第23回日本蛋白質科学年会

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Program

Timetable
*Tentative Schedule as of April, 2023
Symposium
Young Scientist Award Symposium
Basic Lecture
Workshop
Poster day1
Poster day2
Poster day3
Poster Award Flash talk day1
Poster Award Flash talk day2
Luncheon Seminar

Symposium

Accelerating Protein Design and Engineering　

[Session Language: English]
July 5（Wed）9:15-11:45
Organizers: Yuta Suzuki (Kyoto Univ.), Naohiro Terasaka (Tokyo Institute of Technology)

William F. DeGrado (Univ. of California)
Andrew Ellington (Univ. of Texas at Austin）
Takahiro Kosugi (Institute for Molecular Science）
Yasunori Okamoto (Tohoku Univ.）

If we, scientists, can serve as designers to modify and control the protein functions and structures, we would be able to create higher-order functional proteins comparable to biomolecules or unnatural proteinaceous material beneficial to humankind. This symposium will feature speakers aiming to develop/exploit cutting-edge technologies in protein design and engineering.　

Young Scientist Award Symposium

Young Scientist Award Symposium

[Session Language: English]
July 6 (Thu）9:00-11:30
Chairs: Satoko Akashi (Yokohama City Univ.), Eriko Nango (Tohoku Univ.)

Masatake Sugita (Tokyo Tech)
Seiya Tajima (The Univ. of Tokyo)
Sakura Takada (Keio Univ. )
Hirofumi Kosuge (Univ. of Tokyo)
Masatomo So (Nara Med. Univ. )
Hotaka Kobayashi (The Univ. of Tokyo)
Kichitaro Nakajima (Osaka Univ. )
Tatsuki Tanaka (The Univ. of Tokyo)
Shingo Kanemura (Kwansei Gakuin Univ. )
Tomoki Himiyama (AIST)

Basic Lecture　

Basic course on production and structural-functional analysis of target proteins

[Session Language: Japanese]
July 6 (Thu）9:00-11:10
Organizers: Takeshi Murata (Chiba Univ.), Yoshitake Maeda (Axil Capital Advisors, KK)

Takeshi Murata（Chiba Univ.）
Satoru Nagatoishi（The Univ. of Tokyo）
Kenji Iwasaki（Univ.of Tsukuba）
Mitsunori Ikeguchi（Yokohama City Univ.）

In this session, experts in the field will give an easy-to-understand overview of the basics and current status of (1) production of target proteins, (2) physicochemical analysis using purified samples, (3) 3D structural analysis using purified samples, and (4) computer analysis using obtained structural information, which are important for protein science research.

WORKSHOPS

Day１ July 5（Wed）

WS1　　9:15-11:45　

[Session Language: Japanese]

Molecular mechanism of chromatin modifications: structural analysis, development of modified nucleosome and drug discovery

Organizers: Kyohei Arita (Yokohama City Univ.), Tsuyoshi Konuma (Yokohama City Univ.)

Amika Kikuchi (Yokohama City Univ.)
Tsuyoshi Konuma (Yokohama City Univ.)
Takashi Umehara (RIKEN)
Gosuke Hayashi (Nagoya Univ.)
Takayoshi Suzuki (Osaka Univ.)
Minoru Yoshida (RIKEN)

Chromatin modifications (DNA methylation and histone modifications) are important biological phenomena that regulate gene expression, and their disruption causes serious diseases including cancer and inflammation. In this workshop, we will introduce latest structural biology research to elucidate the basic principles of chromatin modifications, the development of sample preparation techniques, and the current status of of inhibitor development and future prospects in this research field.

WS2　　9:15-11:45

[Session Language: Japanese]

Transformative Research Areas (B): Chronoproteinology

Organizers: Hikari Yoshitane (Tokyo Metropolitan Institute of Medical Science), Atsushi Mukaiyama (Institute for Molecular Science)

Hikari Yoshitane (Tokyo Metropolitan Institute of Medical Science)
Tomoaki Muranaka (Nagoya Univ.)
Koji Ode (The Univ. of Tokyo)
Atsushi Mukaiyama (Institute for Molecular Science)
Hirofumi Toda (Univ. of Tsukuba)
Kazuhiro Yagita (Kyoto Prefectural University of Medicine)
Takuya Matsuo (Nagoya Univ.)

