ベストプレゼンテーション賞

2019年

Category-1: Hematopoiesis and Immune Environment
1-H-W6-19-O/P
Accumulation of leukemic cells to the spleen is regulated by a transcription factor Tlx1 expressed in perifollicular mesenchymal cells
Yusuke Amemiya (Tokyo University of Science)

Category-2: B cells
2-F-W10-19-O/P
Requirement for memory B cell activation in protection from heterologous influenza virus reinfection
Sarah G Leach (Osaka University)

Category-3: T cells
1-C-W1-16-O/P
The influenza virus replication derived broad protective antibody response
Kosuke Miyauchi (RIKEN)
2-C-W8-6-O/P
A role of extracelluar vesicles in T cell development
Tomoyoshi Yamano (Kanazawa University)

Category-4: Innate lymphocytes
3-E-W19-5-O/P
The role of group 2 innate lymphoid cells(ILC2) in pulmonary fibrosis
Natsuko Otaki (Keio University)

Category-5: Dendritic cells, macrophages, granulocytes
3-F-W20-3-O/P
Novel DC targeting by allogenic T-cells for multifocal prophylactic antibody production
Hisashi Ueta (Dokkyo Medical University)
3-F-W21-6-O/P
A chemokine signal amplifier FROUNT regulates tumor cell-mediated macrophage activation and migration to tumor sites
Etsuko Toda (Nippon Medical School)

Category-6: Allergy
3-D-W17-12-O/P
Clec10a regulates mite-induced dermatitis
Kazumasa Kanemaru (University of Tsukuba)
3-D-W18-38-O/P
Targeted deletion of TSLP receptor reveals cellular mechanisms underlying acute versus chronic type 2 inflammation
Hiroki Kabata (Keio University)

Category-7: Cytokines and chemokines
1-D-W2-15-O/P
The mechanism for regulation of type 2 cytokine production from ILC2 by Tristetraprolin.
Yuki Hikichi (RIKEN)

Category-8: Tolerance and Immune suppression
1-E-W3-3-O/P
DNAM-1 suppresses Foxp3 stability of regulatory T cells in a TIGIT dependent manner
Kazuki Sato (University of Tsukuba)

Category-9: Virus infectionBacterial / mycofungal / parasite infection
3-C-W15-5-O/P
Circulating extracellular vesicle miR-451a, but not human papilloma virus vaccine, plays a crucial role in an autoimmune disorder
Kana Ishikawa (Kumamoto University)
3-C-W16-3-O/P
Critical role of Irgm2 in host defense mechanism against Toxoplasma gondii
Ariel Pradipta (Osaka University)

Category-10: Innate immunity
1-G-W5-19-O/P
Unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
Takashi Mino (Kyoto University)
2-E-W9-6-O/P
Lamtor1/p18 is required for activation of inflammasome
Kohei Tsujimoto (Osaka University)

Category-11: Mucosal-Skin Immunity
2-G-W11-15-O/P
Intestinal Prevotella copri isolated from rheumatoid arthritis patients exacerbates murine models of arthritis
Hiroshi Ueki (Univ. of Tokyo)
3-G-W22-1-O/P
The impact of fasting on immune cell dynamics and mucosal immune response
Motoyoshi Nagai (Keio University)
3-G-W23-13-O/P
Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development
Sonoko Takahashi (RIKEN)

Category-12: Autoimmune diseases
2-B-W7-1-O/P
Human TLR7 deficiency results in autoimmune conditions
Natsuko Yamakawa (National Institutes of Biomedical Innovation, Health and Nutrition)
3-B-W13-21-O/P
Inflammasome drives release of mitochondrial DNA enclosed in extracellular membrane vesicles and propagation of inflammation in Bechet disease
Hachiro Konaka (Osaka University)
3-B-W14-2-O/P
Survival of peripherally derived monocytes in the CNS is crucial for EAE relapse
Nobuhiko Takahashi (Hokkaido University)

Category-13: Tumor immunity
2-H-W12-1-O/P
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
Shohei Koyama (Osaka University)
3-H-W24-7-O/P
An inhibitory immunoreceptor CD300a suppresses tumor infiltrating Treg cells and tumor development through binding to phosphatidylserine on tumor-derived exosomes
CYuta Nakazawa (University of Tsukuba)
3-H-W25-17-O/P
Antibody-mediated transient depletion of CD4⁺ cells enhances the remodeling of the T-cell receptor repertoire and promotes anti-tumor immune responses in cancer patients
Hiroyasu Aoki (Tokyo University of Science)

Category-14: Human Immunology (Immunointervention)
1-F-W4-6-O/P
Creation of HLA class I and class II Tg NOD/SCID/Il2rgKO (NSG) mice for studying interaction between human immunity and leukemia
Ari Itoh-Nakadai (RIKEN)

2018年

Category-1: Hematopoiesis and Immune Environment
1-C-WS3-13-O/P
CD150^high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine
Yuichi Hirata (Columbia Univ.)
1-C-WS4-3-O/P
Characterization of thymic fibroblast subsets
Masanori Tsutsumi (The Univ. of Tokyo)

Category-2: B cells
1-D-WS5-10-O/P
Metabolic control of germinal center B cell and plasma cell differentiation
Kei Haniuda (Tokyo Univ. of Science)
1-D-WS6-4-O/P
Characteristics of naïve B cells in murine IgA Nephropathy
Yoshihito Nihei (Juntendo Univ.)

