried out by the anti-gravity muscle, which is mechanically and metabolically unstable. Voluntary movements by skeletal muscles as organs for physical activities that humans have constructed through the neural control system in the upright position have created a body structure adaptively linking micro (proteins) and macro (central nervous system). In this workshop, we will discuss the fundamental principles that have led to the evolution of not only the improvement of human QOL but also the evolution of human beings as an essentially unique existence, from various perspectives, including development, regeneration, and physical techniques, which failure leads to the aging phenotypes.

1PWS2-10

December 1 (Wed) 17：30～19：00

Frontier researches on cytoskeletal dynamics and cell migration

E/J

Organizer: Sawako Yamashiro (Kyoto University), Yukako Nishimura (Hokkaido University)

The cytoskeleton is a dynamic structure that integrates chemical signaling and mechanical forces in response to intra- and extra-cellular environment. Recent technical advances, from in vitro reconstitution to in vivo quantitative imaging and cellular engineering, provide us with new insights for mechanical functions of cytoskeletal dynamics and cell migration. This workshop will highlight the latest advancement by early-career scientists and discuss a future perspective in this emerging field.

1PW-11

December 1 (Wed) 15：45～18：15

EMBO | Japan Virtual Lectures: How do piRNAs defend the germline genome from invasive transposons?

E

Organizer: Kuniaki Saito (National Institute of Genetics)
EMBO | Japan Virtual Lectures: Abstract & CV

1PW-12

December 1 (Wed) 15：45～18：00

Higher biological function of NAD-dependent enzymes ~beyond energy metabolism~

E/J

Organizer: Takashi Nakagawa (University of Toyama), Katsuhiko Ishihara (Kawasaki Medical School)

Nicotinamide adenine dinucleotide (NAD) has been discovered as a coenzyme that mediates redox reactions over 100 years ago. It also serves as a substrate for DNA repair enzyme PARP and aging-related molecules, sirtuins. Therefore, NAD is gathering attention again due to association with aging. In this workshop, we will discuss the functions of these NAD-dependent enzymes from a wide range of fields such as aging, intestinal microbiota, metabolic diseases, and neuropsychiatric disorders, and go beyond the energy metabolism.

1PW-13

December 1 (Wed) 15：45～18：00

Intracellular molecular mechanism revealed by proteomics -from beginners to experts-

J

Organizer: Mio Iwasaki (Kyoto University), Norie Araki (Kumamoto University)

Recent advances in innovative proteomics technologies enable highly sensitive/accurate analyses of not only simple cellular protein expressions but also the post-translational modifications and protein localization / interactions, etc. Proteomics has achieved a great success in wide areas of the molecular biology. In this session, innovative cellular functional proteomics with the cutting-edge technology development and successful applied research examples will be introduced, mainly by young researchers who are expected to be the most responsible in this field in near future.

1PWS1-14

December 1 (Wed) 15：45～17：15

Predicting Evolutionary Outcome: from RNA to Eco system

J

Organizer: Naoki Irie (The University of Tokyo), Chikara Furusawa (RIKEN)

The main focus of Evolutionary biology has been events happened in the past, and was similar to the field of History. However, recent studies tackle further challenging topics such as evolvability and prediction of evolution. In this workshop, we would like to introduce the researches that tackle this problem by combining theoretical, experimental, and bid data analyses approaches. We welcome broad discussions suggestions from the audience.

1PWS2-14

December 1 (Wed) 17：30～19：00

Epigenetic regulatory networks in stem cells

E/J

Organizer: Hirotsugu Ishizu (Keio University ), Akihiko Sakashita (Keio University)

The fertilized egg or zygote is a totipotent stem cell, which has the ability to differentiate into all the cell types found in an individual. How does a fertilized egg acquire totipotency? Recent advances in early embryonic development and stem cell reprogramming studies have revealed dynamic changes in genome structure that are responsible for resetting and reconstructing epigenetic information. However, the programming transition from totipotent to pluripotent state during embryogenesis remains to be fully elucidated. In this workshop, we will share the latest findings on the regulatory mechanisms of the epigenome that define the differentiation and self-renewal capabilities of stem cells, and discuss the challenges to elucidate the epigenetic regulatory network behind the acquisition of totipotency.

1PWS1-15

December 1 (Wed) 15：45～17：15

Methylation biology -Understanding Life Phenomena Linked to RNA Methylation-

E/J

Organizer: Masamitsu Konno (Tokyo University of Science), Keisuke Hitachi (Fujita Health University)

Recent studies have revealed that mRNAs and miRNAs are more methylated than DNA, and the importance of RNA methylation in understanding life phenomena has been highlighted. In this workshop, the speakers will present new analytical methods and tools that are expected to be important in the future for the study of RNA methylation, providing an opportunity for newcomers to this field and further development of this field.

1PWS2-15

December 1 (Wed) 17：30～19：00

AMED-BINDS initiatives to promote academia drug discovery research Co-hosted by: Basis for Supporting Innovative Drug Discovery and Life Science Research(AMED)

J

Organizer: Masaru Tanokura (The University of Tokyo), Tatsuya Zenkoh (Japan Agency for Medical Research and Development)

In the BINDS project managed by AMED, we have established a platform to help promote life science research. For example, we have prepared and maintained large facilities and equipments such as synchrotron radiation facilities, cryo-electron microscopes, compound libraries, and next-generation sequencers, and actively open them to the outside (shared) to contribute to the promotion of life science research such as drug discovery. In this workshop, we would like to announce the results of our efforts to promote academia drug discovery at AMED-BINDS project and use it as a place to discuss the further development of academia drug discovery in the future.

