Program
Special lecture
1PL01
Date:November 9th 11:10-12:00 Place: Room 1 (Reception Hall)
Molecular Basis of Oxidative Stress Response and Its Perturbation
Speaker：Masayuki Yamamoto (Tohoku University)
Chair：Tetsuya Okajima（Nagoya University）
2PL01
Date:November 10th 11:10-12:00 Place: Room 1 (Reception Hall)
Dynamics of Function and Regulation of the Endoplasmic Reticulum
Speaker：Kazutoshi Mori (Kyoto University)
Chair：Ken Kitajima（Nagoya University）
3PL01 (Pre-recorded lectures will be screened.)
- THE NOBEL PRIZE IN CHEMISTRY 2022
Date:November 11th 11:10-12:00 Place: Room 1 (Reception Hall)
Therapeutic Opportunities in glycoscience
Speaker：Carolyn R. Bertozzi
（Chemistry, Engineering & Medicine for Human Health Stanford University）
Chair：Tadashi Suzuki（RIKEN）
List
| Session No. | Date | Venue | Theme |
|---|---|---|---|
1S01m | November 9th | Room 1（Reception Hall） | |
1S02m | November 9th | Room 2（141+142） | |
1S03m | November 9th | Room 3（International Conference Rooms） | |
1S04m | November 9th | Room 4（234） | |
1S05m | November 9th | Room 5（231） | |
1S06m | November 9th | Room 6（232+233） | |
1S07m | November 9th | Room 7（224） | |
1S08m | November 9th | Room 8（221） | |
1S09m | November 9th | Room 9（222） | |
1S10m | November 9th | Room 10（223） | |
1S11m | November 9th | Room 11（211） | |
1S12m | November 9th | Room 12（212） | |
1S13m | November 9th | Room 13（431） | |
1S14m | November 9th | Room 14（432） | |
1S15m | November 9th | Room 15（131+132） | |
1S16m | November 9th | Room 16（133+134） | |
1S01a | November 9th | Room 1（Reception Hall） | |
1S01e | November 9th | Room 1（Reception Hall） | |
1S02e | November 9th | Room 2（141+142） | |
1S03e | November 9th | Room 3（International Conference Rooms） | |
1S04e | November 9th | Room 4（234） | |
1S05e | November 9th | Room 5（231） | |
1S06e | November 9th | Room 6（232+233） | |
1S07e | November 9th | Room 7（224） | |
1S08e | November 9th | Room 8（221） | |
1S09e | November 9th | Room 9（222） | |
1S10e | November 9th | Room 10（223） | |
1S11e | November 9th | Room 11（211） | |
1S12e | November 9th | Room 12（212） | |
1S13e | November 9th | Room 13（431） | |
1S14e | November 9th | Room 14（432） | |
1S15e | November 9th | Room 15（131+132） | |
1S16e | November 9th | Room 16（133+134） | |
2S02m | November 10th | Room 2（141+142） | |
2S03m | November 10th | Room 3（International Conference Rooms） | |
2S04m | November 10th | Room 4（234） | |
2S05m | November 10th | Room 5（231） | |
2S06m | November 10th | Room 6（232+233） | |
2S07m | November 10th | Room 7（224） | |
2S08m | November 10th | Room 8（221） | |
2S09m | November 10th | Room 9（222） | |
2S10m | November 10th | Room 10（223） | |
2S11m | November 10th | Room 11（211） | |
2S12m | November 10th | Room 12（212） | |
2S13m | November 10th | Room 13（431） | |
2S14m | November 10th | Room 14（432） | |
2S15m | November 10th | Room 15（131+132） | |
2S16m | November 10th | Room 16（133+134） | |
2S01e | November 10th | Room 1（Reception Hall） | |
2S02e | November 10th | Room 2（141+142） | |
2S03e | November 10th | Room 3（International Conference Rooms） | |
2S04e | November 10th | Room 4（234） | |
2S05e | November 10th | Room 5（231） | |
2S06e | November 10th | Room 6（232+233） | |
2S07e | November 10th | Room 7（224） | |
2S08e | November 10th | Room 8（221） | |
2S09e | November 10th | Room 9（222） | |
2S10e | November 10th | Room 10（223） | |
2S11e | November 10th | Room 11（211） | |
2S12e | November 10th | Room 12（212） | |
2S13e | November 10th | Room 13（431） | |
2S14e | November 10th | Room 14（432） | |
2S15e | November 10th | Room 15（131+132） | |
2S16e | November 10th | Room 16（133+134） | |
3S01m | November 11th | Room 1（Reception Hall） | |
3S02m | November 11th | Room 2（141+142） | |
3S03m | November 11th | Room 3（International Conference Rooms） | |
3S04m | November 11th | Room 4（234） | |
3S05m | November 11th | Room 5（231） | |
3S06m | November 11th | Room 6（232+233） | |
3S07m | November 11th | Room 7（224） | |
3S08m | November 11th | Room 8（221） | |
3S09m | November 11th | Room 9（222） | |
3S10m | November 11th | Room 10（223） | |
3S11m | November 11th | Room 11（211） | |
3S12m | November 11th | Room 12（212） | |
3S13m | November 11th | Room 13（431） | |
3S14m | November 11th | Room 14（432） | |
3S15m | November 11th | Room 15（131+132） | |
3S16m | November 11th | Room 16（133+134） |
Overview
1S01m
Date:November 9th 9:00-11:00 Place: Room 1（Reception Hall）
Exploring the roles of “Biometals" from the perspective of the hierarchical structure of life
organizer:
Taiho Kambe（Graduate School of Biostudies, Kyoto University)
Kouhei Tsumoto（Graduate School of Engineering, The University of Tokyo)
sponsor: Integrated Bio-metal Science: Research to Explore Dynamics of Metals in Cellular System
Koichiro Ishimori（Hokkaido University)
Hitomi Sawai（University of Hyogo)
Junpei Takano（Osaka Prefecture University)
Yoshiaki Furukawa（Keio University)
Taiho Kambe（Kyoto University)
Hitomi Sawai（University of Hyogo)
Junpei Takano（Osaka Prefecture University)
Yoshiaki Furukawa（Keio University)
Taiho Kambe（Kyoto University)
About 30% of the proteome of living organisms is estimated to contain the metal binding motif. These proteins never express their biological functions until they acquire metal ions within their metal binding motifs. Accordingly, dynamics of the metals such as their uptake, transport, mobilization, utilization, and sensing strictly regulated in the cells. Clarification of these molecular mechanism is essential for understanding the living organisms. In this symposium, we will focus on “Biometal”, such as iron, zinc, copper, and manganese, and will discuss how Biometals play pivotal roles in the life, how disturbance of the homeostatic maintenance of Biometals causes diseases, and why Biometals is attractive as the potential therapeutic targets, from the viewpoints of small molecules, proteins, cells, tissues, and intact organism.
1S02m
Date:November 9th 9:00-11:00 Place: Room 2（141+142）
New Trends in AI and Data-Driven Life Science Research
organizer:
Teppei Shimamura（Nagoya University Graduate School of Medicine)
Tsuyoshi Osawa（Research Center for Advanced Science and Technology, The University of Tokyo)
Sadao Ota（The University of Tokyo)
Itoshi Nikaido（RIKEN / Tokyo Medical and Dental University)
Yusuke Hirabayashi（Graduate School of Engineering, The University of Tokyo)
Teppei Shimamura（Nagoya University Graduate School of Medicine)
Keisuke Kataoka（Keio University / National Cancer Center Research Institute)
Itoshi Nikaido（RIKEN / Tokyo Medical and Dental University)
Yusuke Hirabayashi（Graduate School of Engineering, The University of Tokyo)
Teppei Shimamura（Nagoya University Graduate School of Medicine)
Keisuke Kataoka（Keio University / National Cancer Center Research Institute)
With technological innovations such as next-generation sequencers, mass spectrometers, and imaging, multi-level biological information is being accumulated, but many life scientists are struggling to analyze them. To utilize big-data to create innovative knowledge that transcends known disciplines, it is essential to conduct interdisciplinary research that utilizes wisdom and new theories cultivated in different fields, such as mathematical science, informatics, and physics. On the other hand, many life science researchers may still feel uncomfortable about how to conduct cross-disciplinary research and what exactly they should do. In this sympodium, researchers who are approaching cancer and neuroscience with the latest analysis technologies such as multi-omics analysis and AI, as well as cutting-edge imaging technologies, will gather to introduce the latest measurement and analysis technologies. We will introduce and provide an opportunity for young researchers to enter new fields.
1S03m
Date:November 9th 9:00-11:00 Place: Room 3（International Conference Rooms）
Character of protein is regulated and diversified in the ER and Golgi
organizer:
Satoshi Ninagawa（Biosignal Research center, Kobe University)
Yasuhiko Kizuka（Institute for Glyco-core Research, Gifu University)
Satoshi Ninagawa（Biosignal Research center, Kobe University)
Hiroyuki Ishikawa（Graduate School of Science, Chiba University)
Yuko Arioka（Nagoya University Hospital)
Masaki Okumura（FRIS, Tohoku university)
Ikuo K Suzuki（Graduate School of Sciences, Tokyo University)
Hirokazu Yagi（Graduate School of Pharmaceutical Sciences, Nagoya City University)
Hiroyuki Ishikawa（Graduate School of Science, Chiba University)
Yuko Arioka（Nagoya University Hospital)
Masaki Okumura（FRIS, Tohoku university)
Ikuo K Suzuki（Graduate School of Sciences, Tokyo University)
Hirokazu Yagi（Graduate School of Pharmaceutical Sciences, Nagoya City University)
About one-third of all proteins are synthesized in the endoplasmic reticulum (ER). Their functions are not solely defined by amino acid sequences but diversified by post-translational protein modifications in the ER and Golgi apparatus. This means that diversity of protein characters originated from genomic information are further amplified through post-translational modifications in these organelles, which leads to protein-individuality. Ultimately, accumulation of such protein-individuality shapes our personality and health states. In this symposium, cutting-edge young researchers will discuss how protein-individuality is regulated or diverged, by focusing on post-translational modifications such as N-glycosylation, O-glycosylation, disulfide bonding and phosphorylation, and genomic variation impacting those modifications.
1S04m
Date:November 9th 9:00-11:00 Place: Room 4（234）
Role of immunometabolism in the pathophysiology of chronic diseases
organizer:
Takayoshi Suganami（Nagoya University, Research Institute of Environmental Medicine)
Hiroshi inoue（Kanazawa University, Division of Transdisciplinary Sciences)
Masaru Ishii（Osaka University, Graduate School of Medicine)
Jun Yoshino（Keio University, School of Medicine)
Yuka Inaba（Kanazawa University, Division of Transdisciplinary Sciences)
Hiroki Sekine（Tohoku University, Institute of Development, Aging and Cancer)
Ayaka Ito（Nagoya University, Research Institute of Environmental Medicine)
Jun Yoshino（Keio University, School of Medicine)
Yuka Inaba（Kanazawa University, Division of Transdisciplinary Sciences)
Hiroki Sekine（Tohoku University, Institute of Development, Aging and Cancer)
Ayaka Ito（Nagoya University, Research Institute of Environmental Medicine)
Chronic inflammation is a common molecular basis of various chronic diseases. Recently, it is appreciated that there is a reciprocal crosstalk between metabolism and inflammation. For instance, chronic inflammation in metabolic organs regulates systemic insulin resistance. Moreover, accumulating evidence indicates that cellular metabolism controls immune cell functions. Thus, substantial attention has been paid to the emerging research area “immunometabolism”. In this symposium, we will discuss the recent progress of “immunometabolism” in the pathogenesis of chronic diseases with complex etiologies.
1S05m
Date:November 9th 9:00-11:00 Place: Room 5（231）
Epithelial dynamics and organismal responses
organizer:
Tatsushi Igaki（Graduate School of Biostudies, Kyoto University)
Yukako Oda（Institute for Frontier Life and Medical Sciences, Kyoto University)
Yuko Shimada（Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba)
Asako Shindo（Institute of Molecular Embryology and Genetics)
Masato Enomoto（Graduate School of Biostudies, Kyoto University)
Hiroyuki Nakajima（National Cerebral and Cardiovascular Center)
Yukako Oda（Institute for Frontier Life and Medical Sciences, Kyoto University)
Asako Shindo（Institute of Molecular Embryology and Genetics)
Masato Enomoto（Graduate School of Biostudies, Kyoto University)
Hiroyuki Nakajima（National Cerebral and Cardiovascular Center)
Yukako Oda（Institute for Frontier Life and Medical Sciences, Kyoto University)
Epithelial tissue dynamically changes its structure and function in response to a variety of internal/external stresses and local/systemic factors. On the other hand, changes in epithelial dynamics can trigger various organismal responses via local/systemic factors and cell-cell communications. It has recently become clear that mutual linkage between epithelial dynamics and organismal responses plays crucial roles in dynamic biological processes such as morphogenesis, tissue repair, and inflammatory responses. In this symposium, up-and-coming researchers from various backgrounds will introduce the latest findings on the molecular coupling between epithelial dynamics and organismal responses and discuss the underlying mechanisms, biological concepts, and new questions.
1S06m
Date:November 9th 9:00-11:00 Place: Room 6（232+233）
Organelle surveillance system: How cells sense the quantity and quality of organelles
organizer:
Yasushi Tamura（Yamagata University)
Shigeomi Shimizu（Tokyo Medical and Dental University)
Yoko Ito（Ochanomizu university)
Masato Nakai（Osaka University)
Kamikawa Yasunao（Hiroshima University)
Hiderou Yoshida（University of Hyogo)
Yukio Fujiki（Kyushu University)
Yasushi Tamura（Yamagata University)
Masato Nakai（Osaka University)
Kamikawa Yasunao（Hiroshima University)
Hiderou Yoshida（University of Hyogo)
Yukio Fujiki（Kyushu University)
Yasushi Tamura（Yamagata University)
Previous organelle studies have mainly focused on identifying and functional characterization of organelles’ constituents, contributing to understanding the organelles in the steady-state. However, since organelles are dynamic membrane structures that undergo constant formation, development, and degradation, it is essential to focus on organelles in a non-equilibrium state where the organelle mass and functions are changing. Specifically, organelle membranes dramatically expand depending on the extracellular environment and stress conditions. On the other hand, organelles are entirely digested depending on the cell type. In this symposium, we define the “organelle surveillance system” as the mechanism by which cells sense the quantity and quality of appropriate organelles and determine the organelle fates, and discuss from a wide range of viewpoints, from budding yeast to plant and animal cells.
1S07m
Date:November 9th 9:00-11:00 Place: Room 7（224）
Exploring mechanisms of tissue fibrosis utilizing disease models
organizer:
Minoru Tanaka（Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine)
Hiroyasu Nakano（Department of Biochemistry, Toho University School of Medicine)
Yuichi Tsuchiya（Toho University School of Medicine)
Taketomo Kido（Institute for Quantitative Biosciences, The University of Tokyo)
Shigeyuki Shichino（Research Institute of Biomedical Sciences, Tokyo University of Science)
Michio Nakaya（Graduate School of Pharmaceutical Sciences Kyushu University)
Atsushi Enomoto（Nagoya University Graduate School of Medicine)
Minoru Tanaka（Research Institute, National Center for Global Health and Medicine)
Taketomo Kido（Institute for Quantitative Biosciences, The University of Tokyo)
Shigeyuki Shichino（Research Institute of Biomedical Sciences, Tokyo University of Science)
Michio Nakaya（Graduate School of Pharmaceutical Sciences Kyushu University)
Atsushi Enomoto（Nagoya University Graduate School of Medicine)
Minoru Tanaka（Research Institute, National Center for Global Health and Medicine)
Tissue fibrosis characterized by excessive accumulation of extracellular matrixes, including collagens, is induced by several factors. Progressive fibrosis results in aberrant tissue hardening and remodeling, leading to dysfunction, affecting vital prognosis in various diseases. Also, in some cancers, it has been revealed that fibrosis induced by cancer-associated fibroblasts is responsible for the resistance to treatment. However, effective therapy for tissue fibrosis has not been developed. Because the relevant cells for the formation of fibrosis vary in organs and cancers, the elucidation of regulatory mechanisms underlying fibrosis is required according to the designated tissues. In this symposium, researchers studying fibrosis in the field of liver, heart, lung, and cancers will discuss the latest research subjects to argue future directions and possibilities for the treatment of fibrosis.