Category-3: T cells
2-A-WS14-4-O/P
Roles of Rap1, Talin-1 and Kindlin-3 in lymphocyte homing to peripheral and mucosal lymph nodes
Yuji Kamioka (Kansai Medical Univ.)
3-A-WS23-14-O/P
Low-affinity TCR engagement induces Itm2a to mediate T cell maintenance in the periphery
Moe Shiokawa (Osaka Univ.)

Category-4: Helper T cells
1-H-WS13-4-O/P
Host defense against oral bacteria by bone-damaging T cells
Masayuki Tsukasaki (The Univ. of Tokyo)
1-H-WS13-15-O/P
Cholesterol 25-hydroxylase expressing CD4⁺ T cell regulates tissue inflammation
Hayato Takahashi (Keio Univ.)

Category-5: Innate lymphocytes
1-B-WS1-5-O/P
β2 adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses
Saya Moriyama (Cornell Univ.)
1-B-WS2-8-O/P
MAIT cells as a new therapeutic target for systemic lupus erythematosus.
Asako Chiba (Juntendo Univ.)

Category-6: Dendritic cells and macrophages
1-E-WS8-3-O/P
A chemokine signal amplifier FROUNT promotes tumor progression by facilitating migration and activation of tumor-associated macrophage
Etsuko Toda (Tokyo Univ. of Science)
1-E-WS7-5-O/P
LPS from lymphoid-tissue resident Alcaligenes induces IgA without excessive inflammation via its weak TLR4 agonist activity.
Naoko Shibata (Waseda Univ.)

Category-7: Mast cells & granulocytes
2-H-WS21-1-O/P
Phosphatidylserine exposure self-regulates mast cells’ degranulation
Yaqiu Wang (Univ. of Tsukuba)
2-H-WS21-6-O/P
Histamine released from skin-infiltrating basophils but not mast cells is crucial for acquired tick resistance in mice
Soichiro Yoshikawa (Tokyo medical and dental Univ. (TMDU))

Category-8: Allergy
2-G-WS20-7-O/P
Identification and functional analyses of three dendritic cell subsets accumulating in skin-draining lymph nodes upon the expression of thymic stromal lymphopoiein in the skin
Miyuki Omori-Miyake (Tokyo Women’s Medical Univ.)
2-G-WS20-8-O/P
Local skin memory response is mediated by tissue resident memory T cells
Akihiko Murata (Tottori Univ.)

Category-9: Cytokines and chemokines
1-G-WS11-16-O/P
Chronic interferon-gamma signals impair memory CD8 T cell maintenance
Ruka Setoguchi (RIKEN)
1-G-WS12-3-O/P
A division of labour for the type ?interferon and apoptosis induction after viral infection
Tomohiko Okazaki (The Univ. of Tokyo)

Category-10: Tolerance and Immune suppression
2-C-WS16-13-O/P
Transcription factor JunB is essential for effector regulatory T cell homeostasis and function
Shin-ichi Koizumi (Okinawa Institute of Science and Technology Graduate Univ.)
3-C-WS27-2-O/P
A novel mechanism for induction of tissue-specific immune evasion
Tetsuya Sakurai (Kyushu Univ.)

Category-11: Virus infection
2-B-WS15-7-O/P
In vivo imaging of the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung
Hiroshi Ueki (Univ. of Tokyo)
2-B-WS15-19-O/P
Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis
Ryota Sato (The Univ. of Tokyo)

Category-12: Bacterial / mycofungal / parasite infection
3-H-WS36-1-O/P
Porphyromonas gingivalis negatively regulates host immune responses through inhibitory receptor, Siglec
Yasunobu Miyake (Saga Univ.)
3-H-WS36-17-O/P
Analysis of novel Shigella effector mechanism that regulate host cell death
Hiroshi Ashida (Tokyo Medical and Dental Univ.)

Category-13: Endogeneous innate immunity and inflammation
3-D-WS28-12-O/P
Ribonuclease T2 negatively regulates response of the dsRNA sensor TLR3
Kaiwen Liu (The Univ. of Tokyo)
3-D-WS29-8-O/P
Recognition of phospholipids on dead cells via inhibitory C-type lectin receptor
Chihiro Motozono (Osaka Univ.)

Category-14: Mucosal-Skin Immunity
3-F-WS33-5-O/P
Induction of IFNγ-producing CD8 T cells by human derived-commensal bacteria
Takeshi Tanoue (Keio Univ. School of Medicine)
3-F-WS33-4-O/P
Gut microbial metabolite acetate tunes IgA reactivity toward commensal microbes to maintain mucosal homeostasis
Tadashi Takeuchi (RIKEN)

Category-15: Tissue-specific immune diseases
3-B-WS24-7-O/P
Significant associations of human SIGLEC10 polymorphisms with susceptibility to Guillain-Barré syndrome
Xuexin Li (Tokyo Medical and Dental Univ.)
3-B-WS24-10-O/P
TSHR-stimulating autoantibody production by TSHR / MHC class II complexes
Hui Jin (Osaka Univ.)