1PW-18

December 1 (Wed) 15：45～18：00

Intercellular communication in the control of organ morphogenesis in animals and plants

E/J

Organizer: Yuki Kondo (Kobe University), Takaaki Matsui (Nara Institute of Science and Technology)

Various ways of cell-cell communication are used to ensure the morphogenesis of multicellular organisms. While plant cells cannot move around like animal cells, they are connected intracellularly via plasmodesmata. In this workshop, we will discuss the similarities and differences between animals and plants in cell-cell communication.

2AW-06

December 2 (Thu) 09：00～11：15

Membrane protein targeting and quality control in organelle biogenesis

E

Organizer: Yukio Fujiki (Kyushu University), Shunsuke Matsumoto (Kyushu University)

Correct targeting of newly synthesized proteins to their destined compartments is essential for cell functions. The protein targeting is thought to be achieved with high fidelity accompanying quick degradation of incorrectly localized proteins. However, recent findings show that cells equip novel proofreading systems by which the mislocalized proteins can reach their original destination. We will discuss such a newly discovered system in membrane protein targeting and quality control.

2AW-07

December 2 (Thu) 09：00～11：15

Involvement of neurons-glia interactions in the brain formation during development

E

Organizer: Fuminori Tsuruta (University of Tsukuba), Tomohiko Okazaki (Hokkaido University)

In the developing brain, various cells such as glia contribute to a precise neural circuit formation. Recent advanced researches based on molecular genetic techniques and high-resolution imaging approaches have emerged that neuron-glia interaction produced a diversity of glia, contributing to brain formation. Here, we introduce the mechanisms of how xenogeneic cellular communication among neurons and glia contributes the brain formations through glial diversity during development. In this workshop, we would like to suggest a new perspective on the biological relevance that underlies the brain formation regulated by neuron-glia interaction.

2AW-08

December 2 (Thu) 09：00～11：15

Multifaceted strategies for keeping mitochondria strong and healthy

E

Organizer: Koji Yamano (TMIMS), Ying Liu (Peking University)

Mitochondria are not simple ATP-producing power plants but play pivotal roles in numerous biological functions in eukaryotic cells. Recent studies have been uncovering multifaceted functions to build and keep mitochondria strong and healthy. In this session, we would like to introduce and discuss recent progress in mitochondrial homeostasis, which will pave a way for new therapeutic approaches for metabolic syndromes and neurodegenerative disorders.

2AW-09

December 2 (Thu) 09：00～11：15

Toward coherent design of host bacterial symbiosis

E

Organizer: Nobuo Sasaki (Gunma University), Shinji Fukuda (Keio University)

Trillions of varying bacteria colonized symbiotically with any animal tissues such as the intestine and skin. Previous studies have revealed that a symbiotic bacteria-host relationship has a pivotal role to maintain host tissue homeostasis. Unfortunately, we still have not been able to control the microorganism and host homeostasis freely because bidirectional signals within the symbiosis are still largely unknown. In this workshop, we present pathogenic mechanisms related to dysbiosis and the function of bacteria-derived metabolites, and we will also discuss the future of how to design the personalized ecosystem.

2AW-10

December 2 (Thu) 09：00～11：15

Interface of metal medical biology and advanced analytical technologies

E

Organizer: Toshiyuki Fukada (Tokushima Bunri University ), Taiho Kambe (Kyoto University)

The essential trace elements including zinc and iron play in many biological processes via regulating molecules like transcription factors, enzymes. In this workshop, we will address recent advances in metal medical biology and new analytical technologies such as in vivo metal-imaging. We will also discuss strategies how to apply the advanced analytical methods to further understanding of metal medical biology: an emerging life science research field.

2AW-11

December 2 (Thu) 09：00～11：15

Investigating cellular diversity by multi-scale single cell analyses Co-hosted by: Integrated analysis and regulation of cellular diversity

E

Organizer: Yuichiro Nakajima (Tohoku University), Satoshi Takagi (Japanese Foundation for Cancer Research)

Tissues and organs in vivo are composed of diverse cell populations, or "cellular diversity", which enables the robust development and maintenance of homeostasis while defects in such diversity lead to diseases such as cancers. We will introduce recent research progresses towards understanding of cellular diversity by integrating multi-scale single-cell analyses, including scRNA-seq, tissue-clearing, and cellular barcoding.

2AW-12

December 2 (Thu) 09：00～11：15

Frontiers in cellular responses on the edge of death

E

Organizer: Kenta Moriwaki (Toho University), Toru Okamoto (Osaka University)

How do cells behave when they are on the edge of death? This workshop will bring together up-and-coming researchers who are interested in cellular responses against intrinsic defects of biological macromolecules such as carbohydrates, lipids, and proteins or extrinsic enemies such as bacteria and viruses. These speakers will share their latest findings, which we believe will be of interest to many attendees.