1S08m
Date:November 9th 9:00-11:00 Place: Room 8（221）
Anthology of latest mitochondrial research
organizer:
Yasunori Watanabe（Yamagata University)
Koji Yamano（Tokyo Metropolitan Institute of Medical Science)
Takaya Ishihara（Osaka University)
Waka Kojima（Tokyo Metropolitan Institute of Medical Science)
Kanae Ando（Tokyo Metropolitan University)
Tomotake Kanki（Niigata University)
Yasunori Watanabe（Yamagata University)
Nozomu Kono（The University of Tokyo)
Waka Kojima（Tokyo Metropolitan Institute of Medical Science)
Kanae Ando（Tokyo Metropolitan University)
Tomotake Kanki（Niigata University)
Yasunori Watanabe（Yamagata University)
Nozomu Kono（The University of Tokyo)
Mitochondria are essential organelles in eukaryotic cells. They have various roles, in cell homeostasis, including energy production, amino-acid synthesis, lipid metabolism, calcium sensing and immune response. Recent studies have revealed that dynamics of mitochondrial morphology is important for distribution of mitochondrial DNA and that mitochondria detect various stresses and/or aging signals, which induce the organelle degradation via autophagy. Furthermore, many factors mediating lipid-trafficking in and out of mitochondria have been discovered. Mitochondrial dysfunctions are associated various human diseases. In this symposium, to facilitate comprehensive understanding of mitochondrial functions and homeostasis, we will invite energetic mitochondrial researchers and discuss multifaceted mitochondrial functions as “anthology of mitochondrial research”.
1S09m
Date:November 9th 9:00-11:00 Place: Room 9（222）
Protein cross-linking enzyme, transglutaminase, is involved in multiple biological events
organizer:
Kiyotaka Hitomi（Grad. Sch. Pharm. Sci., Nagoya University)
Masayoshi Souri（Grad. Sch. Med. Sci., Yamagata University)
Kiyotaka Hitomi（Grad. Sch. Pharm. Sci. Nagoya Univ.)
Masayoshi Souri（Grad. Sch. Med. Sci., Yamagata Univ.)
Fumihiko Nagano（Grad. Sch. Med., Nagoya Univ.)
Katsumitsu Shimada（Matsumoto Dental Univ. )
Hideki Tatsukawa（Grad. Sch. Pharm. Sci. Nagoya Univ.)
Toshio Shibata（Grad. Sch. Sci., Kyusyu Univ. )
Masayoshi Souri（Grad. Sch. Med. Sci., Yamagata Univ.)
Fumihiko Nagano（Grad. Sch. Med., Nagoya Univ.)
Katsumitsu Shimada（Matsumoto Dental Univ. )
Hideki Tatsukawa（Grad. Sch. Pharm. Sci. Nagoya Univ.)
Toshio Shibata（Grad. Sch. Sci., Kyusyu Univ. )
Human transglutaminase (TGase) is an enzyme family that catalyzes cross-linking reaction in various proteins. By modification of their structure and functions of the substrate proteins, this enzymatic reaction is involved in several biological events, such as blood coagulation, apoptosis and skin formation. The catalytic activity of TGase is strictly regulated and the aberrant activity causes abnormal blood coagulation, fibrosis, and skin diseases. Several investigations have been developed with regard to the regulatory mechanism of expression and activity as well as physiological functions of TGase. In this symposium, we would like to shed light on biological events for TGase for contribution to barrier function and maintenance of homeostasis, in various tissues and cell system.
1S10m
Date:November 9th 9:00-11:00 Place: Room 10（223）
Fusion of “chemistry, materials engineering, and life sciences" for advancing biomaterials
organizer:
Ken-ichi Mizutani（Graduate School of Pharmaceutical Sciences, Kobe Gakuin University)
Koji Nagahama（Faculty of frontiers of innovative research in science and technology, Konan University)
Chie Kojima（Graduate School of Engineering, Osaka Prefecture University)
Itsuki Ajioka（Center for Brain Integration Research, Tokyo Medical and Dental University)
Koji Nagahama（Faculty of frontiers of innovative research in science and technology, Konan University)
Ken-ichi Mizutani（Graduate School of Pharmaceutical Sciences, Kobe Gakuin University)
Itsuki Ajioka（Center for Brain Integration Research, Tokyo Medical and Dental University)
Koji Nagahama（Faculty of frontiers of innovative research in science and technology, Konan University)
Ken-ichi Mizutani（Graduate School of Pharmaceutical Sciences, Kobe Gakuin University)
Several investigations have been developed with regard to the regulatory mechanism of expression and activity as well as physiological functions of TGase. In this symposium, we would like to shed light on biological events for TGase for contribution to barrier function and maintenance of homeostasis, in various tissues and cell system.
1S11m
Date:November 9th 9:00-11:00 Place: Room 11（211）
Research Frontiers in Mitochondria-Associated Diseases
organizer:
Mikako Yagi（Kyushu UniversityDepartment of Health Sciences Graduate School of Medical Sciences)
Takehiro Yasukawa（Juntendo UniversitySchool of Medicine, Department of Pathology and Oncology)
Hirofumi Arakawa（National Cancer Center Research Institute)
Yoko Tabe（Juntendo University)
Yuzuru Imai（Juntendo University)
Kota Yanagitani（Kyushu University)
Mizuki Hayashishita（Nagasaki University)
Mikako Yagi（Kyushu University)
Yoko Tabe（Juntendo University)
Yuzuru Imai（Juntendo University)
Kota Yanagitani（Kyushu University)
Mizuki Hayashishita（Nagasaki University)
Mikako Yagi（Kyushu University)
It is widely known that mitochondria generate most ATP in the cell. They are also involved in various cellular activities, such as metabolism, immune response, ion balancing and signal transduction, and cooperate with other organelles to maintain the cell homeostasis. Thus, mitochondrial quality control is fundamental to the cell homeostasis and therefore to life. Not surprisingly, mitochondrial abnormalities are associated with various diseases including mitochondrial disease, cancer, neurodegeneration, cardiomyopathy, diabetes and metabolic syndrome. This symposium will showcase the link between mitochondria and disease and discuss the molecular pathogenesis and therapy. It will provide a unique opportunity to meet cutting-edge researches focusing on mitochondria in basic, applied and clinical aspects.
1S12m
Date:November 9th 9:00-11:00 Place: Room 12（212）
Animal models of aging research: its roles and limitations
organizer:
Ryoya Takahashi（Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University)
Yoshikazu Higami（Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
sponsor: Japan Society for Biomedical Gerontology
Ryoya Takahashi（Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University)
Kazutaka Akagi（Research Center for Pre-disease Science, University of Toyama)
Masanori Hosokawa（The Faculty of Health Science, Kyoto Koka Women’s University)
Takahiko Shimizu（Aging Stress Response Research Project Team, Research Institute, National Center for Geriatrics and Gerontology)
Mitsuo Maruyama（Department of Inflammation and Immunosenescence, GSRC, National Center for Geriatrics and Gerontology)
Yoshikazu Higami（Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Kazutaka Akagi（Research Center for Pre-disease Science, University of Toyama)
Masanori Hosokawa（The Faculty of Health Science, Kyoto Koka Women’s University)
Takahiko Shimizu（Aging Stress Response Research Project Team, Research Institute, National Center for Geriatrics and Gerontology)
Mitsuo Maruyama（Department of Inflammation and Immunosenescence, GSRC, National Center for Geriatrics and Gerontology)
Yoshikazu Higami（Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Various organisms from yeast to mammals are used for aging research. Although aging is highly multi-factorial, complex, and particular to each species, it has much in common. The recent development of genetic engineering technology has greatly contributed to the understanding of genetic mechanisms of aging. But at the same time, the complexity of the network of aging-related genes has begun to be revealed. The main theme of the symposium is “Animal models of aging research: its roles and limitations”. In this symposium, the Japan Society for Biomedical Gerontology members who research on aging mechanisms using various aging anima model are invited. This symposium will be an opportunity to find hints for new approaches to aging research for the JBS members.
1S13m
Date:November 9th 9:00-11:00 Place: Room 13（431）
Advances in neuroscience research through the development of novel protein methods
organizer:
Sayaka Takemoto-Kimura（Research Institute of Environmental Medicine, Nagoya University)
Takayasu Mikuni（Brain Research Institute Niigata University)
Etsuo Susaki（Juntendo University Graduate School of Medicine)
Tetsuya Kono（Keio University)
Sayaka Takemoto（Nagoya University)
Takayasu Mikuni（Niigata University)
Tetsuya Kono（Keio University)
Sayaka Takemoto（Nagoya University)
Takayasu Mikuni（Niigata University)
The emerging methods for protein-related research have resulted in remarkable progress in the field of biology in recent years, which has also disseminated to neuroscience research, thereby expanding the knowledge in these fields. In this symposium, researchers investigating brain mechanisms using various protein methods will present their recent findings to provide an opportunity for the exchange of ideas, now and in the future, in these rapidly advancing fields.
1S14m
Date:November 9th 9:00-11:00 Place: Room 14（432）
Lipid scrambling on organelles and plasma membranes
organizer:
Jun Suzuki（Kyoto University)
Nobuo Noda（Institute for Microbial Chemistry)
Masahiro Maruoka（Kyoto University)
Kazuaki Matoba（Institute for Microbial Chemistry)
Taroh Kinoshita（Osaka University)
Noboru Mizushima（The University of Tokyo)
Asuka Nanbo（Nagasaki University)
Kazuaki Matoba（Institute for Microbial Chemistry)
Taroh Kinoshita（Osaka University)
Noboru Mizushima（The University of Tokyo)
Asuka Nanbo（Nagasaki University)
Lipid scrambling on plasma membranes is an important phenomenon to change the asymmetric distribution of lipids in the lipid bilayer, resulting in exposure of lipids locating at the inner side of the membrane and allowing them to function as signaling molecules that interact with the extracellular environment. On the other hand, lipid scrambling in the organelle is an important process to equilibrate lipids synthesized at one side of the lipid bilayer and to transfer lipids to the luminal side for further lipid modification. Recently, the molecular mechanisms of these lipid-scrambling molecules and their physiological roles have been elucidated. In this symposium, researchers focusing on lipid scrambling on plasma membranes and organelles will gather to share knowledge and discuss future prospects and issues.
1S15m
Date:November 9th 9:00-11:00 Place: Room 15（131+132）
Commonality and diversity of phospho-signaling beyond species
organizer:
Kohsuke Takeda（Nagasaki University)
Taishi Umezawa（Tokyo University of Agriculture and Technology)
Motoyuki Ogawa（The University of Tokyo)
Yoshikatsu Matsubayashi（Nagoya University)
Mutsuhiro Takekawa（The University of Tokyo)
Taishi Umezawa（Tokyo University of Agriculture and Technology)
Taiki Baba（Nagasaki University）
Protein phosphorylation is a prototypical reversible post-translational modification that has long been regarded as a central subject in the signal transduction research. To comprehensively understand phospho-signaling, it is crucial to investigate both kinases and phosphatases and to explore general regulatory mechanisms, as well as novel biological regulations in individual species, by overlooking commonality and diversity of phospho-signaling beyond species. In fact, studies in a variety of model organisms have contributed a lot to the understandings of phospho-signaling. In this symposium, we will introduce the latest findings on phospho-signaling in animals and plants and provide an opportunity to reconsider the interest and importance of phospho-signaling and to discuss future directions in this area.
1S16m
Date:November 9th 9:00-11:00 Place: Room 16（133+134）
Regulatory mechanism of nervous system and immune system through intracellular organelle
organizer:
Michiko Shirane（Graduate School of Pharmaceutical Sciences, Nagoya City University)
Tatsuya Saitoh（Graduate School of Pharmaceutical Sciences, Osaka University)
Michiko Shirane（Graduate School of Pharmaceutical Sciences, Nagoya City University)
Tatsuya Saitoh（Graduate School of Pharmaceutical Sciences, Osaka University)
Shin-ichiroh Saitoh（The Institute of Medical Science, The University of Tokyo)
Kojiro Mukai（Graduate School of Life Sciences, Tohoku University)
Masataka Kunii（Graduate School of Medicine, Osaka University)
Seiji Watanabe（Research Institute of Environmental Medicine, Nagoya University)
Tatsuya Saitoh（Graduate School of Pharmaceutical Sciences, Osaka University)
Shin-ichiroh Saitoh（The Institute of Medical Science, The University of Tokyo)
Kojiro Mukai（Graduate School of Life Sciences, Tohoku University)
Masataka Kunii（Graduate School of Medicine, Osaka University)
Seiji Watanabe（Research Institute of Environmental Medicine, Nagoya University)
Intracellular organelles play an important role in various aspects of the regulation of physiological functions. Whereas the nervous system and the immune system interact with each other, which are inseparable to explain complex pathophysiological mechanisms. As an aside, the research field of neuroimmunology has been established. For example, it has been suggested that an enhanced immune response is associated with the pathological mechanisms of neurodegenerative and psychiatric disorders. Based on these backgrounds, this session will focus on the nervous system and the immune system to discuss the regulatory mechanism of homeostasis through intracellular organelles. We then would like to share the underlying mechanisms that are common to the nervous system and the immune system, or that connect them, which will lead to the development of the interdisciplinary research.
1S01a
Date:November 9th 13:20-14:50 Place: Room 1（Reception Hall）
The ideal way of the communities that connect young researchers
organizer:
Toya Yamamoto（The University of Tokyo）
Yusuke Kato（Japan Advanced Institute of Science and Technology）
Toya Yamamoto（The University of Tokyo）
Yusuke Kato（Japan Advanced Institute of Science and Technology）
Sota Inoue（Kyoto University）
In recent years, research meetings and researcher communities for young researchers have been formed. These communities are valuable not only for researchers in the same field but also as a place for exchange in different fields, and many young researchers may belong to some communities. Considering the current situation, the successful functioning and maturation of these communities will be indispensable for the future development of research. The “Young Researchers Society of Biochemistry” is an association of young researchers in the life sciences that has been active since 1958 under the auspices of the Japanese Biochemical Society, and has three main activities: the operation of “Summer School of Life Sciences”, “Cuvette Committee” and “Branch Activities”. The purpose of this symposium is to discuss the future of the young researchers’ community by using the Young Researchers Society of Biochemistry as an example.