Category-16: Systemic autoimmune diseases
1-F-WS9-1-O/P
Immune cell-type specific multi-omics analysis revealed contribution of mitochondria in Bcells to systemic lupus erythematosus.
Yusuke Takeshima (The Univ. of Tokyo)
1-F-WS10-5-O/P
The Immunogenetics of Inflammatory Mechanisms by Fibroblast-like Synoviocytes form Rheumatoid Arthritis Patients
Haruka Tsuchiya (The Univ. of Tokyo)

Category-17: Tumor immunity
3-G-WS34-4-O/P
Tumor suppressors of the DAPK family regulate anti-tumor innate immunity through the STING-type I Interferon pathway
Mariko Takahashi (La Jolla Institute for Allergy and Immunology)
3-G-WS35-14-O/P
Distinct transcriptional regulation in tumor-infiltrating regulatory T cells
Yujiro Kidani (Osaka Univ.)

Category-18: Cancer immunotherapy
3-E-WS30-1-O/P
Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment
Hirotake Tsukamoto (Kumamoto Univ.)
3-E-WS31-6-O/P
Use of FLIPr as an antigen delivery vector for cancer immunotherapy
Hsin-Wei Chen (National Health Research Institutes)

Category-19: Human Immunology (Immunointervention)
3-H-WS37-5-O/P
Identification of POGLUT1 as the effector gene in human primary biliary cholangitis (PBC) susceptibility locus chromosome 3q13.33
Yuki Hitomi (The Univ. of Tokyo)
3-H-WS37-22-O/P
Human NK cell development in hIL-7 and hIL-15 knock-in NOD/SCID/IL2rgKO mice
Masashi Matsuda (RIKEN)

2017年

Category-1: Hematopoiesis and Immune Environment
1-G-W13-9-O/P
Crucial role of CD74 in hematopoietic cell differentiation
Tatsuya Shishido (Osaka University)
1-G-W13-10-O/P
Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms
Masashi Kanayama (Duke University School of Medicine)

Category-2: B cells
3-E-W34-2-O/P
FcγRIIb plays an important role in maintaining clonal ignorance and prevents pemphigus phenotype in pathogenic anti-desmoglein 3 antibody knock-in mice
Hisashi Nomura (Keio University School of Medicine)
3-E-W35-3-O/P
Germinal center B cell development by glycolysis and mitochondrial metabolism
Kei Haniuda (Tokyo University of Science)

Category-3: T cells
3-I-W42-4-O/P
Control of proinflammatory γδT cell development by linage-specific TCR signaling pathway
Ryunosuke Muro (The University of Tokyo)
3-I-W43-15-O/P
Systemic metabolic shift induced by PD-1 deficiency perturbs brain monoamines and emotional behaviour
Michio Miyajima (RIKEN Yokohama Institute)

Category-4: Helper T cells
1-I-W18-8-O/P
The transcriptional repressor Bach2 regulates differentiation of pathogenic Th2 cells
Makoto Kuwahara (Ehime University)
1-I-W18-10-O/P
IL-10-Producing Tr2 cells Induced by mTOR/CEBPβ Signaling Regulate Hyphal C. albicans Kidney Infection
Masaki Tajima (NIAID, NIH)

Category-5: Innate lymphocytes
3-B-W28-11-O/P
Role of mucosal-associated invariant T cells in lupus pathogenesis
Goh Murayama (Juntendo University School of Medicine)
3-B-W29-9-O/P
Innate and adaptive immune cells regulate Paneth cell granule formation and α-defensin secretion
Mariko Kamioka (The University of Tokyo)

Category-6: Dendritic cells and macrophages
3-C-W30-11-O/P
Early FcRγ-Erk signaling determines cytokine profile of dendritic cells through C-type lectin receptors
Miyuki Watanabe (Osaka University)
3-C-W31-7-O/P
The novel ubiquitin ligase complex, NQO1-PDLIM2 inhibits TLR-dependent production of selective cytokines by degrading IκB-ζ
Akihiro Kimura (Research Institute National Center for Global Health and Medicine)

Category-7: Mast cells & granulocytes
3-H-W40-21-O/P
STAP-2 is an adopter molecule to positively regulate basophil activation
Jun-ichi Kashiwakura (Hokkaido University)
3-H-W40-27-O/P
Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells (DCs)
Kensuke Miyake (Tokyo Medical and Dental University (TMDU))

Category-8: Allergy
1-A-W1-4-O/P
Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation
Koji Hayashizaki (Chiba University)
2-G-W23-1-O/P
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
Kazuhiko Yamamura (Kyushu University)

Category-9: Cytokines and chemokines
1-H-W15-9-O/P
RNA Splicing Mediator 1 (RSM1) regulates inflammation via alternative splicing of DNA methyltransferase Dnmt3b
Hironao Suzuki (Hokkaido University)
1-H-W16-4-O/P
Function of BMP2 and BMP7 produced by ILC2 in the adipose tissue
Yurina Miyajima (RIKEN IMS)

Category-10: Tolerance and Immune suppression
3-A-W26-2-O/P
Single-cell analysis of autoreactive T cells under the control of PD-1
Hikari Okamura (Tokushima University)
3-A-W26-10-O/P
Antigen-specific immune regulation mediated by TCR-like antibodies
Kazuki Kishida (Osaka University)