2AW-13

December 2 (Thu) 09：00～11：15

What is the individuality of plants

E

Organizer: Junko Kyozuka (Tohoku University), Shinichiro Sawa (Kumamoto University)

In plants, the concept of ‘individual' is ambiguous. It may be more appropriate to think that the individuals we see are ostensible individuals, and that they are only a collection of true ‘individuals'. In this WS, we will examine the unique patterns of plant growth and proliferation at the molecular level as a first step toward understanding what is the true individuality of plants.

2AW-14

December 2 (Thu) 09：00～11：15

Notch signaling in biological processes

E

Organizer: Tomoko Yamakawa (Osaka University), Hiromi Shimojo (Osaka University)

Notch signaling is conserved in multi-cellular organisms and have important roles in development and homeostasis. Recent Notch signal research has developed dramatically and been trying to take a new step with surprise. In this workshop, we will introduce impactful studies to deepen our understanding of complex biological processes through the elucidation of various control mechanisms of Notch signaling.

2AW-15

December 2 (Thu) 09：00～11：15

Toward an understanding of complex biochemical systems from a phase separated compartment, “nucleolus"

E

Organizer: Satoru Ide (National Institute of Genetics), Noriko Saitoh (Japanese Foundation for Cancer Research)

The nucleolus is the most prominent nuclear body and forms around ribosomal RNA genes with abundant proteins and RNAs. How do various nuclear events take place in the crowding environment? This is a key question to fill the gap between in vitro chemical reactions and complexed networks in organisms. Based on the recently advanced view of the nucleolus as a multiphase liquid condensate, we discuss on its reaction networks and diverse nucleolar processes involved in biology and human diseases.

2AW-18

December 2 (Thu) 09：00～11：15

Genome modality: understanding physical properties of the genome Co-hosted by: Genome modality: understanding physical properties of the genome

E

Organizer: Tetsuya Yamamoto (Hokkaido University), Ikuko Motoike (Tohoku University)

The structure and dynamics of genome is regulated by the interactions with various proteins and play an important role in some functions of genome, such as the regulation of gene expression. In this workshop, we will discuss the structure and dynamics of genome in different length scales, ranging from the nucleosome to the chromosome levels, to understand the mechanism involved in the functions of genome.

2PW-02

December 2 (Thu) 15：45～18：00

Scientific verification of biological effects of aerosols and droplets in the air

E

Organizer: Tatsuya Mimura (Teikyo University), Yasuhiro Yoshida (University of Occupational and Environmental Health)

With the spread of COVID-19 infection, infection by fine particles and droplets in the air is drawing attention. In addition to aerosols containing microdroplets and viruses, particles such as pollen, air pollutants, chemical substances, tobacco dust, pets, mites, and fungi are suspended in the atmosphere. These invisible particles have biological effects on the respiratory, circulatory, reproductive, and sensory organs.In this lecture, experts on respiratory organs, allergies / immunological disorders, microorganisms / infections, aging, and sensory organs will scientifically discuss the pathogenic mechanism and countermeasures of biological effects.

2PW-03

December 2 (Thu) 15：45～18：00

Inflammaging, taking lessons from history Co-hosted by: Japan Society for Biomedical Gerontology

E

Organizer: Mitsuo Maruyama (National center for Geriatrics and Gerontology), Takahiko Shimizu (National center for Geriatrics and Gerontology)

Tissue damage caused by oxidative stress is accompanied by chronic inflammation, and the inflammaging theory has been proposed over the years. Recently, it is becoming clear that SASP secreted by senescent cells causes inflammation throughout the body and contributes to the promotion of age-related diseases. In this workshop, we would like to introduce and consider the latest findings on how inflammatory stress from inflammaging to SASP controls aging. This workshop will be co-hosted with the Japan Society for Biomedical Gerontology.

2PW-04

December 2 (Thu) 15：45～18：00

What drive the species-specific traits?

J

Organizer: Yukako Hattori (Kyoto University), Shinichi Nakagawa (Hokkaido University)

Individual species have acquired a wide variety of traits during evolution. Recent technological advances such as genome editing and large-scale sequencing have made it possible to approach the molecular mechanisms that give rise to these traits. This workshop will focus on the molecular basis underlying species-specific traits from a viewpoint of molecular biology and evolution. To this end, we plan to have presentations by researchers who are addressing mechanistic questions regarding these issues through comparative analyses among species, including non-model organisms, and analyses of species-specific genes and non-coding RNAs.

2PWS1-05

December 2 (Thu) 15：45～17：15

New trend of cardio oncology and its molecular mechanism

J

Organizer: Yasunari Kanda (National Institute of Health Sciences), Hiroshi Hosoda (National Cerebral and Cardiovascular Center Research Institute)

The development of anti-cancer drugs brings both improved survival and cardiotoxicity to cancer patients. Cardio-oncology has emerged as a new discipline with the aim of best managing cardiovascular complications. Recently new responsiveness of cardiomyocytes to drug-induced cardiotoxicity has been turned out. In this workshop, we will invite top scientists to discuss a range of hot topics, including mechanism of drug-induced cardiotoxicity and strategies for its prevention.