1S01e
Date:November 9th 16:40-18:40 Place: Room 1（Reception Hall）
Structure-function relationships of membrane proteins toward understanding of their action mechanism
organizer:
Kazuhiro Abe（CeSPI, Nagoya University)
Haruo Ogawa（Graduate School of Pharmacy, Kyoto Universioty)
Takushi Shimomura（National Institute for Physiological Sciences)
Keiichi Okazaki（Institute for Molecular Science)
Takaharu Sakuragi（IFReC, Osaka University)
Keiichi Okazaki（Institute for Molecular Science)
Takaharu Sakuragi（IFReC, Osaka University)
Membrane proteins are responsible for the formation of the asymmetric distribution of substances/information across biological membranes, thus one of the important bases of living system. Because of their function, these membrane proteins are also important targets for drug development. On the basis of classical but established methods including molecular biology, biochemistry and physiology, recent innovative analytical methods such as cryo-electron microscopy and machine learning brings great advances in elucidating structure-function relationships of membrane proteins, as well as in understanding their relationship to biological functions and pathologies. In this symposium, we will introduce the latest findings of young researchers who are developing research to understand the mechanism of membrane protein function using structural information as a clue.
1S02e
Date:November 9th 16:40-18:40 Place: Room 2（141+142）
Medical Revolution with Mutlimodality
organizer:
Masatoshi Hagiwara（Graduate School of Medicine, Kyoto University)
Hiroyuki Sonoda（JCR Pharmaceuticals Co., Ltd.)
Masasothi Hagiwara（Graduate School of Medicine, Kyoto University)
Hiroyuki Sonoda（JCR Pharmaceuticals Co., Ltd.)
Hisataka Kobayashi（National Institutes of Health(NIH))
Takaaki Kobayashi（Aichi Medical School)
Hiroyuki Sonoda（JCR Pharmaceuticals Co., Ltd.)
Hisataka Kobayashi（National Institutes of Health(NIH))
Takaaki Kobayashi（Aichi Medical School)
Recently, we often hear the words “multimodal drug development”, which seem to be used with narrow definition, suggesting the shift from small chemicals to antibody and nucleotide drugs. However, the front of advanced medicine is now drastically movin forward because of wide range innovation in life sciences. We would like to share the updated informaion about the revolutional progress of multimodal medical inovation with members of JBS.
1S03e
Date:November 9th 16:40-18:40 Place: Room 3（International Conference Rooms）
Chronoproteinology
organizer:
Hikari Yoshitane（Tokyo Metropolitan Institute of Medical Science)
Kazuhiro Yagita（Kyoto Prefectural University of Medicine)
sponsor: Transformative Research Areas (B) "Chronoproteinology"
Takuya Matsuo（Nagoya University)
Koji Ode（The University of Tokyo)
Hiroshi Toda（Tsukuba University)
Hikari Yoshitane（Tokyo Metropolitan Institute of Medical Science)
Atsushi Mukaiyama（Institute for Molecular Science )
Shosei Yoshida（National Institute for Basic Biology)
Koji Ode（The University of Tokyo)
Hiroshi Toda（Tsukuba University)
Hikari Yoshitane（Tokyo Metropolitan Institute of Medical Science)
Atsushi Mukaiyama（Institute for Molecular Science )
Shosei Yoshida（National Institute for Basic Biology)
There are various time scales in biology such as longevity, seasonal responses, circadian rhythmicity, developmental processes, cell division cycles, and heartbeats. In other words, living organisms consists of different time scales. What are the mechanisms for measuring “time” that correspond to each event at different time scale? This symposium is co-organized with Transformative Research Areas (B) “Chronoproteinology”. We will focus on proteins responsible for molecular mechanisms that directly regulate time information. The physical properties and dynamics of proteins could generate “time” on various time scales as autonomous protein oscillators. The dynamics includes protein-protein interactions, post-translational modifications, enzymatic activities, and conformational changes.
1S04e
Date:November 9th 16:40-18:40 Place: Room 4（234）
Dysregulation of genome function as a mechanistic cause of human disease
organizer:
Yutaka Kondo（Division of Cancer Biology, Nagoya University Graduate School of Medicine)
Atsushi Kaneda（Department of Molecular Oncology, Graduate School of Medicine, Chiba University)
Noriko Saitoh（The Cancer Institute of JFCR)
Atsushi Kaneda（Department of Molecular Oncology, Graduate School of Medicine, Chiba University)
Daichi Inoue（Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe)
Naoko Hattori（Division of Epigenomics, National Cancer Center Research Institute)
Yutaka Kondo（Division of Cancer Biology, Nagoya University Graduate School of Medicine)
Atsushi Kaneda（Department of Molecular Oncology, Graduate School of Medicine, Chiba University)
Daichi Inoue（Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe)
Naoko Hattori（Division of Epigenomics, National Cancer Center Research Institute)
Yutaka Kondo（Division of Cancer Biology, Nagoya University Graduate School of Medicine)
An appropriate regulation of genome function is important in multiple biological processes. Epigenetic mechanism is widely accepted as a key player in transcriptional regulation. After transcription of RNA, alternative splicing of pre-mRNA increases genetic diversity. Biogenesis of a set of non-coding RNAs, including long non-coding RNA, is distinct from that of mRNAs and is linked with their specific functions in the genome regulation. Notably, these mechanisms dynamically interact each other and play a key role in regulation of cell function, dysregulation of which results in the development of human diseases. In this symposium, we discuss the novel aspects of control of genome function, such as functions in transcriptional, post-transcriptional and other modes of regulation, in human diseases.
1S05e
Date:November 9th 16:40-18:40 Place: Room 5（231）
New twists in autophagy-lysosome research
organizer:
Hitoshi Nakatogawa（School of Life Science and Technology, Tokyo Institute of Technology)
Shuhei Nakamura（Institute for Advanced Co-Creation Studies, Osaka University)
Hitoshi Nakatogawa（Tokyo Institute of Technology)
Yuko Fujioka（Institute of Microbial Chemistry)
Yoshikazu Johmura（The University of Tokyo)
Taeko Kobayashi（Kyoto University)
Nanobu Fujita（Tokyo Institute of Technology)
Shuhei Nakamura（Osaka University)
Yuko Fujioka（Institute of Microbial Chemistry)
Yoshikazu Johmura（The University of Tokyo)
Taeko Kobayashi（Kyoto University)
Nanobu Fujita（Tokyo Institute of Technology)
Shuhei Nakamura（Osaka University)
Autophagy is a collective term for pathways that degrade cells’ own components in lysosomes or vacuoles. Diverse pathways and selective substrates are now integrated as “multimode autophagy”, and the mechanisms, physiological roles, and inter-pathway interactions are under intense study, in which the importance of the understanding of the physical state of cytoplasmic proteins involved in autophagy induction or degraded via autophagy has been emerging. On the other hand, it has become clear that lysosomal degradation products and various components of lysosomes are actively involved in many biological phenomena such as development and aging, and that lysosomes act as a site of degradation and as a hub for various signal transductions. In this symposium, 6 researchers will present recent findings regarding autophagy and lysosomes, and the future development and potential of autophagy-lysosome research will be discussed.
1S06e
Date:November 9th 16:40-18:40 Place: Room 6（232+233）
Biochemical research using state-of-the-art mass spectrometry technology
organizer:
Yuki Sugiura（School of Medicine Department of Biochemistry, Keio University)
Yoshihiro Izumi（Research Center for Transomics Medicine Medical Institute of Bioregulation, Kyushu University)
Koji Atarashi（School of Medicine Department of Microbiology and Immunology, Keio University)
Michio Miyajima（Center for Integrative Medical Sciences (IMS) Laboratory for Mucosal Immunity, RIKEN)
Kosuke Nagata（Kyushu University）
Yuki Sugiura（School of Medicine Department of Biochemistry, Keio University)
More than 40 years ago, the mass spectrometer was a simple qualitative tool for identifying “what molecules are there”. It was an important technique in classical biochemical research to discover important enzymatic reactions and bioactive molecules. Today, proteomics and metabolomics using mass spectrometry have made it possible to obtain vast amounts of information in a very short time. However, in hypothesis-testing biochemical research, it is necessary to devise ways to utilize the vast amount of information obtained from omics measurements. Simply drowning in a sea of data will make it difficult to find the essential factors that explain physiological phenomena.Despite this background, several leading researchers have successfully used omics measurements as a tool for biochemical research to identify bioactive molecules that can explain individual phenotypic systems and cell types with specialized metabolic pathways. In addition to these success stories, this session will introduce mass spectrometry imaging to add spatial information to omics measurements and discuss basic and advanced applications of mass spectrometry.
1S07e
Date:November 9th 16:40-18:40 Place: Room 7（224）
Biochemical approaches for kidney diseases
organizer:
Kengo Furuichi（Kanazawa Medical University Department of Nephrology)
Mako Yamahara（Department of Medicine, Shiga University of Medical Science)
Mako Yamahara（Department of Medicine, Shiga University of Medical Science)
Sho Hasegawa（Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo, Graduate School of Medicine)
Kohei Uchimura（Division of Nephrology, Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi)
Motoko Yanagida（Department of Nephrology, Graduate School of Medicine, Kyoto University)
Yutaro Mori（Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)
Kenji Osafune（Center for iPS Cell Research and Application (CiRA), Kyoto University)
The kidney has various functions such as electrolyte maintenance, acid-base equilibrium, erythrocyte metabolism, or bone metabolism, and is an important organ for maintaining systemic homeostasis. These kidney functions are impaired by abnormal gene expression, metabolism, regeneration, inflammation and immune system. Recent advanced biochemical techniques contribute to revealing the mechanisms of kidney diseases and discovering new drugs. In this symposium, we would like to introduce the latest research progress on kidney diseases using biochemical techniques. The Japanese Society of Nephrology encourage to expand renal research consortiums. This symposium is conducted to make the member of the Japanese Biochemical Society interest in research for kidney disease.
1S08e
Date:November 9th 16:40-18:40 Place: Room 8（221）
Toward Innovation in Glycobiology
organizer:
Motoi Kanagawa（Ehime University Graduate School of Medicine)
Hideyuki Takeuchi（University of Shizuoka School of Pharmaceutical Sciences)
Akihiko Nakono（RIKEN Center for Advanced Photonics)
Katsunori Tanaka（RIKEN/Tokyo Institute of Technology)
Yoshiki Narimatsu（Copenhagen University, Copenhagen Center for Glycomics)
Akira Minami（School of Pharmaceutical Sciences, University of Shizuoka)
Motoi Kanagawa（Ehime University Graduate School of Medicine)
Katsunori Tanaka（RIKEN/Tokyo Institute of Technology)
Yoshiki Narimatsu（Copenhagen University, Copenhagen Center for Glycomics)
Akira Minami（School of Pharmaceutical Sciences, University of Shizuoka)
Motoi Kanagawa（Ehime University Graduate School of Medicine)
Glycans have been called the “third life chain” after nucleic acids and proteins, or the “face of the cell,” and their importance in living organisms has been widely recognized. Glycobiologists in Japan have made world-leading contributions to the accumulation of basic scientific knowledge, as exemplified by the discovery of glycosyltransferases, and the construction of analytical technologies such as mass spectrometry and databases. Although there are still many unanswered questions about the structure and function of glycans and, above all, the mechanisms of biosynthesis and degradation of glycosylation, there are growing expectations for the potential of glycobiology in both academic and applied sciences. At the same time, breakthroughs are required to elucidate the diversity of glycans and their complex modification patterns. In this symposium, we would like to introduce innovative researches based on the structure and function of glycans and discuss the cell biological principles such as modification mechanisms that are necessary for glycans to exert their physiological functions.
1S09e
Date:November 9th 16:40-18:40 Place: Room 9（222）
Regulation of nutrient acquisition and growth via long-distance signaling in plants
organizer:
Hitoshi Sakakibara（Nagoya University)
Takushi Hachiya（Shimane University)
Hitoshi Sakakibara（Nagoya University)
Shoji Segami（National Institute of Basic Biology)
Nao Okuma（National Institute of Basic Biology)
Yuri Ohkubo（Nagoya university)
Takushi Hachiya（Shimane University)
Shoji Segami（National Institute of Basic Biology)
Nao Okuma（National Institute of Basic Biology)
Yuri Ohkubo（Nagoya university)
Takushi Hachiya（Shimane University)
Nutrient elements are often inadequately supplied and heterogeneously distributed in the soil, and thus, limiting plant growth. To acquire the commonly-deficient nutrients, plants have developed various systems including high-affinity transporters for nutrient uptake, root nodule symbiosis, and insectivorous leaves. Recent studies indicate that the long-distance signals such as the phytohormones, peptides, miRNAs, and action potential move between tissues and organs, which in turn, drive the above systems for nutrient acquisition. Moreover, some of the long-distance signals fine-tune plant growth and development depending on the internal and external levels of the nutrients. In the present symposium, we will introduce recent advances on the long-distance signals and their regulatory mechanisms at the molecular scale to optimize the nutrient acquisition and growth, and discuss issues in the future.
1S10e
Date:November 9th 16:40-18:40 Place: Room 10（223）
Universality and diversity of glycosylation
organizer:
Hiroto Hirayama（Glycometabolic Biochemistry Laboratory, RIKEN)
Morihisa Fujita（Institute for Glyco-core Research (iGCORE), Gifu University)
Hiroto Hirayama（Glycometabolic Biochemistry Laboratory, RIKEN)
Yoichiro Harada（Osaka International Cancer Institute)
Daisuke Kohda（Kyushu University Medical Institute of Bioregulation)
Xiao-Dong Gao（School of Biotechnology, Jiangnan University)
Yoichi Noda （Department of Biotechnology, The University of Tokyo, CRIIM)
Takuji Oka（Faculty of Biotechnology and Life Science, Department of Biotechnology and Life Science, Sojo University)
Yoichiro Harada（Osaka International Cancer Institute)
Daisuke Kohda（Kyushu University Medical Institute of Bioregulation)
Xiao-Dong Gao（School of Biotechnology, Jiangnan University)
Yoichi Noda （Department of Biotechnology, The University of Tokyo, CRIIM)
Takuji Oka（Faculty of Biotechnology and Life Science, Department of Biotechnology and Life Science, Sojo University)
Glycosylation is one of the “universal” post-translational modifications of proteins conserved in whole kingdoms (i.e., bacteria, archaea, and eukaryote) and plays pivotal roles not only in their physicochemical properties such as solubility and stability but in fundamental processes that are essential for biological activities such as targeting of secretory proteins, cell-cell interaction, and signal transduction. On the other hand, glycans are known to have structural “diversity” among species. To well understand the biological meanings of the diversity of the glycan structures, it is indispensable to clarify the correlation between the unique glycan structures and their functions. In this symposium, recent research progress on biosynthesis as well as the biological functions of the glycans in a variety of species, ranging from microorganisms to mammals, will be introduced.
1S11e
Date:November 9th 16:40-18:40 Place: Room 11（211）
Advanced biochemistry of disease pathophysiology revealing “life-aging-disease-death", ~nuclear and mitochondria signal~
organizer:
Tomoaki Tanaka（Chiba University)
Satoshi Inoue（Tokyo Metropolitan Institute of Gerontology )
Kazuyuki Yamagata（Chiba University )
Kazuhiro Ikeda（Saitama Medical University )
Takashi Ito（Nagasaki University )
Hideaki Matsui（Niigata University )
Toshimori Kitami（RIKEN Center for Integrative Medical Sciences)
Kazuhiro Ikeda（Saitama Medical University )
Takashi Ito（Nagasaki University )
Hideaki Matsui（Niigata University )
Toshimori Kitami（RIKEN Center for Integrative Medical Sciences)
The development of single-cell analysis and cell-cell interaction analysis technologies, coupling to the advancement of proteomics and data-science, is opening up new perspectives on the pathogenesis of “life-aging-disease-death”, such as disease biology of liquid-liquid phase separation and inter-organ single-cell networks. In particular, life, lifespan, and aging signals are interestingly integrated into nuclear events and mitochondrial metabolic signals such as transcription, translation, epigenomic regulatory mechanisms, oxidative stress, nutrition, and metabolism. In this symposium, with the theme of “Novel insights into life-aging-disease-death from cutting-edge biochemistry,” we will introduce the pioneering studies that have opened up the relationship with disease pathophysiology through new approaches such as complex analysis, single cell analysis, and multi-omics analysis. Focusing on the nuclear and mitochondria, we would like to deepen our discussion on the new biochemistry of “life-aging-disease-death” including future developments and possibilities.