Category-11: Virus infection
1-D-W7-8-O/P
Induction of cell death by imiquimod (R837) and its role in immune responses
Haruna Okude (Nara Institute of Science and Technology)
1-D-W8-7-O/P
Identification of a novel HIV-1 restriction factor which selectively degrades viral transcripts.
Daichi Yamasoba (Kyoto University)

Category-12: Bacterial / mycofungal / parasite infection
1-E-W10-12-O/P
Dendritic cell-based vaccination induces lung resident memory Th17 cells that ameliorate pulmonary infection with highly virulent Cryptococcus gattii
Keigo Ueno (National Institute of Infectious Diseases)
1-E-W9-2-O/P
Glycolipids in group A Streptococcus are recognized by Mincle to trigger host immune responses
Imai Takashi (Kyushu University)

Category-13: Endogenous innate immunity and inflammation
1-B-W3-8-O/P
Intracellular metabolite, β-glucosylceramide, is an endogenous adjuvant acting through Mincle
Masahiro Nagata (Osaka University)
1-B-W4-8-O/P
Mechanisms for the regulation of adipose tissue expansion and remodeling by group 2 innate lymphoid cells
Kafi N. Ealey (RIKEN IMS)

Category-14: Mucosal-Skin Immunity
2-A-W19-3-O/P
Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.
Daisuke Takahashi (Keio University Faculty of Pharmacy)
2-A-W19-8-O/P
17,18-EpETE, a metabolite of omega-3 essential fatty acids, inhibited neutrophil mobility and ameliorated skin inflammation in DNFB-induced contact hypersensitivity model
Takahiro Nagatake (National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN))

Category-15: Tissue-specific immune diseases
3-H-W41-13-O/P
Mesenchymal-myeloid cell interactions in renal microenvironment for pathological fibrogenic machinery in kidney fibrosis
Yosuke Kurashima (The University of Tokyo)
1-C-W5-1-O/P
Eomes-positive cytotoxic T helper cells: a new pathogenic immune cell subset in secondary progressive multiple sclerosis?
Ben Raveney (NCNP)

Category-16: Systemic autoimmune diseases
3-G-W38-1-O/P
IFN-γ-T-bet mediated metabolic reprograming in T　helper 1 cellsand its relevance to pathogenesis of SLE
Shigeru Iwata (University of Occupational & Environmental Health)
3-G-W38-3-O/P
Comprehensive analysis of genome and transcriptome analysis of immune cell subsets in peripheral blood mononuclear cells (PBMCs) revealed mitochondria contribution in B cells to systemic lupus erythematosus.
Yusuke Takeshima (The University of Tokyo)

Category-17: Tumor immunity
3-D-W32-11-O/P
Basic leucine zipper transcription factor ATF-like 2 exhibits an anti-tumor effect through upregulation of IL-12 p40 expression
Hisashi Kanemaru (Osaka University)
3-D-W33-1-O/P
The role of soluble CD155 in tumor immune response and metastasis
Okumura Genki (University of Tsukuba)

Category-18: Cancer immunotherapy
1-F-W11-11-O/P
Low-dose HMGN1 synergistically enhances anti-tumor immunity in CD4 depleting antibody-treated mice
Chang-Yu Chen (The University of Tokyo)
1-F-W12-10-O/P
Dying but not dead cancer cells exert the effect of cell-based cancer vaccine
Yoshino Tanaka (Hokkaido University)

Category-19: Human Immunology (Immunointervention)
1-I-W17-1-O/P
Identification of the disease causal variants in human primary biliary cholangitis (PBC) susceptibility gene loci NFKB1/MANBA
Yuki Hitomi (The University of Tokyo)

2016年

Category-1: Hematopoiesis and Immune Environment
3-E-W30-2-O/P
Local function of the IL-15 niche in thymus
Guangwei Cui (Kyoto University)
3-E-W30-10-O/P
An organ-wide transcriptome of collagen-producing cells identifies the core signature of steady-state murine fibroblasts
Shigeyuki Shichino (The University of Tokyo, AMED)

Category-2: B cells
2-B-W16-10-O/P
Dynamics of IRF4-dependent gene activation and repression during plasma cell differentiation
Kyoko Ochiai (Tohoku University School of Medicine, AMED-CREST)
2-B-W16-14-O/P
LRRK1 controls B-cell responses by regulating CARMA1-dependent NF-κB activation
Keiko Morimoto (Osaka University)

Category-3: T cells
1-G-W13-3-O/P
Timing and duration of MHC-I positive selection signals in the thymus reveal a novel compensatory signaling mechanism that prevents lineage fate errors
Motoko Kimura (Chiba University)
1-G-W14-11-O/P
Membrane lipid binding by SH2 domains of Lck and Zap70 regulates T cell receptor activation
You-Me Kim (Pohang University of Science and Technology)

Category-4: Helper T cells
3-G-W34-3-O/P
Gai-coupled non-canonical Hedgehog signaling in human Naive CD4 T lymphocytes.
Olga Elisseeva (Okinawa Institute of Science and Technology Graduate University)
3-G-W34-5-O/P
The microRNA-183/96/182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression
Kenji Ichiyama (Osaka University, Children's National Medical Center)