2PWS2-05

December 2 (Thu) 17：30～19：00

The Principles of Life Sciences “Mitochondria Dynamics"

E/J

Organizer: Tsuyoshi Osawa (The University of Tokyo), Yusuke Hirabayashi (The University of Tokyo)

The maintenance of mitochondrial homeostasis and interaction between mitochondria and other organelles (organelle interaction) through metabolites (organelle communication) play important roles in the progression of diseases such as cancer and metabolic diseases and aging. It is also known that the balance between mitochondrial fusion and division maintains mitochondrial function, while its dysregulation promotes aging and diseases. However, the detailed mechanism of mitochondrial fusion and division are not fully elucidated. In this workshop, young researchers in the mitochondria filed will gather to introduce the mechanism of “mitochondrial dynamics" that is the principles of life, using advanced imaging and structural biology analysis technologies. This workshop also provides an opportunity for new entrants.

2PWS1-06

December 2 (Thu) 15：45～17：15

Ｇenome biology with genomics databases

E

Organizer: Hideya Kawaji (Tokyo Metropolitan Institute of Medical Science)

A series of genomics data, such as genome diversity, epigenome, and transcriptome have been increasingly accumulated, covering novel data types produced by cutting-edge technologies as well as constant improvements of baseline data. We would like to overview recent updates in the field and discuss genomic aspects found in those data.

2PWS2-06

December 2 (Thu) 17：30～19：00

Dysregulation of protein complexes and the development of cancer

J

Organizer: Takashi Ito (Nagasaki University), Satoshi Inoue (Tokyo Metropolitan Institute of Gerontology)

Many important cellular processes are driven by protein complexes. In order for the complex to function at the right time and under the right conditions, the appropriate levels of active complex need to be maintained by regulation. The dysfunction of complexes leads to miscellaneous diseases, including cancer. However, in most cases the mechanisms regulating complexes remain unclear. In this session we focused on these mechanisms and how their perturbation is related to cancer development.

2PWS1-07

December 2 (Thu) 15：45～17：15

New national disorder, chronic kidney disease, elucidated by the molecular mechanisms

E/J

Organizer: Imari Mimura (The University of Tokyo), Seiji Kishi (Kawasaki Medical School )

Chronic kidney disease (CKD) is a new national disorder because one out of eight adults in Japan have as well as adult-onset diseases. More than 13 million people have CKD, a part of whom lead to end-stage renal diseases. Various kinds of cells in the kidney cooperates to eliminate wastes of blood and excessive body fluid though the step of dialysis. Regrettably, over 30 years fundamental new therapies against CKD have not been developed although intensive basic research has been evolved so far. Japanese Society of Nephrology has also undertaken the task of clarifying the kidney disease processes and analyzing the pathological stages of kidney diseases at full power. In this workshop, the latest results of basic research will be introduced by young investigators against kidney diseases. We can expect that new insights into novel discovering the molecular mechanisms of kidney diseases will lead to the novel application for other fields.

2PWS2-07

December 2 (Thu) 17：30～19：00

A role of glycation in immune responses and aging-associated diseases Co-hosted by: Japanese Maillard Reaction Society

J

Organizer: Kazunori Sango (Tokyo Metropolitan Institute of Medical Science), Tomoko Oya-Ito (Shubun University)

Advanced glycation endproducts (AGEs) accelerates the development and progression of aging-associated diseases, such as diabetic complications and osteoporosis. In addition, post-translational modification of proteins by the precursors of AGEs (e.g., methylglyoxal and glycolaldehyde) plays a key role in immune responses and age-related disorders. In this workshop, young investigators will present their latest exciting advances regarding these topics.

2PW-08

December 2 (Thu) 15：45～18：00

Cell division in diverse contexts

E

Organizer: Masatoshi Hara (Osaka University), Tomomi Kiyomitsu (OIST)

The basic principles of cell division have been established mainly through studies using cell culture models. However, recent work in different biological contexts has revealed a considerable diversity in cell division mechanisms. This workshop gathers researchers exploring the regulation of cell division in various contexts to deepen our understanding of the diversity and universality of cell division.

2PW-09

December 2 (Thu) 15：45～18：00

What is life in a microbe?

E

Organizer: Shogo Ozaki (Kyushu University), Setsu Kato (Hiroshima University)

What is “being alive" for a microbe? While proper cell cycle progression is vital for individual cells, unique actions of a subpopulation of cells have a substantial impact on maintaining the population's homeostasis. In this workshop, we aim to understand such a complicated form of a microbial life from different perspectives, including the state-of-the-art molecular biology, cell biology, bioinformatics, and systems biology. Together, we expect to provide a novel insight into the definition of life.

2PWS1-10

December 2 (Thu) 15：45～17：15

Recent advances in structural biology

E/J

Organizer: Nishimasu Hiroshi (The University of Tokyo), Tomohiro Nishizawa (Yokohama City University)

Recent advances in single-particle analysis by cryo-electron microscopy have enabled the structural determination of large, flexible supramolecular complexes at high resolution, which has been challenging in the past. In this workshop, we would like to discuss mechanistic insights provided by the structural analysis of proteins and protein-nucleic acid complexes that are involved in important biological processes but have not been structurally characterized.

2PWS2-10

December 2 (Thu) 17：30～19：00

4th Cryo-EM network user group meetingCooperation: AMED-BINDS

J

Organizer: Takeshi Murata (Chiba University), Naruhiko Adachi (High Energy Accelerator Research Organization )

The cryo-EM network, a system to support cryo-EM users, is now in full-scale operation, and researchers who have no experience using cryo-EM are now ready to use the most advanced cryo-EM. In this workshop, not only existing users but also researchers who want to use cryo-EM in the future, as well as researchers from the cryo-EM sites, will gather to discuss the use of cryo-EM equipment from various perspectives in order to make more effective use of the cryo-EM equipment that has been installed throughout Japan.