There are different time scales in biology such as seasonal responses, circadian rhythms, and heartbeats. What is the mechanism that measures or drives “time”? This symposium is co-organized with Transformative Research Areas (B) “Chronoproteinology”. “Time” could be generated by protein dynamics such as protein-protein interactions, post-translational modifications, enzymatic activities, and conformational changes.

WS3　　9:15-11:45　　

[Session Language: Japanese]

Unraveling the kinetics-driven LLPS control

Organizers: Tomohide Saio (Tokushima Univ.), Masaki Okumura (Tohoku Univ.)

Tomohide Saio (Tokushima Univ.)
Shunsuke Shimobayashi (Kyoto Univ.)
Eiichiro Mori (Nara Medical Univ.)
Takuya Yoshizawa (Ritsumeikan Univ./Chugai Pharmaceutical Co., Ltd. )
Masaki Okumura (Tohoku Univ.)
Ayako Furukawa (Yokohama City Univ.)

Despite the accumulating knowledge of LLPS controls in the biological events such as autophagy and stress granule formation, the mechanisms of the kinetic-driven processes are poorly understood. This workshop gathers the top young scientists investigating kinetic aspects of molecules, proteins, organelles, and cells to cultivate the cross-disciplinary discussion and future innovation.

WS4　　16:00-18:30　

[Session Language: Japanese]

Japan Antibody Society - Protein Science Society of Japan Joint Symposium
- Science and Engineering of antibodies and next Gen antibodies as a protein -

Organizers: Susumu Uchiyama (Osaka Univ.), Yuji Ito (Kagoshima Univ.)

Saeko Yanaka (Kushu Univ.)
Yuji Ito (Kagoshima Univ.)
Tomofumi Kurokawa (Taisho Pharmaceutical Co. Ltd.)
Hitoshi Katada (Chugai Pharmabody Research Pte. Ltd.)
Susumu Uchiyama (Osaka Univ.)

Therapeutic antibodies have been successful recent 25 years and now next generation antibody related modalities are under development.In this joint-workshop with the Antibody Society of Japan which was lauched in 2022,basic science and recent advancement in the industrial field about antibody and next generation antibody wil be introduced and discussed mainly from the protein science aspect.

WS5　　16:00-18:30　

[Session Language: Japanese]

Cytoplasmic zoning: understanding the diverse reaction fields created by membranes and phase separation

Organizers: Nobuo Noda (Hokkaido Univ.), Yuko Fukata (National Inst for Physiological Sciences)

Masaaki Komatsu (Juntendo Univ.)
Tamako Nishimura (Nara Institute of Science and Technology)
Junichi Ikenouchi (Kyushu Univ.)
Keiko Kono (Okinawa Inst. of Sci. and Tech. Grad. Univ.)
Shunsuke Shimobayashi (Kyoto Univ.)
Hitoshi Nakatogawa (Tokyo Tech.)

The cytoplasm of eukaryotic cells is divided into various zones by lipid membranes and liquid-liquid phase separation, which allow various biochemical reactions to be carried out efficiently and without confusion. In this workshop, we will introduce the diverse and sophisticated cellular functions of “cytoplasmic zoning”, which have been overlooked so far.

WS6　　16:00-18:30

[Session Language: Japanese]

Metal homeostasis – Mechanisms regulating physiological phenomena through bio-metals in vivo

Organizers: Yoshiaki Furukawa (Keio Univ.), Hitomi Sawai (Nagasaki Univ.)

Michio Suzuki (The Univ. of Tokyo)
Tasuku Hirayama (Gifu Pharm. Univ.)
Hitomi Sawai (Nagasaki Univ.)
Junpei Takano (Osaka Metropolitan Univ.)
Taiho Kambe (Kyoto Univ.)
Yoshiaki Furukawa (Keio Univ.)
Yasuo Uchida (Tohoku Univ.)

Various physiological processes are realized in living organisms by homeostatic control of bio-metals with a complex intracellular network of proteins. In this session, we will introduce our research on the regulation of “metal homeostasis” with a view to disease prevention, food crisis, and environmental issues.