Category-5: Regulatory T cells
3-G-W35-5-O/P
Soluble form of CTLA-4 produced by regulatory T cells facilitates M2 macrophage differentiation in auto-inflammatory condition.r> Motonao Osaki (Kyoto University, Osaka University)
3-G-W35-8-O/P
Immunological significance of dual secretion of TGF-β3 and IL-10 from regulatory T cells
Toshihiko Komai (The University of Tokyo)

Category-6: Innate lymphocytes
1-C-W5-3-O/P
Identification of an alternative developmental pathway of Va14+ NKT cells from double-negative thymocytes
Nyambayar Dashtsoodol (RIKEN-IMS, Mongolian National University)
1-C-W6-7-O/P
IFN regulatory factor 2 controls ILC development by promoting PLZF+ILC progenitor generation.
Yohei Okubo (Shinshu University)

Category-7: Dendritic cells and macrophages
1-B-W3-1-O/P
Single-cell RNA-seq reveals a novel dendritic cell-primed early progenitor population
Daisuke Kurotaki (Yokohama City University)
1-B-W4-4-O/P
MafB is the primary regulator of complement component C1q
Michito Hamada (University of Tsukuba)

Category-10: Mast cells & granulocytes
2-E-W19-4-O/P
A critical role of ceramide-CD300f interaction in septic peritonitis
Kumi Izawa (Juntendo University)
2-E-W19-16-P
Basophil-selective tryptase mMCP-11 plays crucial roles in the development of IgE-mediated chronic allergic inflammation in the skin.
Misako Iki (Tokyo Medical and Dental University)

Category-11: Allergy
3-D-W28-5-O/P
The role of Tfh cells and DCs in particulate-induced iBALT formation in the lungs
Etsushi Kuroda (Osaka University, Health and Nutrition)
3-D-W29-6-O/P
Clec10a suppresses Der f-induced immune response and dermatitis
Kazumasa Kanemaru (University of Tsukuba)

Category-12: Cytokines and chemokines
2-G-W21-1-O/P
Regulation of IL-4 production in Group2 innate lymphoid cells
Yasutaka Motomura (RIKEN-IMS)
2-G-W21-5-O/P
HBV-induced exosomal miRNAs down-regulate the expression of IL-21 mRNA by binding to its 3’UTR
Yutaka Enomoto (The University of Tokyo)

Category-13: Immunological memory
3-F-W33-2-O/P
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance
3-F-W33-4-O/P
Molecular mechanisms for prevention of IgE-memory formation by membrane IgE
Kei Haniuda (Tokyo University of Science)

Category-14: Virus infection
1-E-W9-3-O/P
Visualizing immune responses to influenza virus in mouse lung by using two-photon microscopy
Hiroshi Ueki (The University of Tokyo)
1-E-W10-1-O/P
Modulation of the antiviral adaptor IPS-1-mediated innate immune responses by carboxylation
Tomohiko Okazaki (The University of Tokyo)

Category-15: Mycofungal/ parasite infection
3-C-W26-7-O/P
Effect of Secreted Immunoglobulin Deficiency in Anti-Leishmania Immunity
Piyarat Srinontong (Gifu University)
3-C-W26-19-O/P
Strategy of Zygomycete fungi to evade anti-fungal innate immunity
Masashi Kanayama (Duke University)

Category-16: Bacterial infection
3-C-W27-5-O/P
Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
Kouyuki Hirayasu (Osaka University)
3-C-W27-6-O/P
Recognition of mycobacterial lipid by Dendritic cell immunoactivating receptor
Kenji Toyonaga (Kagoshima University)

Category-17: Endogeneous innate immunity and inflammation
3-B-W24-17-O/P
Involvement of RNAi accessory factors in MDA5/LGP2-mediated cellular responses by Cardiovirus infection
Akihiko Komuro (Niigata University)
3-B-W24-20-O/P
Immune regulation through TRIM-regulated precision autophagy and secretion.
Tomonori Kimura (Osaka University)

Category-18: Mucosal-Skin Immunity
1-A-W1-15-O/P
Commensal bacteria-derived metabolite induce colonic IgA producing cells
Junya Isobe (Keio University)
1-A-W2-8-O/P
Immunization with GM-CSF-induced RALDH2-expressing dendritic cells induce antigen-specific IgA and Th responses in intestine

Category-19: Tolerance and Immune suppression
2-D-W18-6-O/P
Non-overlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
Baihao Zhang (Kyoto University, RIKEN-IMS)
2-D-W18-12-O/P
Hepatic IL-10 producing CD11b+ macrophage recruited in colitic mice prevent T-cell-dependent hepatitis via gut-liver axis
Nobuhito Taniki (Keio University)

Category-20: Organ-specific autoimmune diseases
3-F-W32-2-O/P
The anti-apoptotic effect of matrix metalloproteinase-2 suppresses streptozotocin-induced diabetes by activating the Akt signaling pathway
Kota Nishihama (Mie University)
3-F-W32-4-O/P
Regulation of neuroinflammation by a cellular metabolite in experimental autoimmune encephalomyelitis
Daisuke Kamimura (Hokkaido University)