2PWS1-11

December 2 (Thu) 15：45～17：15

Recent advances and issues in neurobiological proteostasis

J

Organizer: Shuji Wakatsuki (National Center of Neurology and Psychiatry), Gen Matsumoto (Nagasaki University)

Keeping protein homeostasis, or proteostasis, is critical in neurons. Imbalance of proteostasis leads to the dysfunction of signaling or protein turnover causing many intractable neurological diseases. In this workshop, we will invite leading scientists to share recent advances in neuronal proteostasis and the pathogenetic mechanisms of neuronal disorders, and discuss about them in neurobiological perspectives.

2PW-12

December 2 (Thu) 15：45～18：00

Interactions between neural cells and immigrant cells during the development and aging in the brain

E

Organizer: Hidenori Tabata (Institute for Developmental Research, Aichi Developmental Disability Center), Yuki Hattori (Nagoya University)

Brain is a special organ isolated from the other part of body. However, recent studies have revealed that, during the development of brain, extrinsic cells such as endothelial cells and immune cells invade in the brain and provide special niches and positional information to break the uniformity of the neural tissues. Moreover, these immigrant cells play pivotal roles for homeostasis of the brain in the adulthood, and the abnormality of them can lead psychiatric diseases. In this workshop, we will introduce unexpected relationship between neural cells and immigrant cells, and discuss basic biology of their roles and applications for clinical interventions.

2PW-13

December 2 (Thu) 15：45～18：00

TAISHITSU Science from the viewpoint of Artificial Energy-Saving TAISHITSU models

E

Organizer: Takahiro Nemoto (Nippon Medical School), Tomoko Kawai (National Center for Child Health and Development)

The definition of "TAISHITSU" is still ambiguous. It has been hypothesized that low birthweight due to malnutrition during the fetal period results in a thrifty (a.k.a. energy-saving) TAISHITSU. Focusing on artificial energy-saving TAISHITSU models, we would like to discuss vertically and cross-cuttingly various organisms, from epigenome to metabolism.

2PW-14

December 2 (Thu) 15：45～18：00

Small is beautiful: a huge variety of biological fine particles existed in a living body

E

Organizer: Yosuke Tashiro (Shizuoka University), Tomoyoshi Yamano (Kanazawa University)

Fine particles including exosomes have been attracting attention in recent years because of their relationship with cancer and diseases. However, various fine particles are formed from a broad range of cells and microorganisms in a living body. In this workshop, young researchers will introduce the physiological functions of various biological fine particles and discuss their universality and individual characteristics. We would like to make it a place to reconsider the significance of fine particles in our body.

2PWS1-15

December 2 (Thu) 15：45～17：15

RNA and phase separation: an inseparable relationship

E

Organizer: Hiroya Yamazaki (The University of Tokyo), Tomohiro Yamazaki (Osaka University)

RNA is an indispensable molecule in the formation and function of intracellular phase separation in various aspects. In this workshop, we discuss multiple functional relationships between RNA and phase separation in several species among animals and plants by bringing up topics including the mechanisms of biogenesis and function of microRNAs and piRNAs through phase separation and formation of phase-separated condensates driven by lncRNAs.

2PWS2-15

December 2 (Thu) 17：30～19：00

Fathoming the operation principle of the genome by establishing platform technologies Co-hosted by: JST CREST/PRESTO "Genome Programming"

E/J

Organizer: Haruhiko Siomi (Keio University), Kayo Nozawa (The University of Tokyo)

In this workshop, we introduce new technologies that would allow us to solve the principle of functional genomics in view to establish a future platform technology for genome programming.

2PWS1-18

December 2 (Thu) 15：45～17：15

The World of SLFN11

E/J

Organizer: Junko Murai (Keio University), Minoru Takata (Kyoto University)

Schlafen 11 (SLFN11) was first reported in 2012 as its expression is highly correlated to the drug sensitivity of a broad type of DNA damaging agents. Since the discovery, mechanisms of action of SLFN11 and clinical implications of SLFN11 have been accumulated. SLFN11 seems to exist in human genome but not in mouse genome. How lucky the human being is who acquired the SLFN11! Yet, what are the functions of SLFN11 in nature? Do not miss this WS where you will realize the new world with SLFN11!

2PWS2-18

December 2 (Thu) 17：30～19：00

Genome functions mediated by transposable elements

J

Organizer: Jafar Sharif (RIKEN), Hidenori Nishihara (Tokyo institute of technology)

Packaging of the chromatin fiber into 3D nuclear compartments (e.g. TADs) is associated with key genome functions such as DNA replication and recombination. Intriguingly, enrichment of specific types transposable elements (TEs), such as SINEs or LINEs, could determine the function of a nuclear compartment, a model that we propose as the transposable element code (TEC). In this workshop, we will address potential mechanisms and functions linked with TEC.