WS7　　16:00-18:30　　

[Session Language: Japanese]

We got these amazing new findings by being picky about the methodology of cryo-electron microscopy!

Organizers: Toshio Moriya (High Energy Accelerator Research Organization), Takeshi Yokoyama (Tohoku Univ.)

Toshio Moriya (High Energy Accelerator Research Organization)
Hiroshi Ouchiyama (Intel K.K.)
Daisuke Miyamoto (Amazon Web Services Japan G.K.)
Atsushi Tsugita (Tohoku Univ.), Atsuki Nakano (Kyoto Sangyo Univ.)
Moe Ishikawa (Kyoto Univ.)

In structural analysis, the usage of cryo-EM has become common in Japan over the past few years. With cryo-EM, being picky about the methodology often leads to breakthroughs, such as new findings through higher resolution and dynamics analysis, and more comprehensive structural analysis through the sophistication of hardware and software. Here, presenters will share the “ingenuity” that led to the success of their structural analysis.

WS8　　16:00-18:30　

[Session Language: Japanese]

New Era of Integrated Structural Biology with NMR Platform

Organizers: Takanori Kigawa (RIKEN), Chojiro Kojima (Yokohama National Univ.)

Kenji Iwasaki (Univ. of Tsukuba)
Midori Kamimura (CBI Research Inst.)
Takanori Kigawa (RIKEN)
Genji Kurisu (Osaka Univ.)
Motomasa Tanaka (RIKEN)
Hidekazu Hiroaki (Nagoya Univ.)

Recent technological innovations such as AlphaFold2 and CryoEM have drastically changed the world of structural biology. In this workshop, the current status and challenges in integrated structural biology using NMR are summarized by leading researchers, and the role of NMR in the new era will be discussed.

Day2 　July 6 (Thu）

WS9　　9:00-11:30　

[Session Language: Japanese]

Post-lysosome: a new wave from the site of degradation

Organizers: Taki Nishimura (The Univ. of Tokyo), Harunori Yoshikawa (Tokushima Univ.)

Naonobu Fujita (Tokyo Tech.)
Monami Ogura (Osaka Univ.)
Tomoko Kawamata-Horie (Tokyo Tech.)
Harunori Yoshikawa (Tokushima Univ.)
Koshi Imami (RIKEN)
Kotaro Tsuboyama (The Univ. of Tokyo)
Taki Nishimura (The Univ. of Tokyo)

Accumulating evidence shows that lysosome serves as a signaling hub for the regulation of lifespan and aging by supplying degraded products and recruiting key signaling molecules. “Post-lysosome” expresses such a cellular event on lysosomes and/or after lysosomal degradation. In this workshop, we will introduce recent studies on post-lysosome and cutting-edge technologies essential for the research on post-lysosome.

WS10　　16:00-18:30　　　　

[Session Language: Japanese]

Protein engineering technologies to unearth the life in the sequences

Organizers: Tatsuya Sawasaki (Ehime Univ.), Sohei Ito (Univ. of Shizuoka)

Sohei Ito (Univ. of Shizuoka)
Shogo Nakano (Univ. of Shizuoka / PREST, JST)
Hafumi Nishi (Tohoku Univ.)
Tatsuya Sawasaki (Ehime Univ.)
Yuusuke Hagiwara (Ajinomoto Co., Inc.)
Yasuhisa Asano (Toyama Pref. Univ.)

Life has adapted to its environment by changing the sequence of proteins to create highly regulated living systems such as those found in humans. The 3.5 billion years of life have been passed down to us in the form of sequence information. Today, with the development of genome sequencing technology and bioinformatics, we have access to a great amount of sequence information. In this workshop, we will introduce our research on engineering technology to design proteins based on the memory of life and information sleeping in the genome sequences.

WS11　　16:00-18:30　　　　

[Session Language: Japanese]

Multifaceted protein functionality in biological system of megadalton complexity

Organizers: Shinobu Chiba (Kyoto Sangyo Univ.), Kayo Nozawa (Tokyo Tech.)