Category-21: Inflammatory arthritis
2-C-W17-2-O/P
Dual Effect of 3-Bromopyruvate on Both Th17 and Treg Cell Differentiation and Dendritic Cell Activation Ameliorates Autoimmune Arthritis in Mice
Takaichi Okano (Kobe University)
2-C-W17-6-O/P
Histone lysine methylation and STAT3 differentially regulate constitutive nad IL-6-induced MMPs gene activation in rheumatoid arthritis synovial fibroblasts
Yasuto Araki (Saitama Medical University)

Category-22: Systemic autoimmune diseases
1-F-W11-5-O/P
IL-21 enhances the development of autoimmune myositis via the production of GM-CSF from gd T cells
Takahiro Kageyama (Chiba University)
1-F-W12-1-O/P
Cell-type-specific transcriptome analysis of peripheral blood mononuclear cells (PBMCs) revealed B cell contribution to systemic lupus erythematosus pathogenesis
Yusuke Takeshima (The University of Tokyo)

Category-23: Tumor immunity
2-A-W15-12-O/P
IL-33 promotes obesity-associated liver cancer development
Fumitaka Kamachi (Tokyo University of Science)
3-A-W22-5-O/P
A novel pathogenic role of interleukin-34 in cancer chemoresistance
Muhammad Baghdadi (Hokkaido University)

Category-24: Human Immunology (Immunointervention)
1-D-W7-11-O/P
Gene Modules Correlated with Disease Activity and Abatacept Treatment Identified with Weighted Gene Co-Expression Network Analysis of CD4+ T Cell Subsets of Rheumatoid Arthritis
Shuji Sumitomo (The University of Tokyo)
1-D-W8-2-O/P
Development of molecular targeted therapy for human acute GVHD in humanized mice
Genki Okumura (University of Tsukuba)

Category-25: Antigen presentation, Trafficking
3-E-W31-6-O/P
HLA-F and MHC open conformer cooperate in antigen presentation during the inflammatory response
Akiko Ishitani (Nara Medical University)
3-E-W31-8-O/P
Implications of Spns2-deficiency on S1P-driven lymphocytes egress, HEV-integrity and immunity.
Szandor Simmons (Osaka University)

2015年

Category-1: Hematopoiesis and Immune Environment
2-I-W32-7-O/P
Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection Ari Itoh-Nakadai (Tohoku University)
2-I-W32-10-O/P
Identification of cMoP and bona fide GMP in human umbilical cord blood
Shunsuke Kawamura (Tokyo Medical and Dental University)

Category-2: B cells
3-F-W42-2-O/P
Intrathymic licensing of immigrating peripheral B cells for T cell tolerance induction
Tomoyoshi Yamano (Ludwig-Maximilians-Universitat)
3-F-W42-3-O/P
Antigen-spe cific maturation of anti-nuclear antibodies in systemic lupus erythematosus
Shuhei Sakakibara (Osaka University)

Category-3: T cells
2-H-W30-1-O/P
A tumor suppressor Menin controls CD8 T cell senescence by regulating energy metabolism
Junpei Suzuki (Ehime University)
3-H-W46-3-O/P
Statistical analysis shows non-randomness of V/J gene selection in human TCR
Yotaro Katayama (The University of Tokyo)

Category-4: Helper T cells
1-H-W13-4-O/P
Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1
Yusuke Endo (Chiba University)
1-H-W14-11-O/P
Human CXCL13-producing CD4 T cells preferentially differentiate under IL-2-limitted environment
Hiroyuki Yoshitomi (Kyoto University)

Category-5: Regulatory T cells
3-G-W43-2-O/P
Establishment of regulatory T cell-specific super-enhancers
Yohko Kitagawa (Osaka University)
3-G-W43-6-O/P
Foxp3 changes its partners and genomic binding regions in regulatory T cells in response to IL-4 stimulation
Norihito Hayatsu (RIKEN-IMS)

Category-6: Innate lymphocytes
1-C-W4-7-O/P
Involvement of Natural Helper cells, a member of group 2 ILCs (ILC2) in the induction of obesity
Takaharu Sasaki (RIKEN-IMS)
1-C-W4-2-O/P
Identification of progenitor cells specific to ILC1s and ILC3s in adult intestine
Takashi Ebihara (Washington University)

Category-7: Dendritic cells and macrophages
2-C-W20-1-O/P
Transcription factor IRF8 governs the enhancer landscape dynamics in mononuclear phagocyte development
Daisuke Kurotaki (Yokohama City University)
3-C-W36-2-O/P
Unique role of Cbfb2 variant in Langerhans cell development
Mari Tenno (RIKEN-IMS)

Category-8: Antigen presentation
1-D-W5-2-O/P
p62/Sqstm1 plays a specific role for CD8+ T cell activation in antigen presenting cells following IFN-γ-induced disruption of the Toxoplasma gondii parasitophorous vacuoles
Youngae Lee (Osaka University)
1-D-W5-13-O/P
Discovery of lipopeptide Ag-presenting molecules: its molecular identity and X-ray crystallographic structure
Daisuke Morita (Kyoto University)

Category-9: Trafficking
2-I-W31-5-O/P
Spinster-homologue-2 (Spns2) controls S1P-driven lymphocyte egress from lymphoid organs
Szandor Simmons (Osaka University)

Category-10: Mast cells & granulocytes
1-C-W3-3-O/P
The hIstidine transporter SLC15A4 regulates allergic responses by tuning the endo/lysosomal condition of mast cells
Toshihiko Kobayashi (National Center for Global Health & Medicine)
1-C-W3-4-O/P
The novel role of LMIR7/CLM-3 in mast cell- and IgE-dependent anaphylaxis
Masamichi Isobe (Juntendo University)