1S12e
Date:November 9th 16:40-18:40 Place: Room 12（212）
Maintenance of homeostasis and the development of diseases regulated by brain-peripheral organ interaction
organizer:
Ayaka Ito（Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine/Institute for Advanced Research, Nagoya University)
Naoya Kataoka（Department of Integrative Physiology, Nagoya University Graduate School of Medicine/ Institute for Advanced Research, Nagoya University)
sponsor: Nagoya University program for promoting the enhancement of research universities, Young Researcher Unit.
Naoya Kataoka（Department of Integrative Physiology, Nagoya University Graduate School of Medicine/ Institute for Advanced Research, Nagoya University)
Satoshi Koba（Division of Integrative Physiology, Faculty of Medicine, Tottori University )
Kazuhiro Suzuki（Lab of Immune Response Dynamics, IFReC, Osaka University)
Hiroshi Inoue（Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative/Department of Physiology and Metabolism, Graduate School of Medical Sciences, Kanazawa University)
Satoshi Koba（Division of Integrative Physiology, Faculty of Medicine, Tottori University )
Kazuhiro Suzuki（Lab of Immune Response Dynamics, IFReC, Osaka University)
Hiroshi Inoue（Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative/Department of Physiology and Metabolism, Graduate School of Medical Sciences, Kanazawa University)
Proper communication between brain and peripheral system plays critical roles in homeostasis and diseases. Psychological stress induces various physiological responses by activating the sympathetic nervous system. On the contrary, it has been suggested that the dysregulation of peripheral physiological functions impair autonomic nervous system, which in turn aggravate various diseases. Therefore, understanding the mechanisms underlying neural-peripheral crosstalk is important to elucidate the pathogenesis of diseases, and which has a significant impact on therapeutic strategy. This symposium will highlight the latest research on neural circuits that control thermogenic and cardiovascular functions, neuroimmune communication and neural regulation of metabolic diseases such as cardiovascular diseases and diabetes.
1S13e
Date:November 9th 16:40-18:40 Place: Room 13（431）
Biochemistry of RNA binding proteins: the active roles in physiological condition and neurological diseases
organizer:
Koji Yamanaka（Nagoya University)
Yoshitaka Nagai（Kindai University)
Tetsuro Hirose（Osaka University)
Masahiro Fujii（Niigata University)
Yoshitaka Nagai（Kindai University)
Koji Yamanaka（Nagoya University)
Masahiro Fujii（Niigata University)
Yoshitaka Nagai（Kindai University)
Koji Yamanaka（Nagoya University)
RNA binding proteins (RBPs) have many roles in gene expression and regulation of cell function. Recently, the physiological and pathological roles of RBPs have been elucidated including liquid-liquid phase separation. In this symposium, the cutting edge knowledge for the multi-functional roles of RBPs in health and neurodegenerative disease will be shared and the future direction of this field will also be discussed.
1S14e
Date:November 9th 16:40-18:40 Place: Room 14（432）
Novel function of lysophospholipid mediators
organizer:
Junken Aoki（Graduate School of Pharmaceutical Sciences, University of Tokyo)
Satoshi Ishii（Graduate School of Pharmaceutical Sciences, Akita University)
Daisuke Yasuda（Graduate School of Pharmaceutical Sciences, Akita University)
Kazuhito Naka（Research Institute for Radiation Biology and Medicine, Hiroshima University)
Ai Kotani（Department of Medicine, Tokai University)
Yoshitaka Taketomi（Graduate School of Medicine)
Junken Aoki（Graduate School of Pharmaceutical Sciences)
Kazuhito Naka（Research Institute for Radiation Biology and Medicine, Hiroshima University)
Ai Kotani（Department of Medicine, Tokai University)
Yoshitaka Taketomi（Graduate School of Medicine)
Junken Aoki（Graduate School of Pharmaceutical Sciences)
Lysophospholipids are phospholipids with a single fatty acid present in the blood and tissues. They are produced during inflammation and tissue damage. To date, less than twenty G-protein-coupled receptors (GPCRs) have been identified that recognize the whole molecules of each lysophospholipid including polar head and fatty acid portions. Japanese researchers have made a significant contribution to this research field by identifying lysophospholipid receptors and enzymes and the following analyses of knockout mice of these molecules. In this symposium, we will summarize the latest topics on the new functions of lysophospholipid mediators through the study of receptors, producing enzymes, and producing sources, focusing on their function in angiogenesis, hematopoietic stem cell/hematopoietic cell differentiation, and cancer.
1S15e
Date:November 9th 16:40-18:40 Place: Room 15（131+132）
Muti-layered analyses to decode complexity of biological phenomena and signal transduction
organizer:
Asuka Inoue（Graduate School of Pharmaceutical Sciences, Tohoku University)
Tsuyoshi Saitoh（International Institute for Integrative Sleep Medicine, University of Tsukuba)
Asuka Inoue（Graduate School of Pharmaceutical Sciences, Tohoku University)
Tsuyoshi Saitoh（International Institute for Integrative Sleep Medicine, University of Tsukuba)
Katsuyasu Sakurai（International Institute for Integrative Sleep Medicine, University of Tsukuba)
Ryoji Suno（Kansai Medical University)
Tsuyoshi Saitoh（International Institute for Integrative Sleep Medicine, University of Tsukuba)
Katsuyasu Sakurai（International Institute for Integrative Sleep Medicine, University of Tsukuba)
Ryoji Suno（Kansai Medical University)
In the field of receptor biology, including GPCRs, receptor activity is often simplified as a on-off state. Recently, a concept of bias signaling has been focused on as a way to regulate complex receptor signaling. In this symposium, using the opioid receptors in the nervous system, we will explain advances in technologies including ligand, structural, cellular, and individual levels and discuss how to integrate these multi-layered researches to clarify the complex neural circuits involving drug efficacy and side effects. The speakers are from the KAKENHI Grant-in-Aid for Transformative Research Areas (B) and will present their ongoing joint projects to decode signaling.
1S16e
Date:November 9th 16:40-18:40 Place: Room 16（133+134）
The functional cooperation of organelle reveals the real-pictures of life phenomena.
organizer:
Atsushi Saito（Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University)
Akiko K. Satoh（Program of Life and environmental Science, Graduate School of Integral Science for Life, Hiroshima University)
sponsor:
Core Research for Organelle Diseases in Hiroshima University (the MEXT program for promoting the enhancement of research universities, Japan)
Akiko K. Satoh（Program of Life and environmental Science, Graduate School of Integral Science for Life, Hiroshima University)
Seiichi Koike（Program of Life and Material chemistry, Graduate School of Science and Engineering, Toyama University)
Atsushi Saito（Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University)
Hiromi Tamada（Functional Anatomy and Neuroscience, Graduate School of Medicine, Nagoya University)
Takuro Tojima（RIKEN Center for Advanced Photonics)
Masatsugu Miyara（Department of Neurochemistry and Environmental Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University)
Seiichi Koike（Program of Life and Material chemistry, Graduate School of Science and Engineering, Toyama University)
Atsushi Saito（Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University)
Hiromi Tamada（Functional Anatomy and Neuroscience, Graduate School of Medicine, Nagoya University)
Takuro Tojima（RIKEN Center for Advanced Photonics)
Masatsugu Miyara（Department of Neurochemistry and Environmental Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University)
Organelles are segmented compartment by lipid membranes. Abundant studies have elucidated the unique biochemical reactions and functions in lumens of each organelle. Meanwhile, organelles form specific areas through the crosstalk of substances and the direct contact among their membranes, that enable to maximize cellular functions. We introduce the latest technologies including SCLIM and FIB/SEM, that allow elaborate surveillances of local regions in organelles. We also report the late-breaking findings to approach the real-picture of life phenomenon shaped by the communication and the substance transfer among organelles. Additionally, the discussion regarding molecular mechanisms linking the disturbances of these machineries with the pathogenesis is included in the aim of this symposium.
2S02m
Date:November 10th 9:00-11:00 Place: Room 2（141+142）
Glial decoding of brain functions
organizer:
Hiroaki WAKE（Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine)
Schuichi Koizumi（Dept Neuropharmacol, 2GLIA Center, Grad Sch Med, Univ Yamanashi)
Hiroaki WAKE（Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine)
Ryuta Koyama（Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Schuichi Koizumi（1Dept Neuropharmacol, 2GLIA Center, Grad Sch Med, Univ Yamanashi)
Shigeo Okabe（Department of Cellular Neurobiology, Graduate School of Medicine, the University of Tokyo)
Ryuta Koyama（Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Schuichi Koizumi（1Dept Neuropharmacol, 2GLIA Center, Grad Sch Med, Univ Yamanashi)
Shigeo Okabe（Department of Cellular Neurobiology, Graduate School of Medicine, the University of Tokyo)
The development of optical technology allow us to read out cell structures, cell-cell interactions, and their dynamics and functions in living organisms by visualizing them in in vivo that lead the extraction of physiological functional responses and changes in pathological conditions. Especially in the nervous system, two-photon microscopy, super-resolution microscope and electron microscope has revealed the dynamics and functional responses of the nervous system, and has led to active research on changes in the brain environment, brain signals, and how the brain detects changes in the external world, and the relationship between these factors. In this symposium, we would like to discuss the research that four researchers have conducted by using various readout techniques to observe coding in brain functions by glial cells.
2S03m
Date:November 10th 9:00-11:00 Place: Room 3（International Conference Rooms）
Novel approaches to analyze membrane proteins in dynamic cellular processes
organizer:
Tadato Ban（Institute of Life Science, Kurume University)
Takumi Koshiba（Department of Chemistry, Faculty of Science, Fukuoka University)
Ken Daniel Inaoka（School of Tropical Medicine and Global Health, Nagasaki University, )
Kenichi Morigaki（Biosignal Research Center, Kobe University)
Atsushi Shimada（Medical Institute of Bioregulation, Kyushu University)
Masashi Tachikawa（Institute for Frontier Life and Medical Sciences, Kyoto University)
Tadato Ban（Institute of Life Science, Kurume University)
Kenichi Morigaki（Biosignal Research Center, Kobe University)
Atsushi Shimada（Medical Institute of Bioregulation, Kyushu University)
Masashi Tachikawa（Institute for Frontier Life and Medical Sciences, Kyoto University)
Tadato Ban（Institute of Life Science, Kurume University)
Membrane proteins play a central role in intracellular processes, such as signaling, energy production, and membrane fusion. Therefore, multiple information on the structural changes, assembly states and distribution of membrane proteins in biological membranes are essential for understanding spatio-temporal controlled intracellular processes. Since the distribution of lipid molecules and their interactions with membrane proteins are also important factors, it has become essential to coordinate multifaceted analyses such as the construction of artificial lipid bilayers and mathematical modeling. In this symposium, we invite experimental and theoretical researchers and discuss the regulatory mechanisms of membrane protein activity and distribution in the plasma and organelle membranes.
2S04m
Date:November 10th 9:00-11:00 Place: Room 4（234）
A whole new world with new horizons to pursue: glycation in food and medical sciences
organizer:
Motoko Ohata（College of Bioresource Sciences, Nihon University)
Reiko Inagi（Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo, Graduate School of Medicine)
Motoko Ohata（College of Bioresource Sciences, Nihon University)
Yuri Nomi（Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences)
Melinda Coughlan（Glycation, Nutrition & Metabolism Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University)
Ai Harashima（Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences)
Kensei Taguchi（Division of Nephrology, Kurume University School of Medicine)
Yuri Nomi（Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences)
Melinda Coughlan（Glycation, Nutrition & Metabolism Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University)
Ai Harashima（Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences)
Kensei Taguchi（Division of Nephrology, Kurume University School of Medicine)
In food science, protein modification by glycation plays an important role in producing browning compounds and odors of foods, and glycation research has improved the quality and preference of food. Further, it is highlighted that food glycation leads to development of novel functional foods. Meanwhile, in medical science, overwhelming glycation causes derangement of protein hemostasis associated with pathogenic cellular signals, which develop various diseases. The recently accumulated evidence further demonstrated that highly glycated food intake affects interorgan communication: glycated food intake induces kidney damage via intestine-derived inflammation. Glycation intricately links food and medical sciences. In this session, we, including a speaker from a foreign country, will summarize the updated glycation research in both fields and discuss the future perspective of food and medical glycation.
2S05m
Date:November 10th 9:00-11:00 Place: Room 5（231）
Cell cycle dysregulation in cancer
organizer:
Midori Shimada（Yamaguchi University, Joint Graduate School of Veterinary Medicine)
Yoichiro Tamori（Kyoto University, Graduate School of Medicine)
Atsushi Shibata（Gunma University, Gunma University Initiative for Advanced Research)
Shin-ichiro Takebayashi（Mie University, Graduate School of Bioresources)
Ryota Uehara（Hokkaido University, Faculty of Advanced Life Science)
Midori Shimada（Yamaguchi University, Joint Graduate School of Veterinary Medicine)
Yoichiro Tamori（Kyoto University, Graduate School of Medicine)
Shin-ichiro Takebayashi（Mie University, Graduate School of Bioresources)
Ryota Uehara（Hokkaido University, Faculty of Advanced Life Science)
Midori Shimada（Yamaguchi University, Joint Graduate School of Veterinary Medicine)
Yoichiro Tamori（Kyoto University, Graduate School of Medicine)
Cell division plays a fundamental role in biological phenomena, and the dysregulation of this system is known to be involved in various diseases such as cancer development and malignant transformation. In order to maintain genome stability during cell division, accurate DNA replication, DNA repair, and the maintenance of chromosome ploidy are essential. An integrated understanding of these various maintenance systems is necessary to progress cancer research. In this symposium, we will invite researchers who have introduced technological innovations and comprehensive analyses, such as single-cell genome copy number analysis technology and ultra-high-resolution imaging, to explore the reality of homeostasis in multicellular organisms and discuss new targets for cancer therapy based on the elucidation of molecular mechanisms.
2S06m
Date:November 10th 9:00-11:00 Place: Room 6（232+233）
New approaches to protein-protein interaction analysis using proximity-dependent biotinylation enzymes
organizer:
Tatsuya Sawasaki（PROS, Ehime University)
Hidetaka Kosako（IAMS, Tokushima University)
sponsor: PRiME (PROS Joint Usage/Research Program for Protein Interactome）
Tatsuya Sawasaki（PROS, Ehime Univ.)
Ryo Morishita（CellFree Sciences Co., Ltd.)
Yuka Li（Grd Schl of Pharm Sci, Kyoto Univ)
Hidetaka Kosako（IAMS, Tokushima Univ.)
Satoshi Yamanaka（PROS, Ehime Univ.)
Kohei Kawaguchi（IIR, TokyoTech)
Ichiro Taniuchi（RIKEN IMS)
Ryo Morishita（CellFree Sciences Co., Ltd.)
Yuka Li（Grd Schl of Pharm Sci, Kyoto Univ)
Hidetaka Kosako（IAMS, Tokushima Univ.)