3AW-06

December 3 (Fri) 09：00～11：15

The molecular mechanism that disrupts genome stability and the genomic abnormalities caused by genome instability

E/J

Organizer: Shinichiro Nakada (Osaka University), Kouji Hirota (Tokyo Metropolitan University)

The detailed molecular mechanisms of various systems involved in maintaining genome homeostasis have been elucidated. However, there are still many biological phenomena that have not yet been elucidated, such as the molecular pathology of diseases caused by genome instability, and organ-specific carcinogenic mechanisms. In this workshop, we would like to discuss the possibility of developing new disease treatment methods using the genome maintenance system through the presentation of advanced research.

3AW-07

December 3 (Fri) 09：00～11：15

Functional RNA networks in homeostatic regulation

E/J

Organizer: Toru Suzuki (RIKEN), Takahisa Nakamura (Cincinnati Children's Hospital)

Post-transcriptional mechanisms regulate RNA stability, subcellular localization, and translation. RNA itself is involved in the regulation. We introduce recent studies examining how RNA-dependent molecular mechanisms contribute to organismal homeostasis. We discuss diverse researches focusing on general or cell type-specific mechanisms mediated by cellular or extracellular RNAs.

3AW-08

December 3 (Fri) 09：00～11：15

Molecular Biology of Aggregation-Regulation of Phase separation and Aggregation Formation Contributes to Risk Management of Cells-

E

Organizer: Riki Kurokawa (Saitama Medical University), Masato Katahira (Kyoto University)

Phase separation (PS) plays roles in divergent activities like production of droplets and membraneless organelles. Upon overactivity of PS, it induces aggregation (AG) of intrinsically disordered proteins, resulting in harmful effects. These AGs are focused as a cause for neurodegenerative diseases like ALS. Formation of AG is regulated to prevent its risk. Here, we plan marvelous talks by the young and the experts of the field. Active discussion will be expected.

3AW-09

December 3 (Fri) 09：00～11：15

New insight into the mechanism for skeletal muscle maintenance: toward the realization of healthy aging

J

Organizer: Akiyoshi Uezumi (Tokyo Metropolitan Institute of Gerontology), Satomi Nadanaka (Kobe Pharmaceutical University)

Skeletal muscle is the largest organ in the human body. It plays an essential role in health maintenance by functioning as metabolic organ in addition to musculoskeletal system. Age-related muscle weakness adversely affects general health. Therefore, maintaining muscle integrity should become a key to achieve healthy aging. In this workshop, we will introduce leading-edge research on muscle maintenance and provide new insight into the mechanism underlying skeletal muscle integrity.

3AW-10

December 3 (Fri) 09：00～11：15

Homochirality governs order of life; veritas of organisms reflected in the mirror

J

Organizer: Jumpei Sasabe (Keio University), Kenji Matsuno (Osaka University)

Objects are chiral when they cannot be superposed on their mirror images. Organisms rely on homochirality (a uniformity of chirality), which is achieved at the levels of molecules, cells, bodies, ecosystem, to form orderly in various biological systems. However, importance of homochirality has been overlooked, although homochirality is observed very broadly. In this workshop, we would like to discuss the roles of homochirality at such various levels. This workshop will provide a comprehensive view how homochirality governs the orderly in the various biological systems.

3AW-11

December 3 (Fri) 09：00～11：15

Reconstruction of the nucleus -Toward understanding chromatin, chromosomes, and cell nuclei by reconstruction approach - Supported by: Grant-in-Aid for Scientific Research on Innovative Areas, 'Chromatin Potential'

J

Organizer: Kazuo Yamagata (Kindai University), Tokuko Haraguchi (Osaka University)

The cell nucleus is a "magic box" needed to transform DNA, a "chemical material", into a "living organism (which performs controlled transcription and replication)." To understand this "magic" (the element that is truly necessary for nuclear functions) at the molecular level, it is important to reconstruct the cell nucleus using the defined element. In this workshop, researchers conducting reconstitute research at various hierarchy and methodology such as in vitro synthesis, nanotechnology, and artificial chromosome and nucleus construction in living cells will be gathered to discuss the construction of nuclear functions.

3AW-12

December 3 (Fri) 09：00～11：15

Challenges in Elucidating Life Phenomena by applying the Engineering-assisted Methods

E

Organizer: Yutaka Kikuchi (Hiroshima University), Mototsugu Eiraku (Kyoto University)

In recent years, ambitious attempts have been made to construct tissues and organs in vitro to elucidate complex life phenomena, and many results have been achieved in elucidating life phenomena such as development, disease, regeneration, and maintenance of biological functions. However, there are many problems for the construction of mature tissues and organs, such as shape maintenance, patterning, and expression of functions. In this workshop, we will introduce the latest studies on challenging the elucidation of biological phenomena through the engineering-assisted methods.

3AW-13

December 3 (Fri) 09：00～11：15

Next -generation nutritional science woven from integrative research

E/J

Organizer: Shin-Ichiro Takahashi (The University of Tokyo), Takafumi Miyamoto (University of Tsukuba)

In the advanced information processing system called "life," the spatial and temporal interplay of nutrients is responsible for carrying out a diversity of functions. However, in modern life sciences, specialized fields have been established for each individual nutrient, leaving no academic environment where the role of these nutrients can be explored comprehensively. Therefore, the purpose of this workshop is for researchers to share the latest findings on the functionality of glycans, lipids, amino acids, and other substances, to help facilitate a next generation of nutritional science that will be capable of reaching a systematic understanding of the functionality of nutrients in life.