Category-11: Allergy
3-I-W47-4-O/P
Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways
Shoko Akasaki (Hyogo College of Medicine)
3-I-W48-4-O/P
CXCL4 is a novel nickel binding protein and augments nickel allergy at elicitation phase
Toshinobu Kuroishi (Tohoku University)

Category-12: Cytokines and chemokines
1-I-W15-4-O/P
Inflammation amplifier regulatory molecule NSZ1 controls NFκB specific chromatin accessibility via alternative splicing of a DNA methyltransferase
Toru Atsumi (Hokkaido University)
1-I-W16-8-O/P
Involvement of a novel alpha9 integrin ligand, XCL1/Lymphotactin in autoimmune diseases
Naoki Matsumoto (Hokkaido University)

Category-13: Immunological memory
1-G-W11-3-O/P
Distinct germinal center selection at local sites shapes memory B cell response to viral escape
Yu Adachi (National Institute of Infectious Diseases)
1-G-W11-5-O/P
A role of IL-9 receptor on B cells in the T-dependent immune responses
Shogo Takatsuka (Tokyo University of Science)

Category-14: Virus infection
1-F-W9-2-O/P
The role of mTOR in TLR3 responses to Herpes Simplex Virus infection
Ryota Sato (The University of Tokyo)
1-F-W10-6-O/P
CD150 costimulation enhances SHIV-specific TFH cell responses in non-human primate models
Takuya Yamamoto (National Institutes of Biomedical Innovation, Health and Nutrition)

Category-15: Mycofungal/ parasite infection
1-E-W7-14-O/P
Batf2 regulates Th17 responses by suppression of IL-23 production during Trypanosoma cruzi infection
Shoko Kitada (Osaka University)
1-E-W7-18-O/P
Malaria-induced bone disorder triggered by chronic inflammation in the bone
Michelle Sue Jann Lee (Osaka University)

Category-16: Bacterial infection
3-G-W44-6-O/P
Analysis of a novel subset of IFN-γ-producing DN2a γδ T cells in the periphery of mice
Shinya Hatano (Kyushu University)
3-G-W44-4-O/P
CD300a on mast cells and dendritic cells control the pathogenesis of experimental sepsis
Gamage Sanath Udayanga Kankanam (University of Tsukuba)

Category-17: Endogeneous innate immunity and inflammation
1-G-W12-1-O/P
MD-1 negatively regulates B cell-related inflammation
Natsuko Tanimura (The University of Tokyo)
2-G-W27-3-O/P
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection
Ryo Narita (Kyoto University)

Category-18: Mucosal-Skin Immunity
3-E-W40-1-O/P
The role of the gut microbiota in the development of experimental autoimmune encephalomyelitis
Eiji Miyauchi (RIKEN-IMS)
1-E-W8-1-O/P
Lypd8 maintains gut homeostasis through separation of flagellated bacteria and colonic epithelia
Ryu Okumura (Osaka University)

Category-19: Tolerance and Immune suppression
2-C-W19-3-O/P
Establishment of thymus transplant model to analyze peripheral T cell tolerance against pemphigus autoantigen, desmoglein 3
Hisato Iriki (Keio University)
2-C-W19-4-O/P
The strength of inhibition by LAG-3 depends on properties of APCs
Takumi Maruhashi (Tokushima University)

Category-20: Organ-specific autoimmune diseases
2-F-W25-1-O/P
RANKL on T cells is essential for inflammation in the CNS during EAE
Matteo Maurizio Guerrini (The University of Tokyo)
2-F-W26-6-O/P
Activated increased number of T follicular helper subset 2 correlates with increased levels of IgG4, IL-4 and plasmablasts in IgG4-related disease
Mitsuhiro Akiyama (Keio University )

Category-21: Inflammatory arthritis
2-B-W17-1-O/P
Rheumatoid arthritis patients-derived gut microbiota induce Th17-mediated arthritis in SKG mice
Yuichi Maeda (Osaka University)
2-B-W17-2-O/P
TIARP regulates CXCL2/CXCR2 mediated neutrophil migration via the inhibition of IL-6
Asuka Inoue (University of Tsukuba)

Category-22: Systemic autoimmune diseases
1-B-W1-5-O/P
Regulatory roles of TGF-β3 in lupus pathogenesis
Toshihiko Komai (The University of Tokyo)
1-B-W2-1-O/P
Myeloperoxidase/HLA class II complexes are targets for autoantibodies in ANCA-associated vasculitis
Ryosuke Hiwa (Kyoto University)

Category-23: Tumor immunity
2-D-W21-8-O/P
Metformin administration stimulates glycolysis of effector memory CD8TIL in tumor microenvironment Shingo Eikawa (Okayama University)
3-D-W38-5-O/P
Tumor cell death accelerated migration of tumor infiltrating dendritic cells into draining lymph nodes
Taiki Moriya (Osaka Ohtani University)