Satoshi Yamanaka（PROS, Ehime Univ.)
Kohei Kawaguchi（IIR, TokyoTech)
Ichiro Taniuchi（RIKEN IMS)
The formation of protein complexes is one of the mechanisms that regulate protein functions. Therefore, the identification and analysis of interacting proteins in vivo is important for better understanding of target proteins. Recently, the BioID method, in which biotinylation enzyme is fused to the target protein and proximal proteins are identified by biotinylation, has been developed, and the enzymes have been improved. In this symposium, we will mainly introduce four BioID technologies: 1) analyzing biotinylated peptides, 2) screening interacting proteins using protein arrays, 3) identifying and analyzing interacting proteins in cells and organisms, and 4) analyzing drug-dependent interactions in cells. Then we would like to share the current status and future development of the BioID method.
2S07m
Date:November 10th 9:00-11:00 Place: Room 7（224）
Biology of Lipid Diversity
organizer:
Makoto Arita（Keio University Faculty of Pharmacy, RIKEN Center for Integrative Medical Sciences)
Tomohiko Taguchi（Graduate School of Life Sciences, Tohoku University)
Makoto Arita（Keio University Faculty of Pharmacy, RIKEN Center for Integrative Medical Sciences)
Fumika Mi-ichi （ Faculty of Medicine, Saga University)
Koichiro Hirosawa（iGCORE, Gifu university)
Kuniyuki Kano（Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Hyeon-Cheol Lee-Okada（Juntendo University)
Lipids are biomolecules that play roles in biological membranes, serving as energy sources, signaling molecules and their precursors. The properties of lipids can be divided into two categories: those with bioactivity as single molecules and those involved in platform formation as molecular assemblies. It is important to understand how these lipids are recognized and utilized in vivo at the molecular level. Moreover, since abnormal lipid metabolism is often a background factor for diseases, and many lipid molecules contain bioactivity, it may lead to the drug discovery and medical applications such as early diagnosis and treatment. In this symposium, we will discuss the biological significance of lipid diversity at the cellular and tissue levels.
2S08m
Date:November 10th 9:00-11:00 Place: Room 8（221）
Self-recognition by the immune system and its physiological implications
organizer:
Sho Yamasaki（Osaka Unversity)
Koji Yasutomo（Tokushima University)
Shohei Hori（The University of Tokyo)
Motoko Kimura（Chiba University)
Kenichi Asano（Tokyo University of Pharmacy and Life Science)
Yoshihiro Izumi（Kyushu University)
Katsumori Segawa（Tokyo Medical and Dental University)
Seth Masters（WEHI)
Motoko Kimura（Chiba University)
Kenichi Asano（Tokyo University of Pharmacy and Life Science)
Yoshihiro Izumi（Kyushu University)
Katsumori Segawa（Tokyo Medical and Dental University)
Seth Masters（WEHI)
It has been thought that the immune system is a biological system that recognizes and eliminates non-self pathogens. However, it is virtually impossible for the immune system to recognize all unknown non-self pathogens, and there is still no rational explanation for its universal ability to deal with a myriad of foreign substances. Recently, it has become clear that not only acquired immune receptors but also innate immune sensors and many sensor-like molecules of unknown function weakly recognize self components. Multiple sensor molecules recognize a wide range of self-molecules to form sensing network, and immune system may detect objects that distort the equilibrium of this self-recognition network as “foreign substances”. In this symposium, six outstanding researchers who have been promoting pioneering research in this field will present their latest findings, providing an opportunity to redefine self-recognition by the immune system and its biological principle.
2S09m
Date:November 10th 9:00-11:00 Place: Room 9（222）
Frontiers in Regulation of Chromosome Function by Non-genomic information
organizer:
Atsuya Nishiyama（The Institute of Medical Science, The University of Tokyo)
Kyohei Arita（Graduate School of Medical Life Science, Yokohama City University)
Akihisa Osakabe（Department of Biological Sciences, The University of Tokyo/JST PRESTO)
Yusuke Kishi（Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Masato Kanemaki（Department of Chromosome Science, National Institute of Genetics)
Toru Sengoku（Graduate School of Medicine, Yokohama City University)
Kyohei Arita（Graduate School of Medical Life Science, Yokohama City University)
Atsuya Nishiyama（The Institute of Medical Science, The University of Tokyo)
Yusuke Kishi（Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Masato Kanemaki（Department of Chromosome Science, National Institute of Genetics)
Toru Sengoku（Graduate School of Medicine, Yokohama City University)
Kyohei Arita（Graduate School of Medical Life Science, Yokohama City University)
Atsuya Nishiyama（The Institute of Medical Science, The University of Tokyo)
Epigenetics and genetics are intricately linked, playing a key role invarious chromosomal events. DNA methylation, histone modifications,and chromatin higher-order structure are considered to play afundamental function in epigenetic regulation. This symposium bringstogether cutting-edge researchers from diverse fields, includingbiochemistry, structural biology, genetics, plant biology, anddevelopmental biology. We will discuss recent discoveries at the frontiersof chromatin fields to explore the emerging connection betweenepigenetics and genetics, with a particular focus on epigenetic andgenetic inheritance, gene expression, and cellular differentiation. Thissymposium aims to fuel further progress in these important topics
2S10m
Date:November 10th 9:00-11:00 Place: Room 10（223）
Complexity in Dementia: Toward a Better Understanding and Intervention
organizer:
Masataka Kikuchi（Osaka University)
Michiko Sekiya（National Center for Geriatrics and Gerontology)
Kensaku Kasuga（Niigata University)
Makoto Michikawa（Nagoya City University)
Haruhisa Inoue（Kyoto University)
Michiko Sekiya（National Center for Geriatrics and Gerontology)
Masataka Kikuchi（Osaka University)
Makoto Michikawa（Nagoya City University)
Haruhisa Inoue（Kyoto University)
Michiko Sekiya（National Center for Geriatrics and Gerontology)
Masataka Kikuchi（Osaka University)
A cure for the disease is a long-held desire for many patients. However, the underlying mechanisms of Alzheimer’s disease are still not fully understood 120 years after the first case was identified. In this symposium, we will discuss the following topics: biomarker research, which aims to understand the “complexity of pathology” such as various background pathologies and differences in lesions among brain regions, and to achieve highly accurate differentiation and diagnosis; iPS technology-based research, which aims to overcome the “complexity associated with aging” and to elucidate the mechanisms; and single-cell research, which aims to understand the “complexity of cell types” where various cell types in the brain cross-talk.
2S11m
Date:November 10th 9:00-11:00 Place: Room 11（211）
The ways to study our membrane transport proteins 2022
organizer:
Shushi Nagamori（The Jikei University of Medicine)
Tappei Takada（ The University of Tokyo Hospital)
Yuji Hara（University of Shizuoka)
Koichi Nakajo（Jichi Medical University)
Junko Kurokawa（University of Shizuoka)
Pattama Wiriyasermkul（The Jikei University of Medicine)
Tappei Takada（ The University of Tokyo Hospital)
Koichi Nakajo（Jichi Medical University)
Junko Kurokawa（University of Shizuoka)
Pattama Wiriyasermkul（The Jikei University of Medicine)
Tappei Takada（ The University of Tokyo Hospital)
Life is sustained by the disequilibrium of substances across biological membranes generated by membrane transport proteins, such as transporters, pumps, and channels. Although there are several hundred of membrane transport proteins in the human body, many of them are yet orphans. Even the physiological functions of “known” proteins have not been fully elucidated. We have studied membrane transport proteins based on biochemistry with techniques from various fields. For example, the molecular mechanisms of membrane transport have been clarified by the remarkable progress in structural biology. The physiological functions have been elucidated by using genetically modified animals or human organoids, which are getting relatively easy, and comprehensive omics analysis. In this symposium, we would like to discuss the further development of “Makuyusou-gaku” with not only biochemists but also researchers who have been studying membrane transport proteins based on physiology, pharmacology, etc
2S12m
Date:November 10th 9:00-11:00 Place: Room 12（212）
A dynamic concept of body water homeostasis may bring about a paradigm shift in our understanding of “salt" and “water" regulation
organizer:
Isao Naguro（The University of Tokyo)
Kento Kitada（Kagawa University)
Isao Naguro（The University of Tokyo)
Kento Kitada（Kagawa University)
Jens Titze（Duke-NUS Medical School)
Kaoru Minegishi（Yokohama City University)
Jonathan Jantsch（Institute of Clinical Microbiology and Hygiene, University HospitalRegensburg)
Takeshi Hiyama（Okayama University)
Kento Kitada（Kagawa University)
Jens Titze（Duke-NUS Medical School)
Kaoru Minegishi（Yokohama City University)
Jonathan Jantsch（Institute of Clinical Microbiology and Hygiene, University HospitalRegensburg)
Takeshi Hiyama（Okayama University)
It is well known that body salt and fluid homeostasis is systemically controlled by the kidneys. However, recent technologies such as 23Na-MRI revealed that Na content in the tissues is regulated independently of plasma Na concentration and that high Na accumulates locally in areas of inflammation and/or cancer. The Na concentration in these microenvironments regulates several specific proteins and influences metabolism, blood pressure, and immune system responses via osmotic pressure and reprogramming of immune cells. Thus, a new concept has emerged that concerted action of multiple organs (the kidney, liver, skin, nervous system etc.) is key for maintaining body salt and fluid regulation. In this symposium, we would like to share and discuss the paradigm shift of salt and water regulation with worldwide top-runners in the field.
2S13m
Date:November 10th 9:00-11:00 Place: Room 13（431）
An attraction for interdisciplinary research upgrading the existing model in the life science
organizer:
Tsuyoshi Ikura（Laboratory of Chromatin Regulatory Network, Radiation Biology Center, Graduate School of Biostudies ,Kyoto University)
Itaru Imayoshi（Laboratory of Brain Development and Regeneration, The Graduate School of Biostudies, Kyoto University)
Itaru Imayoshi（Laboratory of Brain Development and Regeneration, The Graduate School of Biostudies, Kyoto University)
Yuichi Wakamoto（Graduate School of Arts and Sciences, The University of Tokyo)
Takuma Shiraki（Kindai University, BOST)
Tsuyoshi Ikura（Laboratory of Chromatin Regulatory Network, Radiation Biology Center, Graduate School of Biostudies ,Kyoto University)
Yuichi Wakamoto（Graduate School of Arts and Sciences, The University of Tokyo)
Takuma Shiraki（Kindai University, BOST)
Tsuyoshi Ikura（Laboratory of Chromatin Regulatory Network, Radiation Biology Center, Graduate School of Biostudies ,Kyoto University)
Recent advances in biomathematics have highlighted the importance of interdisciplinary research between existing biochemical analyses and mathematical approach. One of the most exciting aspects of interdisciplinary research is to resolve discrepancies between experimental results and existing models through interaction between different fields. In this symposium, we will present our experiences in updating existing models by elucidating the significance of spatiotemporal control of these dynamic molecular responses such as oscillation of gene expression, molecular fluctuation and their variations, using mathematical statistics or development of devices with optical control, and discuss the future prospects of interdisciplinary research in the life science.
2S14m
Date:November 10th 9:00-11:00 Place: Room 14（432）
Interdisciplinary Frontier of Biochemistry Pioneered by Young Researchers
organizer:
Atsushi Miyashita（Teikyo University Institute of Medical Mycology)
Masaki Ishii（Musashino University)
Atsushi Miyashita（Teikyo University)
Yohei Hayashi（Tohoku University)
Yoshinori Inagaki（The University of Tokyo)
Shinya Ohata（Musashino University)
Yasuhiko Matsumoto（Meiji Pharmaceutical University)
Shinya Miyazaki（Nagasaki University)
Yohei Hayashi（Tohoku University)
Yoshinori Inagaki（The University of Tokyo)
Shinya Ohata（Musashino University)
Yasuhiko Matsumoto（Meiji Pharmaceutical University)
Shinya Miyazaki（Nagasaki University)
Bioscience has made remarkable progress over the past century by integrating concepts such as self and non-self, internal and external, and normal and abnormal into a unified understanding at the molecular level. Biochemistry is one of the powerful approaches to understand these concepts at the molecular level. Our molecular understanding of life, supported by biochemical insights, has evolved in a variety of ways that have led to the elucidation of more universal principles of life, new approaches to disease, and the generation of new hypotheses. Molecular understanding of basic biological phenomena, such as the formation of cellular and tissue identities during development and differentiation, and the discrimination of self and non-self by the immune system to eliminate foreign substances and cancer, are good examples. In this symposium, we will invite early and mid-career researchers who are active in a variety of basic and clinical research fields, and look forward to a lively discussion on the new frontiers opened up by biochemistry in a wide range of research areas such as development, differentiation, infection, immunity, and cancer.
2S15m
Date:November 10th 9:00-11:00 Place: Room 15（131+132）
Life Science Innovation Driven by Supersulfide Biology
organizer:
Motohiro Nishida（Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University)
Hozumi Motohashi（Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University)
Hozumi Motohashi（Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University)
Motohiro Nishida（Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University)
Tomohiro Sawa（Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University)
Michito Yoshizawa（Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology)
Kei Wada（Department of Medical Sciences, University of Miyazaki)
Kenjiro Hanaoka（Graduate School of Pharmaceutical Sciences, Keio University)
Motohiro Nishida（Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University)
Tomohiro Sawa（Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University)
Michito Yoshizawa（Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology)
Kei Wada（Department of Medical Sciences, University of Miyazaki)
Kenjiro Hanaoka（Graduate School of Pharmaceutical Sciences, Keio University)
Supersulfides, in which sulfur is linearly linked, is abundantly produced in our body as a universal life element, and has been clarified that it acts as an important electron transfer conductor that supports energy metabolism, protein quality control, and signal transduction. It is thought that supersulfides sense oxygen and reactive oxygen species and are responsible for their biological activities, and at the same time, they play a key role in the creation of physiological functions of major biomolecules such as nucleic acids and proteins, and support a wide range of biological phenomena. In this symposium, we will introduce cutting-edge technologies on quantitative sulfur omics, sulfur imagings, and chemical modulators necessary for elucidating the functional interactions between supersulfides and various related molecules and biological systems. We will discuss a multidisciplinary approach to building a consortium on global standards for sulfur metabolic flux. Furthermore, we will create innovative biology utilizing these technologies for measuring supersulfides, and renew the biological concept of physiological functions and pathological conditions performed by all living organisms from bacteria to plants and humans.
2S16m
Date:November 10th 9:00-11:00 Place: Room 16（133+134）
Seeing is believing-reconsidering enzymes in 2022- the diversity of structure and function of enzymes and beyond
organizer:
Sachiko TOMA-FUKAI（Nara Institute of Science and Technology)
Teruya Nakamura（Kumamoto University)
Ayako Frukawa（Yokohama City University )
Mizuki Takenaka（Graduate School of Science, Kyoto University)
Shosuke Yoshida（Nara Institute of Science and Technology)
Tadashi Satoh（AgroDesign Studio Inc.)
Hiroaki Matsuura（RIKEN SPring-8 Center)
Teruya Nakamura（Kumamoto University)
Mizuki Takenaka（Graduate School of Science, Kyoto University)
Shosuke Yoshida（Nara Institute of Science and Technology)
Tadashi Satoh（AgroDesign Studio Inc.)