3AW-14

December 3 (Fri) 09：00～11：15

Analyses of organelle autoregulation with new technologies of organelle manipulation

J

Organizer: Hiderou Yoshida (University of Hyogo), Shigeomi Shimizu (Tokyo Medical and Dental University)

The amount of organelles in eukaryotic cells is strictly regulated according to cellular demand by the mechanism called organelle autoregulation, which is one of the fundamental issues of cell biology. Recently, the development of new technologies has enables us to manipulate organelles in order to analyze their functions. In this workshop, we will present state-of-the art techniques of organelle manipulation as well as latest research on organelle autoregulation.

3AW-15

December 3 (Fri) 09：00～11：15

Single-cell dynamics

E

Organizer: Seitaro Nomura (The University of Tokyo), Hiroyuki Aburatani (The University of Tokyo)

The cell is a minimum functional unit of living organisms, and its function is regulated by spatio-temporal behavior of thousands of molecules. Recently, the development of innovative science and technology in single-cell omics, single-molecule super-resolution imaging, genome engineering, structural biology, and phase separation biology enables us to describe molecular behavior in the cell with high resolution. In this workshop, cutting-edge scientists will get together to discuss it from a multidimensional point of view, aiming to the establishment of a method to understand and regulate the underlying molecular mechanisms of various life phenomena.

3AW-16

December 3 (Fri) 09：00～11：15

Genomic DNA quantity matters: how changes in genomic DNA quantity impact the fate of living organisms

J

Organizer: Mariko Sasaki (The University of Tokyo), Miho Ohsugi (The University of Tokyo)

Genomes can change in multiple ways during cellular growth, development, aging, tumorigenesis and evolution. In this workshop, we will focus on changes in genomic DNA quantity that arise as a consequence of changes in copy numbers of repetitive elements, chromosome numbers, and ploidy. We will discuss the mechanisms that cause these changes as well as how they impact the fate of living organisms.

3AW-18

December 3 (Fri) 09：00～11：15

New Roles and New Morphology of Lysosomes

E

Organizer: Yui Jin (Tokyo Institute of Technology), Yoko Kimura (Shizuoka University)

The lysosome is an organelle that has variety of functions including degradation of macromolecules, nutrients storage, and maintaining osmotic pressure. Uniquely, the shape and size of this organelle change freely depending on the environment. However, there is no clear relationship between diverse shapes and roles of lysosome. To date, evidence of a range of new roles of the lysosome have been revealed, exceeding our previous knowledge. In this workshop, we will discuss the most recent research findings about this unique organelle among several species.

3PW-03

December 3 (Fri) 15：45～18：00

mRNA translational control in biological processes and disease

E/J

Organizer: Akio Yamashita (University of the Ryukyus), Toshinobu Fujiwara (Kindai University)

It is widely accepted that translational control plays a significant role in a range of diverse biological processes and diseases. For example, development of mRNA vaccine relied heavily on the recent advances in mRNA translation including cap dependent translation and codon optimality. This workshop focuses on the role of translation across a variety of fields related to biological processes including integrated stress response, development, inflammation and viral mRNA translation.

3PW-04

December 3 (Fri) 15：45～18：00

Novel mechanism of transcription regulation by spatiotemporal multifactor interactions

J

Organizer: Hidehisa Takahashi (Yokohama City University), Keisuke Nimura (Osaka University)

Appropriate regulation of gene expression is essential for cellular function. For such a precise regulation of gene transcription, a limited number of transcription regulators such as proteins, RNA, and DNA interact each other in a specific combination (multifactor interaction) and form their reaction sites in the nucleus. Thus, the genes transcription is precisely controlled "spatiotemporally". In this workshop, we would like to discuss new findings of the spatiotemporal transcription control by multifactor interaction.

3PW-05

December 3 (Fri) 15：45～18：00

State-of-the-art research in “perivascular cells"

E/J

Organizer: Seiji Yamamoto (University of Toyama), Atsushi Enomoto (Nagoya University)

Pericytes and perivascular fibroblasts have been payed attention in perivascular cell research field; however, the cell lineages and roles in blood vessels are still under debate. In addition, perivascular cells have been suggested to be involved in pathological conditions such as various tumors and intractable neurological diseases; however, the pathogenesis and progression mechanisms at the cellular and molecular levels are still unknown. In this workshop, based on the current evidences from cutting-edge researches, we discuss the significance of perivascular cells.

3PW-06

December 3 (Fri) 15：45～18：00

Strategy for maintaining homeostasis under stressful condition with stress coping mechanism

E/J

Organizer: Naoyuki Kataoka (The University of Tokyo), So Masaki (Ritsumeikan University)

Organisms are constantly exposed to environmental stresses such as low oxygen, low/high temperature or low nutrients. These stresses induce cellular stress responses to maintain homeostasis under the stressful conditions. In addition, cells utilize such stress coping mechanism to regulate their physiological state. On the other hand, failure in stress management often results in diseases. In this workshop, we attempt to comprehensively understand the cellular stress response mechanisms by broadly overviewing the strategies in cells and diseases caused by stresses.

3PW-07

December 3 (Fri) 15：45～18：00

Retrotransposon epigenetics in germ cells and its intergenerational effects

J

Organizer: Keiko Nohara (National Institute for Environmental Studies), Kenji Ichiyanagi (Nagoya University)

A variety of environmental factors, including nutrition, chemicals, and stress, have been suggested to affect the health of offspring by altering the germline epigenome. One of the key roles of germline epigenome is the regulation of retrotransposons. In this session, we will discuss the circumstances that can alter the germline epigenome at retrotransposons. Intergenerational effects of such alteration will also be discussed.