Category-24: Human Immunology (Immunointervention)
2-B-W18-3-O/P
The ulcerative colitis-associated gene RNF186 regulates gut homeostasis
Kosuke Fujimoto (Osaka University)
3-B-W34-5-O/P
Development of a human hemato-lymphoid system in human cytokine knock-in Rag2-/-Il2rg-/- mice engrafted with peripheral blood mobilized CD34+ cells
Yasuyuki Saito (Kobe University / University Hospital Zurich)

2014年

Category-1: Hematopoiesisand Immune Environment
2-H-W32-5-0/P : YANAGIHARA Toyoshi (Kyushu University)
Identification of a novel molecule essential for Aire expression and self-tolerance

Category-2: B cells
2-G-W29-8-O/P : YAMAZAKI Nao (National Center for Global health and Medicine)
IgM+ plasma cells contribute to the sufficient production of IgG by secreting IL-10 and IL-13

Category-3: T cells
2-D-W23-6-O/P : KAMIMURA Daisuke (Hokkaido University)
Characterization of T-Red mutant mouse line having reduced naive T cells

Category-4: Helper T cells
3-E-W44-5-O/P : SANO Teruyuki (New York University)
Cytokine requirement for Th17 cell differentiation in response to Segmented filamentous bacteria colonization

Category-5: Regulatory T cells
3-D-W42-16-O/P : MURAKAMI Ryuichi (RIKEN)
Foxp3 and BATF cooperatively controls regulatory T cell homeostasis in non-lymphoid tissues

Category-6: Innate lymphocytes
1-B-W2-8-O/P : MIYAJIMA Michio (RIKEN)
Type III innate lymphoid cells enhance antibody production by splenic marginal zone B cells

Category-7: Dendritic cells and macrophages
2-C-W22-1-O/P : NIIZUMA Kouta (University of Tsukuba)
Identification and characterization of human CD300H, the eighth member of the CD300-family receptors

Category-8: Antigen presentation
2-E-W26-9-O/P : KISHIDA Kazuki (Osaka University)
Processing of cellular misfolded protein complexed with MHC class II molecules

Category-9: Trafficking
1-F-W9-13-O/P : HARADA Yosuke (Kyushu University)
The role of DOCK8 in migration and activation of effector CD4+ T cells during immune responses

Category-10: Mast cells & Granulocytes
2-J-W36-7-O/P : ANDO Tomoaki (RIKEN)
Mast cells and the Stat5 activation pathway are required for allergen-induced and spontaneous skin inflammation

Category-11: Allergy
1-J-W18-3-O/P : TSAI Shin han (Osaka University)
E-NPP3 (CD203c) negatively regulates ATP-dependent allergic responses by basophils and mast cells

Category-12: Cytokines and chemokines
3-G-W47-17-O/P : OGURA Hideki (Hokkaido University)
ZFZ (zinc finger motif containing protein Z) promotes the inflammation amplifier by regulating NF-κB DNA binding activity

Category-13: Immunological memory
1-G-W11-1-O/P : KONDO Taisuke (Keio University)
Generation of mouse CD4⁺ stem cell memory T cells by Wnt signaling and by Notch signaling

Category-14: Virus infection
2-I-W34-2-O/P : SUGIMOTO Naoshi (Kyoto University)
Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system

Category-15: Mycofungal / parasite infection
3-I-W52-4-O/P : UENO Keigo (National Institute of Infectious Diseases)
Efficacy of dendritic cell-mediated immunization for the pulmonary infection with highly virulent fungus Cryptococcus gatti

Category-16: Bacterial infection
3-I-W51-9-O/P : TSUCHIYA Kohsuke (Kyoto University)
NLRP3 and ASC contribute to host defense against pneumococcal pneumonia in an inflammasome-independent manner

Category-17: Endogeneous innate immunity and inflammation
2-E-W25-6-O/P : IMAMURA Tomoko (Kyoto University)
N4bp1-mediated nascent RNA decay controls cytokine mRNA expression

Category-18: Mucosal-Skin Immunity
3-H-W49-5-O/P : GOTO Yoshiyuki (Columbia University)
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation

Category-19: Tolerance and Immune suppression
1-H-W13-3-O/P : LIN Youwei (NCNP)
Inverse vaccination for autoimmune diseases by sensitization of superior dominant peptide through efficient induction of functionally stable regulatory T cells possessing high antigen-specificity

Category-20: Organ-specific autoimmune diseases
1-F-W10-2-O/P : ASASHIMA Hiromitsu (University of Tsukuba)
The suppressive ability of altered peptide ligands to M3R reactive T cells in M3R induced autoimmune sialadenitis

Category-21: Rheumatoid arthritis
2-F-W28-1-O/P : KONDO Yuya (University of Tsukuba)
RORγt+Foxp3+ regulatory T cells regulates the development of autoimmune arthritis in mice

Category-22: Systemic autoimmune diseases
3-F-W45-7-O/P : MORITA Kaoru (The University of Tokyo)
The role of Egr2 and Egr3 in regulating immune homeostasis

Category-23: Tumor immunity
2-B-W19-8-O/P : MAEDA Takuya (Kyoto University)
Regeneration of EB virus LMP2 specific CTLs utilizing iPS technology

Category-24: Human Immunology (immunointervention)
3-C-W40-7-O/P : NAKACHI Shinichiro (The University of Tokyo)
A quantitative alteration of human CD4+CD25-LAG3+Tregs in patients with rheumatoid arthritis