The following 6 symposia are scheduled.
Theme 1: Clock / Sleep
Frontiers in Sleep and Hibernation Research
Organizer: Masashi Yanagisawa (University of Tsukuba)
Sleep and hibernation (torpor) represent a highly regulated state of inactivity in animals. Many fundamental questions remain mysterious in the field: “Why is sleep essential in all animals with nervous system?” “How does sleep need accumulate during wakefulness?” “How is hibernation regulated?” “Can we induce a hibernation-like state in non-hibernating species?” “How sleep/wake and hibernation interact with each other?” This symposium introduces some of cutting-edge investigations into these tempting questions.
Theme 2: Development / Reproduction
Synthetic Embryology - Bottom-up approaches to study human & animal development
|Organizers:||Mitinori Saitou (Kyoto University)
Cantas Alev (Kyoto University)
Synthetic embryology is an emerging field of life-science research which utilizes stem cells and avanced bioengineering approaches to reconstruct distinct aspects of developmental biology and embryonic development in vitro. Being able to reconstitute in a bottom-up approach developmental processes in vitro from stem cells opens up new and exciting opportunities for studying and understanding early embryonic development in human and other mammalian species. Such synthetic developmental biology oriented studies range from PSC-based models of pre- and peri-gastrulation development to novel stem cell based models of human and animal organogenesis and tissue formation. Our symposium will bring together leading national and international scientists in the field of synthetic embryology to discuss the latest developments in this exciting new field at the cross roads of developmental biology and stem cell research.
Theme 3: Bioinformatics / Technology / System
Technology, genomics, computational biology approach towards ncRNA functions
Organizer: Piero Carninci（RIKEN Center for Integrative Medical Sciences）
Non-coding RNAs (ncRNAs) play essential role in biological phenomena by folding into complex structures and functioning by interacting with other RNAs, DNA and proteins. However, their functional mechanisms are not broadly studied. In this session, we will discuss the functional mechanisms of ncRNAs with new technologies that allow us to analyze their modification, structures, spatial positioning and interactions.
Theme 4: Aging
Continuity of the Life and Aging
|Organizers:||Takehiko Kobayashi (The University of Tokyo)
Akiko Takahashi (Cancer Institute)
The life of organisms has three stages: development, inheritance and aging. Inheritance is the period of reproduction that supports the continuity of life, while aging attenuates and leads it to termination. In this symposium, the transition will be considered from the latest research on the molecular mechanisms of maintenance of stem cells, and cellular and individual aging.
Biodiversity for Exciting Discoveries
Organizer: Tetsuya Higashiyama (The University of Tokyo/ Nagoya University)
There are a wide variety of species on earth. On the other hand, in advancing molecular biology, we have to rely on a limited number of model organisms. However, recent technological developments related to “ome” analysis and genome editing are breaking down that barrier. Researchers have a great deal of freedom in discovering new mechanisms from biodiversity itself and utilizing unique non-model organisms. At this symposium, we would like to enjoy the unique research of the speakers who are advancing research utilizing biodiversity.
Theme 6: Chromatin / Epigenetics
RNA in Nuclear Architecture and Chromatin Organization
|Organizers:||Hitoshi Kurumizaka (The University of Tokyo)
Yuka Iwasaki (Keio University)
Various features of the nuclear architecture and chromatin organization, including LLPS (liquid-liquid phase separation) formation and chromatin conformation, are essential to regulate nuclear processes, such as gene transcription and expression. In addition to multiprotein-chromatin complexes, RNA has been shown to play a key role within this process. Here, we discuss recent studies that have provided insight into the interplay between nuclear architecture, chromatin organization, and gene expression.