3PW-08

December 3 (Fri) 15：45～18：00

8th Insect meeting: Communication between different research fields via Enotomolgy

J

Organizer: Kakeru Yokoi (NARO), Takeru Nakazato (ROIS)

Insects are the most diverse species in Earth, and they show interesting biological phenomenon. In “Insect meeting", speakers, who were mainly posdoc or Ph. D candidate students, introduced their unique research objectives. Thus, our meeting encouraged discussions between researchers having different backgrounds. In this our meeting, we aim to encourage researcher's discussions between the different research fields and establishing new insights by the lectures related to insect unique phenomenon and revealing their molecular mechanism.

3PW-09

December 3 (Fri) 15：45～18：00

Sociology of intra-/inter-cellular environment: How Dose Life Find “Comfort"?

E/J

Organizer: Kazuo Yamamoto (Nagasaki University), Chiho Watanabe (Hiroshima University)

Organisms on the Earth live in varieties of size and shape. There seem to be rules that promise an optimum according to communications between organisms and their environment. These rules might produce a nice balance beyond multiple scales, i.e., from a body to tissues, cells, organelles, and genetic materials. This workshop aims to explore how life finds its “comfort" from various perspectives.

3PW-10

December 3 (Fri) 15：45～18：00

Regulatory system of plant resilience under fluctuating environment Supported by: Grant-in-Aid for Transformative Research Areas（A）"Plant Resilience under Fluctuating Environment"

J

Organizer: Tomonao Matsushita (Kyoto University), Yoshikatsu Matsubayashi (Nagoya University)

Plants are exposed to constantly fluctuating environments where they sprout. In this workshop, by focusing on molecular mechanisms that regulate such fluctuating temporal and spatial environmental information, and the proteome diversification mechanisms supporting them, we would like to discuss the nature of plant environmental resilience that enables plants to adapt robustly and flexibly to environmental changes across a wide dynamic range.

3PW-11

December 3 (Fri) 15：45～18：00

Morphogenesis by moving cells

E

Organizer: Mikiko Inaki (Osaka University), Daiki Umetsu (Tohoku University)

This workshop highlights the morphogenesis by moving cells. Moving cells can shape tissues with high plasticity. However, due to the high degree of freedom and complexity, their analyses are challenging, and there are no fixed approaches common to different model systems. We discuss on cell migration from a wide range of scales and various perspectives, from the mechanisms inducing cell movement to the mechanisms generating cohesive dynamics of collective cells. We hope this workshop brings cell migration researches in developmental biology to a new phase.

3PW-12

December 3 (Fri) 15：45～18：00

Researches focused on species closely related to classical model organisms reveal molecular mechanisms of evolution and diversity

E/J

Organizer: Yoshihiro Omori (Nagahama Institute of Bioscience and Technology), Satoshi Ansai (Tohoku University)

Recent technologies enable us to investigate how the diversified traits in “non-model" organisms have evolved; however, the molecular basis of such traits remains largely unknown. In this session, researchers who focused on species closely related to classical model organisms to understand the molecular basis for the evolution of morphology, behavior, and reproductive isolation will summarize their recent findings and provide novel insights into this field.

3PW-13

December 3 (Fri) 15：45～18：00

Molecular and cellular networks of inflammaging

J

Organizer: Ichiro Manabe (Chiba University), Yuichi Oike (Kumamoto University)

Inflammaging points to the close association between chronic inflammation and aging. However, the mechanistic understanding of the initiation and propagation of inflammaging and its role in age-associated diseases. For instance, it is not clear as to how inflammation is activated by age-associated factors and mechanistically as to how inflammaging promotes age-associated diseases. In this workshop, we will discuss the mechanistic underpinning of inflammaging.

3PW-14

December 3 (Fri) 15：45～18：00

TOR research in its prime

E

Organizer: Tatsuya Maeda (Hamamatsu University School of Medicine), Takashi Ushimaru (Shizuoka University)

The protein kinase TOR plays the important and fundamental role of integrating growth-related signals and controlling the cellular growth and survival. Naturally, TOR participates in the regulation of a vast range of physiological functions, and its failure underlies a variety of pathological conditions. This workshop aims at overviewing the maturating TOR research field in the 30th anniversary year of the TOR discovery.

3PW-15

December 3 (Fri) 15：45～18：00

Mechanical properties of the extracellular environment for brain development and repair Co-hosted by: SPIRITS of Kyoto University

E

Organizer: Taeko Kobayashi (Kyoto University), Yoichi Kosodo (Korea Brain Research Institute )

Each organ in our bodies has its own particular mechanical properties, determined by the tissue environment consisting of the extracellular matrix and other factors. The brain is especially soft among organs, and its stiffness is altered with aging and disease progression. Recent works have started to reveal the importance of substrate stiffness in regulating several cellular activities, including proliferation and differentiation. On the other hand, significant roles of stiffness in vivo in coordinating tissue homeostasis and functions have rarely been explained so far. In this workshop, we will introduce recent research topics related to brain formation and repair by tissue mechanical factors, followed by fruitful discussions.