Hiroaki Matsuura（RIKEN SPring-8 Center)
Teruya Nakamura（Kumamoto University)
Enzyme research has developed and evolved with biochemistry over 200 years, pursuing the endless fascination and profundity of the enzyme world. The field of structural biology is now at a critical turning point with the tremendous technological innovation represented by the highly accurate structure prediction with Alpha Fold2. At the biochemistry festival in 2022, we would like to have an opportunity to discuss enzymes from the viewpoint of “functional analysis starting with three-dimensional structures and beyond.” which would be a standard strategy in future structural biology.The speakers of this symposium are not limited to structural biologists and consist of genderless young researchers, ranging from basic researchers in academia who approach the elucidation of the structure and function of enzymes through various experimental methods to the researcher in the industry who is responsible for the social implementation of the design of enzyme inhibitors. In this symposium, we will discuss the future development of enzyme research and its potential from the standpoints of both industry and academia.
2S01e
Date:November 10th 16:40-18:40 Place: Room 1（Reception Hall）
Cholesterol metabolism in physiology and disease control
organizer:
Takehito Uruno（Medical Institute of Bioregulation, Kyushu University)
Yumiko Oishi（Department of Biochemistry & Molecular Biology, Nippon Medical School)
Ryuichiro Sato（Graduate School of Agricultural and Life Sciences, The University of Tokyo)
Esperanza Perucha（Centre for Inflammation Biology and Cancer Immunology;Centre for Rheumatic Diseases, King’s College London)
Hayato Takahashi（Keio University School of Medicine)
Yumiko Oishi（Department of Biochemistry & Molecular Biology, Nippon Medical School)
Hideyuki Oguro（University of Connecticut Health Center)
Kazufumi Kunimura（Medical Institute of Bioregulation, Kyushu University)
Takehito Uruno（Medical Institute of Bioregulation, Kyushu University)
Esperanza Perucha（Centre for Inflammation Biology and Cancer Immunology;Centre for Rheumatic Diseases, King’s College London)
Hayato Takahashi（Keio University School of Medicine)
Yumiko Oishi（Department of Biochemistry & Molecular Biology, Nippon Medical School)
Hideyuki Oguro（University of Connecticut Health Center)
Kazufumi Kunimura（Medical Institute of Bioregulation, Kyushu University)
Takehito Uruno（Medical Institute of Bioregulation, Kyushu University)
Cholesterol is a major component of the cellular membranes, and also converted to steroids and bile acids to regulate diverse physiological functions. In the process of its metabolism, various forms of cholesterol metabolites are generated by the actions of a range of modifying enzymes. Recent studies have revealed that these metabolites are not merely intermediates, but play biological roles in immune regulation and disease development. In this special session, we will showcase these findings, and aim to gain a new insight into the role of cholesterol metabolism in physiology and disease control.
2S02e
Date:November 10th 16:40-18:40 Place: Room 2（141+142）
Biochemical basic research of Developmental Origins of Health and Disease theory
organizer:
Yuichiro Arima（International Research Center for Medical Sciences, Kumamoto University)
Takahiro Nemoto（Department of Physiology, Nippon Medical School
Hiromichi Shoji（Juntendo University Graduate School of Medicine )
Takahiro Nemoto（Nippon Medical School)
Shiori Ishiyama（Yamanashi University)
Kenichi Miharada（International Research Center for Medical Sciences, Kumamoto University)
Wataru Kimura（RIKEN Center for Biosystems Dynamics Research)
Yuichiro Arima（International Research Center for Medical Sciences, Kumamoto University)
Takahiro Nemoto（Nippon Medical School)
Shiori Ishiyama（Yamanashi University)
Kenichi Miharada（International Research Center for Medical Sciences, Kumamoto University)
Wataru Kimura（RIKEN Center for Biosystems Dynamics Research)
Yuichiro Arima（International Research Center for Medical Sciences, Kumamoto University)
Developmental Origins of Health and Disease (DOHaD) is the theory that environmental changes during the fetal period are factors that form the risk of developing non communicable diseases in adult. Low birth weight and small physique are known as a trade-off result by adaptation against the environmental stresses in order to protect vital organs. If poor nutritional environment continues this adaptation favors survival, however, when exposed to excessive nutrition after growth, a mismatch between constitution and environment can be a risk factor for the development of the disease. However, the details of the biochemical mechanisms are still unknown. In this symposium, we introduce the latest findings from researchers who are focusing on the perinatal development, mother-child relationship, and model animals, and approach the physiological and pathophysiological mechanisms of DOHaD.
2S03e
Date:November 10th 16:40-18:40 Place: Room 3（International Conference Rooms）
Regulatory mechanisms of protein fate determination coupled with mRNA translation and its physiological significance
organizer:
Hideki Nishitoh（Department of Medical Sciences, University of Miyazaki)
Tsuyoshi Udagawa（Graduate School of Pharmaceutical Sciences, Tohoku University)
Seiichi Nagano（Osaka University Graduate School of Medicine)
Yuichi Shichino（RIKEN CPR)
Norifumi Shioda（Institute of Molecular Embryology and Genetics. Kumamoto University)
Tatsuhisa Tsuboi（Tsinghua Shenzhen International Graduate School)
Tsuyoshi Udagawa（Graduate School of Pharmaceutical Sciences, Tohoku University)
Hisae Kadowaki（Department of Medical Sciences, University of Miyazaki)
Yuichi Shichino（RIKEN CPR)
Norifumi Shioda（Institute of Molecular Embryology and Genetics. Kumamoto University)
Tatsuhisa Tsuboi（Tsinghua Shenzhen International Graduate School)
Tsuyoshi Udagawa（Graduate School of Pharmaceutical Sciences, Tohoku University)
Hisae Kadowaki（Department of Medical Sciences, University of Miyazaki)
mRNA translation is not merely the process of protein production in the cytosol, but is also important for protein folding, protein transport, quality control of gene expression, and the maintenance of proteostasis. In particular, local translation in organelles such as ER and mitochondria, and in axons and dendrites of neurons, as well as aberrant translation of repeat sequences have a profound effect on protein fate, and the failure to regulate these processes can lead to diverse disease conditions such as neurologic disorders, cancer, and aging. In this symposium, we will introduce the latest researches on these topics, which elucidate molecular mechanisms, biological phenotypes, pathogenesis of human diseases, and the possible therapeutic approaches based on these mechanisms.
2S04e
Date:November 10th 16:40-18:40 Place: Room 4（234）
Deubiquitinating enzymes, which regulate the ubiquitin world, and their importance in disease development and drug discovery
organizer:
Fuminori Tokunaga（Osaka Metropolitan University)
Tsukasa Okiyoneda（Kwansei Gakuin University)
Daisuke Oikawa（Osaka Metropolitan University)
Takaki Asano（Hiroshima University)
Toshiaki Fukushima（Tokyo Institute of Technology)
Hirotaka Takahashi（Ehime University)
Tsukasa Okiyoneda（Kwansei Gakuin University)
Takaki Asano（Hiroshima University)
Toshiaki Fukushima（Tokyo Institute of Technology)
Hirotaka Takahashi（Ehime University)
Tsukasa Okiyoneda（Kwansei Gakuin University)
Protein ubiquitination regulates various cellular functions, such as proteasomal degradation, signal transduction, and so on, and is called a ubiquitin code because of its functional diversity and structural complexity. Deubiquitinating enzymes (DUBs) are responsible for the elimination and editing of the ubiquitin code, and there are approximately 100 DUBs in human genome. Since genetic mutations of DUBs are associated with various diseases, they are also important as drug discovery targets. More recently, a new method (DUBTAC) has been proposed in which a chimeric compound that links DUB and a target protein leads to suppression of degradation of the target substrate. In this symposium, we will focus on DUBs related to human diseases, and introduce their cellular and physiological functions, pathological mechanism, and the development for drug discovery. Moreover, we will discuss the future prospects of DUB research.
2S05e
Date:November 10th 16:40-18:40 Place: Room 5（231）
TBA
organizer:
Eimi Nishimura（ The University of Tokyo）
Makoto Nakanishi（ The University of Tokyo）
2S06e
Date:November 10th 16:40-18:40 Place: Room 6（232+233）
PRESTO “Function and control of fine particles in a living body" achievement report
organizer:
Akihiko Nakano（RIKEN/Center for Advanced Photonics)
Koshi Imami（Kyoto University/Graduate School of Pharmaceutical Sciences)
sponsor: JST PRESTO “Function and control of fine particles in a living body"
Akihiko Nakano（RIKEN)
Koshi Imami（Kyoto University)
Shunsuke Kimura（Keio University)
Yusuke Sato（Tohoku University)
Yoshitaka Sato（Nagoya University)
Kenji Sueyoshi（Osaka Prefecture University)
Yosuke Tashiro（Shizuoka University)
Koshi Imami（Kyoto University)
Shunsuke Kimura（Keio University)
Yusuke Sato（Tohoku University)
Yoshitaka Sato（Nagoya University)
Kenji Sueyoshi（Osaka Prefecture University)
Yosuke Tashiro（Shizuoka University)
In recent years, effects of various fine particles from environment (exogenous fine particles) like PM2.5 and carbon nanotubes to a living body and functions of fine particles in a living body (endogenous fine particles) like exosomes have been focused. JST PRESTO project “Function and control of fine particles in a living body”, starting on October 2017, has promoted elucidation of dynamics and functions of fine particles and R&D aimed at their control. This time, as a second achievement report of this project, five PRESTO researchers will introduce their newly developed practical methods based on new techniques to analyze in vivo dynamics of fine particles and the findings on biological functions and significance of fine particles.We would like to use this opportunity to acquire various comments and advices on our projects from a broad point of view and develop our research further to contribute to various solutions of environmental and health problems.
2S07e
Date:November 10th 16:40-18:40 Place: Room 7（224）
Modification of cell functions by engineering membrane lipid metabolism
organizer:
Hisashi Hemmi（Graduate School of Bioagricultural Sciences, Nagoya University)
Tatsuo Kurihara（Institute for Chemical Research, Kyoto University)
Hisashi Hemmi（Graduate School of Bioagricultural Sciences, Nagoya University)
Arnold J. M. Driessen（Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen)
Kohjiro Nagao（Graduate School of Engineering, Kyoto University)
Takuya Ogawa（Institute for Chemical Research, Kyoto University)
Arnold J. M. Driessen（Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen)
Kohjiro Nagao（Graduate School of Engineering, Kyoto University)
Takuya Ogawa（Institute for Chemical Research, Kyoto University)
Accumulation of knowledges on lipid metabolism has enabled modification of the lipid composition of the cellular membrane of an organism, as well as the physical properties of the membrane. Such changes on the cellular membrane caused, for example, by the production of specific membrane lipids derived from different organisms or by the disruption of endogenous membrane lipid composition may affect the cell’s physiology. With the aim of the construction of cells with superior properties, which is one of the most important goals in synthetic biology and metabolic engineering, researchers have tackled mainly the alteration of enzymes and metabolic pathways, while the artificial modification of membranes will also contribute to the achievement of the goal. This symposium highlights some recent topics that have enabled the alteration or regulation of lipid composition in cellular membranes of bacteria and drosophila, and resultantly have revealed their physiological effects on the cells.
2S08e
Date:November 10th 16:40-18:40 Place: Room 8（221）
Development of new immunotherapies based on the elucidation of immune regulatory mechanisms
organizer:
Hiroyoshi Nishikawa（Department of Immunology, Nagoya University Graduate School of Medicine)
Osamu Takeuchi（Department of Medical Chemistry, Kyoto University Graduate School of Medicine)
Taku Okazaki（Laboratory of Molecular Immunology, Institute for Quantitative Biosciences,The University of Tokyo)
Akihiko Yoshimura（Keio University)
Osamu Takeuchi（Department of Medical Chemistry, Kyoto University Graduate School of Medicine)
Hiroyoshi Nishikawa（Department of Immunology, Nagoya University Graduate School of Medicine)
Michael Bassik（Stanford University)
James L Reading（UCL Cancer Institute )
Akihiko Yoshimura（Keio University)
Osamu Takeuchi（Department of Medical Chemistry, Kyoto University Graduate School of Medicine)
Hiroyoshi Nishikawa（Department of Immunology, Nagoya University Graduate School of Medicine)
Michael Bassik（Stanford University)
James L Reading（UCL Cancer Institute )
With the clinical application of cancer immunotherapy, research on immunomodulatory mechanisms has greatly expanded, and new therapeutic methods are being applied clinically. The development of therapeutic methods based on the results of these basic researches will be unraveled again from the perspective of basic research.
2S09e
Date:November 10th 16:40-18:40 Place: Room 9（222）
Multifunctionality of Non-Canonical Structures of Nucleic Acids
organizer:
Miki Imanishi（Institute for Chemical Research, Kyoto University)
Hisae Tateishi-Karimata（Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University)
sponsor:
MEXT Grant-in-Aid for Scientific Research on Transformative Research Areas (B) “Elucidation of the mechanism for dimensional response genome across species regulated by nucleic acid structures"
Hisae Tateishi-Karimata（Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University)
Satoru Nagatoishi（The Institute of Medical Science, The University of Tokyo)
Tamaki Endoh（Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University)
Takanori Oyoshi（Graduate School of Science and Technology, Shizuoka University)
Miki Imanishi（Institute for Chemical Research, Kyoto University)
Yasushi Yabuki（Institute of Molecular Embryology and Genetics, Kumamoto University)
Satoru Nagatoishi（The Institute of Medical Science, The University of Tokyo)
Tamaki Endoh（Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University)
Takanori Oyoshi（Graduate School of Science and Technology, Shizuoka University)
Miki Imanishi（Institute for Chemical Research, Kyoto University)
Yasushi Yabuki（Institute of Molecular Embryology and Genetics, Kumamoto University)
Recently, it has become clear that various structures other than the double-helix structure formed by DNA and RNA (non-canonical structures) in cells play important roles in gene expression. However, many unanswered questions still remain regarding the diverse physiological functions of non-canonical structures of nucleic acids, which are dynamically affected by the surrounding environment. In this symposium, young researchers will present a wide range of topics on the physiological significance of non-canonical structures of nucleic acids including the quadruplex structure, from biochemical findings to their relevance to pathological conditions. Through this symposium, we aim to induce interdisciplinary research with the keyword of “multidimensional functions of nucleic acid structures”.
2S10e
Date:November 10th 16:40-18:40 Place: Room 10（223）
Implementation of basic science: challenges to become entrepreneurs of startups
organizer:
Atsushi Enomoto（Department of Pathology, Nagoya University Graduate School of Medicine)
Takeshi Urano（Department of Biochemistry, Shimane University School of Medicine)
Hiroyuki Kabayama（STAND Therapeutics. Co., LTD.)
Norihiro Yumoto（Jiksak Bioengineering, Inc.)
Naohiro Makita（Myoridge Co. Ltd.)
Takeshi Urano（mAbProtein Co.,Ltd)
Norihiro Yumoto（Jiksak Bioengineering, Inc.)
Naohiro Makita（Myoridge Co. Ltd.)
Takeshi Urano（mAbProtein Co.,Ltd)
Many researchers in the field of basic science have been struggling against the issue to win research grants that they need to make out their research proposals, as if they seem to contribute to the resolution of health and social problems. Meanwhile, implementation of research findings is an essential process that leads to the improvement of our society and advances in medicine. This has been achieved by many startups founded by researchers in western countries, which has been in turn beneficial for the promotion of high-level science. Thus, aiming at the implementation of our research findings is quite different from writing unintended research proposals and does not exclude the importance of basic science development. In this symposium, we will talk with four founders of biotech startups who were previously undergraduate students, researchers, and post-docs. They will share with us their fun and stories about the difficulties that they experienced, as well as provide advice for young researchers who hope to start their own businesses based on their research findings.