Shinobu Chiba (Kyoto Sangyo Univ.)
Yuhei Chadani (Tokyo Tech.)
Toshiya Endo (Kyoto Sangyo Univ.)
Yutetsu Kuruma (Japan Agency for Marine-Earth Science and Technology)
Haruhiko Ehara (RIKEN)
Tomoya Tsukazaki (Nara Institute of Science and Technology)

As the understanding of biomolecules advanced rapidly, the traditional view of protein functions became multifaceted. To further understand the life systems, we need to study molecular systems of megadalton-sized protein complexes present in the cell. In this joint workshop of “Grant-in-Aid for Transformative Research Areas” teams, we will introduce attempts to analyze the esoteric life systems by fusing cutting-edge technologies of protein science, structural biology, and artificial cell research.

WS12　　16:00-18:30　　　　

[Session Language: Japanese]

Understanding and controlling proteins through the eyes of reaction chemistry

Organizers: Kounosuke Oisaki (National Institute of Advanced Industrial Science and Technology), Kenzo Yamatsugu (The Univ. of Tokyo)

Junko Ohkanda (Shinshu Univ.)
Kounosuke Oisaki (National Institute of Advanced Industrial Science and Technology)
Yuichiro Hori (Kyushu Univ.)
Kenzo Yamatsugu (The Univ. of Tokyo)
Tadahiro Shimazu (RIKEN)

Proteins are responsible for the majority of functions found in living systems and nature. Reaction chemistry-based technologies can provide new perspectives on the analysis and regulation of dynamic functions and intervention in living systems. In this workshop, we will invite lecturers who are engaged in advanced researches on protein science from such viewpoints.

WS13　　16:00-18:30　　　　　　　　

[Session Language: English]

Cross-Scale Measurement Technology for Revealing New Biological Phenomena in Cells

Organizers: Kenji Inaba (Tohoku Univ.), Noritaka Nishida (Chiba Univ.)

Noritaka Nishida (Chiba Univ.)
Kenji Inaba (Tohoku Univ.)
Mutsuko Kukimoto (RIKEN)
Richard Wong (Kanazawa Univ.)
Hideji Murakoshi (NIPS)
Yusuke Hirabayashi (The Univ. of Tokyo)

In the cell, a wide variety of proteins exist in spaces separated by cell membranes and organelles, and their dynamic changes in conformations and localization in response to changes in the intracellular environment and signal transduction enable various cellular functions to be performed. Therefore, in order to reveal biological phenomena occurring in cells, it is necessary to develop measurement techniques that enable cross-scale visualization of proteins from their atomic-level structures to spatiotemporal dynamics at the molecular and cellular levels. In this workshop, researchers who are developing and applying various in-cell measurement techniques will present their latest topics of research and discuss new biological phenomena that have been revealed by their studies.

WS14　　16:00-18:30　　　　　　　　

[Session Language: Japanese]

Molecular movies of proteins: Toward concerted collaboration between experiments and theories

Organizers: Yuji Furutani (Nagoya Inst. Tech.), Kiyoshi Yagi (RIKEN)

Kiyoshi Yagi (RIKEN)
Osamu Miyashita (RIKEN)
Ai Niitsu (RIKEN)
Misao Mizuno (Osaka Univ.)
Ayori Mitsutake (Meiji Univ.)
Yuji Furutani (Nagoya Inst. Tech.)

Molecular mechanisms of protein should be understood based on not only its static structure, but also the dynamic atomic structures in action. Nowadays, time-resolved X-ray crystallography and cryo-electron microscopy have been developed remarkably. Moreover, studies of chemical reactions in protein require precise molecular information obtained by various kinds of spectroscopic and theoretical methods including quantum chemistry. In this workshop, we discuss how proteins work, from both aspects of experiments and theories.

Day3 　July 7（Fri）

WS15　　8:30-11:00　　　　　　　

[Session Language: Japanese]

Broad overview of amyloid research from academia to drug discovery

Organizers: Hisashi Okumura (Exploratory Research Center on Life and Living Systems), Koki Makabe (Yamagata Univ.)

Satoru G. Itoh (Inst. for Molecular Science)
Teiji Kimura (R&D Office)
Koki Makabe (Yamagata Univ.)
Naoyuki Miyashita (Kindai Univ.)
Maho Yagi-Utsumi (Nagoya City Univ.)