2S11e
Date:November 10th 16:40-18:40 Place: Room 11（211）
The Pleiotropic Nuclear-envelope Biology
organizer:
Richard Wong（Nano Life Science institute (WPI-NanoLSI), Kanazawa University)
Takeshi Shimi（Institute of Innovative Research, Tokyo Institute of Technology)
Ohad Medalia（Department of Biochemistry, University of Zurich)
Robert Goldman（Feinberg School of Medicine, Northwestern University)
Noriko Yasuhara（Department of Life Science, College of Humanities and Sciences, Nihon University)
Takeshi Shimi（Institute of Innovative Research, Tokyo Institute of Technology)
Richard Wong（Nano Life Science institute (WPI-NanoLSI), Kanazawa University)
Masaharu Hazawa（Institute for Frontier Science Initiative, Kanazawa University)
Naoko Imamoto（RIKEN Cluster for Pioneering Research)
Tokuko Haraguchi（Graduate School of Frontier Biosciences, Osaka University)
Robert Goldman（Feinberg School of Medicine, Northwestern University)
Noriko Yasuhara（Department of Life Science, College of Humanities and Sciences, Nihon University)
Takeshi Shimi（Institute of Innovative Research, Tokyo Institute of Technology)
Richard Wong（Nano Life Science institute (WPI-NanoLSI), Kanazawa University)
Masaharu Hazawa（Institute for Frontier Science Initiative, Kanazawa University)
Naoko Imamoto（RIKEN Cluster for Pioneering Research)
Tokuko Haraguchi（Graduate School of Frontier Biosciences, Osaka University)
This proposed symposium will provide an interdisciplinary forum for researches from different disciplines–from biochemistry, cell biology, cryo-ET and nano-imaging to talk over both basic and applied aspects of the nuclear envelope (NE).The NE is a characteristic structure of eukaryotic cells that dynamically changes throughout the cell cycle. In mammalian cell nuclei, the nuclear lamina (NL) lines the inner nuclear membrane of the NE whereas nuclear pore complexes (NPCs) penetrate through the NE. The NL and NPCs are completely dismantled during NE breakdown and reformed before mitotic exit.The nuclear lamins, the major structural determinants of the NL, are involved in the maintenance of nuclear structure and the protection against NE rupture induced by mechanical stress. Numerous mutations in lamin genes cause a wide range of human genomic disorders called as laminopathies.The structure, dynamics, and function of NPCs is extremely diverse in different cell types and states, and they do not only facilitate nucleocytoplasmic trafficking of macromolecules but also support a wide variety of biological phenomena. In particular, dynamics and function of NPCs contribute to various viral infections; carcinogenesis; autophagy; phase separation driven by NPC proteins (FG-NUPs) are hot topics in the fields.Particular focus of the proposed symposium will be to foster the application of cryo-ET, nano imaging devices (HS-AFM, STED) application to investigate the interaction between experimental and theoretical approaches aimed for relating the dynamic structure of NL and NPC proteins to their functions, and understanding mechanisms of the NL and NPC rupture.
2S12e
Date:November 10th 16:40-18:40 Place: Room 12（212）
Soft X-ray microscopy (SXTM) as a mesoscale imaging technique
organizer:
Leonard Chavas（Nagoya University Synchrotron-radiation Research center)
Yasufumi Umena（Nagoya University Synchrotron-radiation Research center)
sponsor: Carl Zeiss Co. Ltd.
Eva Pereiro（ALBA synchrotron)
Frederic Jamme（Synchrotron SOLEIL)
Beatriz Guimarães（Instituto Carlos Chagas)
Takahiro Teramoto（Institute of Radiation Science and Technology, Osaka University)
Frederic Jamme（Synchrotron SOLEIL)
Beatriz Guimarães（Instituto Carlos Chagas)
Takahiro Teramoto（Institute of Radiation Science and Technology, Osaka University)
The functional study of proteins benefits from the integration of various forms of cross-disciplinary and multitaxon research. The state-of-the-art of structural biology combines X-ray diffraction and cryo-electron microscopy techniques, providing atomic details of these molecules. Meanwhile, mesoscale imaging of cellular ultrastructures at intermediate resolutions (25-40 nm) through cryo-soft X-ray tomography (SXTM) can be correlated with the structural information of proteins and other imaging methods. The great advantages provided by cryo-SXTM to the field of functional and structural biology and more generally to biochemistry will be discussed, with the hope to dress a strong interest from the international and Japanese community toward this fantastic yet under-represented technique.
2S13e
Date:November 10th 16:40-18:40 Place: Room 13（431）
Chronobiology - Diversity of entrainment factors
organizer:
Norio Ishida（Institute for Chronobiology. Foundation for Advancement of International Science)
Toshiyuki Okano（Waseda University)
Toshiyuki Okano（Waseda University)
Haruhisa Kawasaki（Foundation for Advancement of International Science)
Eiji Inoue（KYUSHIN PHARMACEUTICAL CO., LTD)
Hidenobu Ohta（Akita University)
Yasuko Abe（The University of Tokyo / Tokyo Metropolitan Institute of Medical Science)
Haruhisa Kawasaki（Foundation for Advancement of International Science)
Eiji Inoue（KYUSHIN PHARMACEUTICAL CO., LTD)
Hidenobu Ohta（Akita University)
Yasuko Abe（The University of Tokyo / Tokyo Metropolitan Institute of Medical Science)
Goal of chronobiology is to understand interplay between oscillation in our body and oscillation in environment. Chronobiology dissolves health and disease mechanism through discovery of clock genes and their proteins. 24hr. period is reflected by the earth rotation as well as the revolution. Furthermore, our satellite moon affects many biological and biochemical oscillation in our body, but its precise molecular mechanism is under investigation. The expression of clock genes is affected by many environmental cues, light, temperature, magnetic field, electric field and foods. Interplay between environmental changes and clock gene expression is a drive force for adaptation for life on earth. In this meeting, we gathered many biochemists from this field for our hot discussion with floors.
2S14e
Date:November 10th 16:40-18:40 Place: Room 14（432）
Chromatin Dynamics and Epigenetic Regulation
organizer:
Jun-ichi Nakayama（National Institute for Basic Biology)
Hitoshi Kurumizaka（Institute for Quantitative Biosciences, The University of Tokyo)
Hitoshi Kurumizaka（The University of Tokyo)
Kei-ichiro Ishiguro（Kumamoto University)
Makoto Tachibana（Osaka University)
Yasuyuki Ohkawa（Kyushu Univetsity)
Jinrong Min（University of Toronto)
Kei-ichiro Ishiguro（Kumamoto University)
Makoto Tachibana（Osaka University)
Yasuyuki Ohkawa（Kyushu Univetsity)
Jinrong Min（University of Toronto)
Chromatin, a complex of DNA and nuclear proteins found in eukaryotic cells, plays a pivotal role in controlling gene expression, and dynamic change of this chromatin structure provide a molecular basis for epigenetic phenomena. Recent studies have identified a variety of histone modifications and those interacting proteins, and epigenome information has become available from massive ChIP analyses. In addition, high-resolution imaging techniques and 3D mapping technology have uncovered nuclear structures and subdomains. However, the detailed mechanisms underlying chromatin dynamics and how it regulates higher life phenomena remain elusive. In this symposium, we will integrate recent advances and try to provide a comprehensive view for chromatin dynamics underlying epigenetic gene regulation.
2S15e
Date:November 10th 16:40-18:40 Place: Room 15（131+132）
Intracellular signaling diversity revealed by innovative sulfur research
organizer:
Ryo Ushioda（Faculty of Life Sciences, Kyoto Sangyo University)
Yoshiro Saito（Graduate School of Pharmaceutical Sciences, Tohoku University)
Yoshiro Saito（Graduate School of Pharmaceutical Sciences, Tohoku University)
Hiroaki Miki（Research Institute for Microbial Diseases, Osaka University)
FANYAN WEI（Department of Modomics Biology and Medicine, IDAC, Tohoku University)
Tetsuro Matsunaga（Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine)
Yasuniro Ishimaru（School of Engineering, Tohoku University)
Takayuki Shimizu（Graduate School of Arts and Sciences, The University of Tokyo)
Hiroaki Miki（Research Institute for Microbial Diseases, Osaka University)
FANYAN WEI（Department of Modomics Biology and Medicine, IDAC, Tohoku University)
Tetsuro Matsunaga（Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine)
Yasuniro Ishimaru（School of Engineering, Tohoku University)
Takayuki Shimizu（Graduate School of Arts and Sciences, The University of Tokyo)
The sulfur atom is an element belonging to Group 16 of the periodic table along with oxygen and selenium. Compared to oxygen, which many organisms use as an electron acceptor, sulfur has lower first ionization energy and a higher electron affinity. This means that the sulfur atom is more excellent in the transfer of electrons, and plays an important role as an electronic mediator for various biological reactions. Recent studies have revealed that the catenation of sulfur called poly-sulfur supports the basis of biological phenomenon, and it is expected that these advanced sulfur researches will change the principle of life. State-of-the-art technology has enabled the detection of a variety of sulfur modifications and reaction intermediates, revealing previously unpredictable intracellular signal transduction. Here, in addition to sulfur research, we will also focus on highly reactive selenium and introduce the mechanism of intracellular signal transduction that renews conventional wisdom.
2S16e
Date:November 10th 16:40-18:40 Place: Room 16（133+134）
Transcriptional activation and repression – Understanding of gene expression regulation from the front and back
organizer:
Juro SAKAI（Tohoku University Graduate School of Medicine / Division of Metabolic Medicine, RCAST, The University of Tokyo)
Yoichi SHINKAI（RIKEN)
Kei FUKUDA（Cellular Memory Laboratory, CPR, RIKEN)
Taiko TOU（Graduate School of Science, The Univ. of Tokyo)
Ryo Maeda（Graduate School of Frontier Biosciences (FBS), Osaka University)
Naoki KUBO（Medical Institute of Bioregulation, Kyushu University)
Azusa INOUE（RIKEN IMS)
Yoshihiro MATSUMURA（Division of Metabolic Medicine, RCAST, The University of Tokyo / Tohoku University Graduate School of Medicine)
Taiko TOU（Graduate School of Science, The Univ. of Tokyo)
Ryo Maeda（Graduate School of Frontier Biosciences (FBS), Osaka University)
Naoki KUBO（Medical Institute of Bioregulation, Kyushu University)
Azusa INOUE（RIKEN IMS)
Yoshihiro MATSUMURA（Division of Metabolic Medicine, RCAST, The University of Tokyo / Tohoku University Graduate School of Medicine)
Cells receive various external stimuli, decide the necessity of gene function, and exert their unique functions through transcription. Epigenome such as DNA methylation and histone modifications either activates or represses transcription to regulate gene expression in cooperation with higher-order chromatin structures. Transcriptional activation and repression are two sides of the same coin. For example, the functional imbalance between histone methyltransferases and demethylases, or transcriptional coactivators and corepressors, allows for flexible transcriptional activation and inactivation associated with differentiation. Knowing such relationships lead to a deep understanding of gene expression regulation, which is the basis of life phenomena. In this symposium, we would like to discuss the latest topics on gene expression regulation through dynamic changes in the epigenome and higher-order chromatin structures.
3S01m
Date:November 11th 9:00-11:00 Place: Room 1（Reception Hall）
A new era of “soft" biopolymers
organizer:
Yukihide Tomari（The University of Tokyo)
Shintaro Iwasaki（RIKEN)
Shinichi Nakagawa（Hokkaido University)
Alex Holehouse（Washington University School of Medicine)
Liam Holt（New York University Langone Health)
Stephanie Moon（University of Michigan Medical School)
Yoshiho Ikeuchi（The University of Tokyo)
Alex Holehouse（Washington University School of Medicine)
Liam Holt（New York University Langone Health)
Stephanie Moon（University of Michigan Medical School)
Yoshiho Ikeuchi（The University of Tokyo)
Biomolecules without rigid structures, including long non-coding RNAs and intrinsically disordered proteins, have recently been shown to control many important biological processes, including intracellular molecular crowding, formation of non-membranous granules, and regulation of macromolecular complexes such as transcriptional and translational machineries. It is thought that their molecular functions do not depend on conventional lock-and-key-type interactions but rather on loose and plastic interactions, which are difficult to predict from their primary sequences. In this symposium, we focus on a variety of novel approaches for characterizing these “soft” biopolymers, and discuss the previously unrecognized strategy for organisms to gain new functions without relying on the conservation of primary sequences during evolution.
3S02m
Date:November 11th 9:00-11:00 Place: Room 2（141+142）
"Control of Immune system through Metabolic Manipulation" : New Insights into the Immune-Metabolic Network that Controls Disease
organizer:
Yusuke Endo（KAZUSA DNA Research Institute)
Masakatsu Yamashita（Graduate School of Medicine, Ehime University)
Naotada Ishihara（Graduate School of Science, Osaka University)
Takayoshi Suganami（Research Institute of Environmental Medicine, Nagoya University)
Katsuyuki Yugi（IMS RIKEN Center for Integrative Medical Sciences)
Masakatsu Yamashita（Graduate School of Medicine, Ehime University)
Yusuke Endo（KAZUSA DNA Research Institute)
Takayoshi Suganami（Research Institute of Environmental Medicine, Nagoya University)
Katsuyuki Yugi（IMS RIKEN Center for Integrative Medical Sciences)
Masakatsu Yamashita（Graduate School of Medicine, Ehime University)
Yusuke Endo（KAZUSA DNA Research Institute)
The translation of “Immunometabolism” is the critical connection between systemic and cellular metabolism. There are two aspects of consideration of immunometabolism. One is the effect of inflammation and immune responses on the control of systemic metabolism. The other focuses on metabolism within immune cells. Clearly, metabolic changes in immune cells have important determinants on the specific effector function of these cell types. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. Furthermore, a recent development of analytical technology has revealed the detailed molecular mechanisms by which cellular metabolic pathways such as glycolysis, mitochondrial metabolism, and lipid metabolism controls immune cell function. In this symposium, 5 speakers will provide the latest topics on the forefront of immunometabolism and deeply discuss how selective metabolic programs operate in distinct immune cell subsets and metabolic functions will deliver tools for cell- and function-specific targeting of therapeutic immunomanipulation in various diseases.
3S03m
Date:November 11th 9:00-11:00 Place: Room 3（International Conference Rooms）
New Frontier in Ubiquitin-Proteasome Research
organizer:
Yasushi Saeki（Tokyo Metropolitan Institute of Medical Science)
Shigeo Murata（The University of Tokyo)
sponsor: Grant-in-Aid for Scientific Research on Innovative Areas ”New frontier for ubiquitin biology driven by chemo-technologies”
Yasushi Saeki（Tokyo Metropolitan Institute of Medical Science)
Shigeo Murata（The University of Tokyo)
Toshifumi Inada（The University of Tokyo)
Hiroyuki Kawahara（Tokyo Metropolitan University)
Fumiaki Ohtake（Hoshi University)
Gosuke Hayashi（Nagoya University)
Yosuke Demizu（National Institute of Health Sciences)
Shigeo Murata（The University of Tokyo)
Toshifumi Inada（The University of Tokyo)
Hiroyuki Kawahara（Tokyo Metropolitan University)
Fumiaki Ohtake（Hoshi University)
Gosuke Hayashi（Nagoya University)
Yosuke Demizu（National Institute of Health Sciences)
The ubiquitin-proteasome system is a crucial proteolytic pathway that regulates almost all cellular functions. Driven by the explosive progress in ubiquitin drug discovery represented by PROTAC, today’s ubiquitin-proteasome research is expanding through interdisciplinary collaborations using chemical approaches. In this symposium, leading researchers working on novel ubiquitin biology research such as translation control and phase separation, development of targeted protein degraders and ubiquitin chemical probes using cutting-edge strategies, and next-generation ubiquitin-proteasome research using these technologies will gather to present their latest research results.