Amyloid fibrils cause more than 40 neurodegenerative diseases. Although amyloid has often been treated as a causative agent of a disease, it has recently been recognized as an amyloid catalyst, a physiologically active entity. The recent emergence of therapeutic agents for Alzheimer’s disease and other neurodegenerative disorders has attracted public attention. In this workshop, we will invite researchers from academia and industry who are actively working in amyloid research to introduce their recent research results and to look ahead to future research.

WS16　　8:30-11:00　　　　　　　　　

[Session Language: English]

Uncover the functional mechanisms of supramolecular assemblies by observation

Organizers: Takahiro Kosugi (Inst. for Molecular Science), Takeshi Yokoyama (Tohoku Univ.)

Kenichi Umeda (Kanazawa Univ.)
Akihiro Kawamoto (Osaka Univ.)
Hotaka Kobayashi (JST PRESTO / The Univ. of Tokyo)
Ryo Nishihara (National Institute of Advanced Industrial Science and Technology)
Kayo Hibino (National Institute of Genetics)
Takeshi Yokoyama (Tohoku Univ.)

Proteins and other biomacromolecules form dynamic supramolecular assembles in cells, and that these play important roles in biological activities. In this workshop, we will invite talented early-career researchers who observe the structures and dynamics of various supramolecular assembles by their own cutting-edge techniques and try to uncover the functional mechanisms. We hope this workshop provides an opportunity to develop new research field of the dynamic supramolecular assembles from the viewpoint of protein science.

WS17　　8:30-11:00　　　　　　　

[Session Language: Japanese]

Frontiers of research of beta-barrel proteins

Organizers: Takuya Shiota (Univ. of Miyazaki), Hironori Takeda (NAIST)

Yu Imai (Shinshu Univ.)
Kenichiro Imai (AIST)
Kaori Chiba (National Institute of Technology, Ibaraki Coll.)
Takuya Shiota (Univ. of Miyazaki)
Hironori Takeda (NAIST)

Unique fold protein, beta-barrel acts essential roles for cell viability at the outer membranes of bacteria, mitochondria, and chromoplast and as soluble proteins, fluorescent proteins, like a GFP, are used as basic tools for imaging. In this workshop, we will invite pioneers and discuss the beta-barrel proteins from multiple aspects.

WS18　　15:40-18:10　　　　　　

[Session Language: Japanese]

Integrated understanding of protein self-condensation process from the viewpoint of dynamic solution environments

Organizers: Naotaka Sekiyama (Kyoto Univ.), Kenji Sugase (Kyoto Univ.)

Naotaka Sekiyama (Kyoto Univ.)
Kenji Sugase (Kyoto Univ.)
Hideki Nakamura (Kyoto Univ.)
Norio Yoshida (Nagoya Univ.)
Hiromi Imamura (Kyoto Univ.)
Kyoko Matsuzaki Tokyo Med. Dent. Univ.（from April: Kyorin Univ.)

Spatio-temporal changes in the solution environment regulate self-condensation of intrinsically disordered proteins such as liquid-liquid phase separation and amyloid fibrillation, which are associated with neurodegenerative diseases. We aim to comprehensively understand the events from the microscopic insights revealed by atomic- and molecular-level analysis to the macroscopic perspectives revealed by cellular- and organism-level experiments.

WS19　　15:40-18:10　　　

[Session Language: Japanese]

New stage of development　in Structural Biology of Membrane Protein Complexes to Accelerate Life Science Research

Organizers: Ryoji Suno (Kansai Medical Univ.), Tomoya Hino (Tottori Univ.)

Kazuhiro Abe (Nagoya Univ.)
Dohyun Im (Kyoto Univ.)
Atsuhiro Shimada (Gifu Univ.)
Naotaka Tsutsumi (Okayama Univ.)
Norie Hamaguchi (Chiba Univ.)
Yongchan Lee (Yokohama City Univ.)

In recent years, with the advancement of cryo-EM single-particle analysis techniques in addition to X-ray crystallography, structural biology, especially membrane protein structural analysis research, has been remarkably accelerated. There have been a series of exciting reports on the elucidation of dynamic molecular mechanisms of proteins by structure determination in various reaction states and on the successful high-resolution structure determination of supramolecular complexes, which had been difficult to achieve. Therefore, in this workshop, we will report and discuss the latest membrane protein structural studies and discuss the possibilities for further development of life science research in the future.