3S04m
Date:November 11th 9:00-11:00 Place: Room 4（234）
Human glycome develops new frontiers in disease biology
organizer:
Chihiro Sato（Institute for Glyco-core Research, Nagoya University)
Eiji Miyoshi（Osaka University Graduate School of Medicine)
Jin-ichi Inokuchi（Tohoku Medical and Pharmaceutical University)
Kenta Moriwaki（Toho University School of Medicine)
Shinobu Kitazume（School of Health Sciences, Fukushima Medical University)
Chihiro Sato（Institute for Glyco-core Research, Nagoya University)
Jun-ichi Furukawa（Department of Advanced Clinical Glycobiology, Hokkaido University)
Atsushi Kuno（Cellular and Molecular Biotechnology Research Institute, AIST)
Kenta Moriwaki（Toho University School of Medicine)
Shinobu Kitazume（School of Health Sciences, Fukushima Medical University)
Chihiro Sato（Institute for Glyco-core Research, Nagoya University)
Jun-ichi Furukawa（Department of Advanced Clinical Glycobiology, Hokkaido University)
Atsushi Kuno（Cellular and Molecular Biotechnology Research Institute, AIST)
Thanks to prominent advances in analytical technologies of genome, transcriptome, and proteome, together with those of information sciences, life sciences have greatly changed in their methodology. In biomedical research area, relationships of disease with genome, transcriptome, and proteome have easily allowed us to identify genetic and environmental factors for the disease, demonstrating the usefulness of omic analysis in this area. Compared with DNA, RNA, and protein structures, the understanding of glycome (glycans) lagged behind, because extremely complex and heterogenous glycan structures prevent us from easy determination of their structures, and is now an urgent subject to be solved in life sciences. In this symposium, we are sharing impacts of human glyome in biomedical research on disease and aging, focusing on the cutting-edge and innovative researches.
3S05m
Date:November 11th 9:00-11:00 Place: Room 5（231）
The latest research and drug development targeting protein phosphatases through the cross-disciplinary approaches
organizer:
Yoshiro Chuman（Department of Chemistry, Faculty of Science, Niigata University)
Hiroshi Ohnishi（Gunma University Graduate School of Health Sciences, Department of Laboratory Sciences)
Takashi Ohama （Joint Faculty of Veterinary Medicine, Yamaguchi University)
Kazuyasu Sakaguchi（Department of Chemistry, Faculty of Science, Hokkaido University)
Yuki Goto （Department of Chemistry, Graduate School of Science, The University of Tokyo)
Takenori Kotani （Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine)
Yutaka Hirose（Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama)
Jun Takouda （Department of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University)
Yoshiro Chuman（Department of Chemistry, Faculty of Science, Niigata University)
Kazuyasu Sakaguchi（Department of Chemistry, Faculty of Science, Hokkaido University)
Yuki Goto （Department of Chemistry, Graduate School of Science, The University of Tokyo)
Takenori Kotani （Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine)
Yutaka Hirose（Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama)
Jun Takouda （Department of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University)
Yoshiro Chuman（Department of Chemistry, Faculty of Science, Niigata University)
Protein phosphorylation controls multiple biological processes, and the abnormal regulation of this system lead to various diseases. Phosphorylation is dynamically regulated by both kinases and phosphatases, however, the functions of phosphatases are less understood. Protein phosphatases have been attractive targets not only for the understanding of various functions in signal transduction but also for the development of drugs such as anti-cancer agents. In this symposium, we will introduce the latest progress in this research field and discuss future prospects of drug development based on the results through the cross-disciplinary approaches. The aim of this symposium is to cultivate novel research areas in biochemistry through the discussions on the novel biological functions of protein phosphatases and the drug-development targeting these molecules.
3S06m
Date:November 11th 9:00-11:00 Place: Room 6（232+233）
Development of high-sensitive and high-throughput omics technologies which leads to next-generation research
organizer:
Tomoyoshi Soga（Institute for Advanced Biosciences, Keio University)
Yasushi Ishihama（Laboratoty of Molecular & Cellular BioAnalysis, Kyoto University)
Takayuki Kawai（Department of Chemistry, Graduate of Sciences, Kyusyu University )
Tomoyoshi Soga（Institute for Advanced Biosciences, Keio University)
Takeshi Masuda（Faculty of Life Sciences, Kumamoto University)
Yasushi Ishihama（Laboratoty of Molecular & Cellular BioAnalysis, Kyoto University)
Yutaka Suzuki（Graduate School of Frontier Sciences, The University of Tokyo)
Omics technologies can reveal the connection of biochemical networks and provide a systems-level understanding, and thus they have been widely used in almost all science including biochemistry. However, existing omics methods still lack sensitivity and throughput to achieve single-cell analysis and rapid analysis. Therefore, the development of ultra-high sensitivity and throughput omics technologies remains one of the most demanding challenges. Recent innovations in separation techniques, sequencer and mass spectrometry have enabled to develop the method not only for single-cell transcriptomics, proteomics and metabolomics, but also for one-minute proteomics and metabolomics. In this symposium, we will invite researchers who are developing cutting-edge omics technologies and discuss their pioneering works including application.
3S07m
Date:November 11th 9:00-11:00 Place: Room 7（224）
Cardiovascular metabolism 2.0
organizer:
Tomohisa Sakaue（Ehime university)
Mizuko Osaka（Tokyo Medical and Dental University)
Masako Nishikawa（The university of Tokyo)
Mizuko Osaka（Tokyo Medical and Dental University)
Naoki Honkura（Hamamatsu University School of Medicine School of Medicine)
Dai Kusumoto（Keio University School of Medicine)
Tomohisa Sakaue（Ehime university)
Mizuko Osaka（Tokyo Medical and Dental University)
Naoki Honkura（Hamamatsu University School of Medicine School of Medicine)
Dai Kusumoto（Keio University School of Medicine)
Tomohisa Sakaue（Ehime university)
The understanding of pathological and molecular mechanisms has been developed by analyzing the functions of isolated molecules from living organisms in conventional cardiovascular metabolism. Recent development of comprehensive gene expression analysis and live imaging technologies, as well as breakthroughs in information analysis technologies have made it possible to understand the molecular and cellular networks with spatial temporal information. This symposium presents the latest research data based on the innovative technologies and discusses the future outlooks of cardiovascular metabolism 2.0 by fusing biochemistry and data-driven cardiovascular metabolism.
3S08m
Date:November 11th 9:00-11:00 Place: Room 8（221）
Contaminated molecular behavior, response, and visualization on/in “stage" of biological membranes
organizer:
Ikuhiko Nakase（Graduate School of Science, Osaka Metropolitan University)
Tomonori Tamura（Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University)
Kenji Inaba（Institute of Multidisciplinary Research for Advanced Materials, Tohoku University)
Tomoka Takatani-Nakase（Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University)
Yuriko Higuchi （Graduate School of Pharmaceutical Sciences, Kyoto University)
Tasuku Hirayama（Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University)
Tomonori Tamura（Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University)
Tomoka Takatani-Nakase（Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University)
Yuriko Higuchi （Graduate School of Pharmaceutical Sciences, Kyoto University)
Tasuku Hirayama（Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University)
Tomonori Tamura（Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University)
Biological membranes have essential and multilateral functionalities for acceptance/rejection of molecular stimulation and environmental changes, leading to signal transduction and total cellular responses. Elucidation for contaminated molecular behavior and response on/in “stage” of cell membrane certainly leads to understanding biological functions with order and flexibility. In this symposium, related membrane proteins such as transporters, protein quality control, and their cellular responses/detection system will be presented by up-and-coming top-class researchers, and innovative research fusion will be also discussed including e.g., novel-labelling methods for contaminated membrane molecules, quality control in endoplasmic reticulum, metal ion for cancer progression, and controlled cellular behavior by cell membrane modification.
3S09m
Date:November 11th 9:00-11:00 Place: Room 9（222）
Biochemical approaches for the regulation of DNA replication, repair and chromosomal structure
organizer:
Yoshitaka Kawasoe（Kyushu University)
Torahiko Higashi（Kyushu University)
Hisao Masai（Tokyo Metropolitan Institute of Medical Science)
Sonoko Ishino（Kyushu University)
Shoko Sato（The University of Tokyo)
Ryusei Yoshida（Kyushu University)
Kentaro Ito（Tokyo Institute of Technology)
Torahiko Higashi（Kyushu University)
Yoshitaka Kawasoe（Kyushu University)
Sonoko Ishino（Kyushu University)
Shoko Sato（The University of Tokyo)
Ryusei Yoshida（Kyushu University)
Kentaro Ito（Tokyo Institute of Technology)
Torahiko Higashi（Kyushu University)
Yoshitaka Kawasoe（Kyushu University)
Chromosomal DNA, which carries genetic information, requires accurate replication, stable maintenance, and inheritance to the next generation. Since a high-order chromosomal complex is formed by DNA and a large number of proteins, the mechanism of essential reactions on the chromosome is complicated. Although previous researches have characterized reactions acted on chromosomes, we have not understood all the detailed mechanisms. To further understand chromosome maintenance at the molecular level, we need to apply biochemical researches such as structural analysis and in vitro reconstruction studies. Here, we will show latest biochemical researches on DNA replication, repair, and chromosome structure in the three domains of bacteria, archaea, and eukaryotes, and we would like to discuss about the mechanism of chromosome maintenance as well as their evolutionary conservation and variety.
3S10m
Date:November 11th 9:00-11:00 Place: Room 10（223）
Down syndrome complex pathology produces neo-biochemistry from the basic to the clinic
organizer:
Takashi Minami（Div. Mol.Vasc.Biol. IRDA, Kumamoto University)
Nariko Arimura（Dept. Biochem.Cell. Biol., National Center of Neurology and Psychiatry)
Kotaro Yokode（Graduate School of Medicine, Chiba University)
Takuro Nakagawa（Dept. Biol.Sci. Graduate School of Science, Osaka University)
Futoshi Suizu（Dept. Pathology and Host-Defense, Faculty of Medicine, Kagawa University)
Nariko Arimura（Dept. Biochem.Cell. Biol., National Center of Neurology and Psychiatry)
Takashi Minami（Div. Mol.Vasc.Biol. IRDA, Kumamoto University)
Takuro Nakagawa（Dept. Biol.Sci. Graduate School of Science, Osaka University)
Futoshi Suizu（Dept. Pathology and Host-Defense, Faculty of Medicine, Kagawa University)
Nariko Arimura（Dept. Biochem.Cell. Biol., National Center of Neurology and Psychiatry)
Takashi Minami（Div. Mol.Vasc.Biol. IRDA, Kumamoto University)
Down syndrome (DS) is the most familiar chromosome trisomy disease with multi-symptom in the whole body in various life stages. However, we could not find any therapeutic ways; thus, DS has also been considered the most familiar disease as a typical unmet medical need. Previous epidemiological mega-studies indicate that DS individuals have an increased risk of neuronal diseases, including early onset of Alzheimer’s pathology, cardiac malformations, acute leukemia, lymphedema, and osteoporosis at younger ages. On the other hand, unexpectedly, they have considerably reduced incidences of most solid tumors, advanced atherosclerosis, and hypertension in older life stages. Such a nonlinear phenotype suggests that the trisomy gene’s network or spatial structure on the 21st chromosome is at least responsible for protecting against severe vascular diseases. Moreover, it has recently been reported cells from DS impaired primary cilia function. Thus, we reconsider the DS mediated complex phenomena should be re-evaluated with various approaches involving chromosome/ chromatin dynamics, cell movement, nerve-vessel oriented microenvironment, and the total pathological biology in whole aging life stages.In this symposium, we would like to discuss the multi-faced new biochemical study based on the pathophysiology of DS and the related lifestyle diseases through advanced research topics.
3S11m
Date:November 11th 9:00-11:00 Place: Room 11（211）
New trends for development of antibodies
organizer:
Yuji Ito（Kagoshima University)
Akikazu Murakami（Tokushima University)
sponsor: AMED Science and Technology Platform Program for Advanced Biological Medicine
Yuji Ito（Kagoshima University)
Akikazu Murakami（Tokushima University)
Naoto Nemoto（Saitama University)
Mitsuo Umetsu（Tohoku University)
Yoshihisa Hagihara（National Institute of Advanced Industrial Science and Technology)
Akikazu Murakami（Tokushima University)
Naoto Nemoto（Saitama University)
Mitsuo Umetsu（Tohoku University)
Yoshihisa Hagihara（National Institute of Advanced Industrial Science and Technology)
Antibody is a protein which has been widely used in industries from detection reagent to antibody drug. However, its high specificity and functionality have the potential to lead to the expansion of its uses by the new production and improvement methods of antibodies which are targeted toward a wide variety of novel molecules, as well as conventional uses. In this symposium, we will focus on the next-generation method of antibody production and improvement that has evolved from conventional methods to consider their current situations and prospects. A total of five speakers will present their talks about VHH antibody library by artificial design which enables to acquire antibodies to various molecules, cDNA display library with an extremely large diversity, highly functional antibodies by smart design, multifunctional antibodies by chemical modification, and high affinity antibodies by analyzing immune responses.
3S12m
Date:November 11th 9:00-11:00 Place: Room 12（212）
A new paradigm for sucrose and fructose metabolism
organizer:
Hiroaki Oda（Graduate School of Bioagricultural Sciences, Nagoya University)
Katsumi Iizuka（Fujita Health University)
Speakers:
Oda Hiroaki（Graduate School of Bioagricultural Sciences, Nagoya University)
Naoya Yahagi（University of Tsukuba)
Takuji Ishimoto（Aichi Medical University)
Katsumi Iizuka（Fujita Health University)
There has been a renewed focus on the fact that one of the causes of the increase in obesity and metabolic syndrome is the excessive intake of added sugars such as sucrose, fructose, and high-fructose corn syrup. It is well known that excessive intake of fructose leads to fatty liver and hypertriglyceridemia, and many biochemistry textbooks say that the cause is the rapid flow of fructose into the liver, which is quickly metabolized, depleting ATP and producing large amounts of substrates for lipid synthesis. Many of these are based on results from a half century ago. However, recent research has revealed that ingested fructose is metabolized mainly in the small intestine and not in the liver in large quantities as previously thought. In addition, fructose that is not metabolized in the small intestine enters the large intestine to change the gut microbiota, resulting in abnormal lipid metabolism. Fructose metabolism as described in biochemistry textbooks is in need of a major change. In this symposium, we would like to explain the latest findings on sucrose and fructose metabolism, and discuss how the textbooks of biochemistry should be changed in the future with many audiences.
3S13m
Date:November 11th 9:00-11:00 Place: Room 13（431）
Frontiers in pathobiochemistry of axonal injury and intractable neuropathies
organizer:
Kazunori Sango（Diabetic Neuropathy Project, Tokyo Metropolitan Institute of Medical Science)
Junji Yamauchi（Laboratory of Molecular Neurology, Tokyo University of Pharmacy and Life Sciences)
Yumi Terashima（Department of Biotechnology, Maebashi Institute of Technology)
Junji Yamauchi（Laboratory of Molecular Neurology, Tokyo University of Pharmacy and Life Sciences)
Shizuka Takaku（Diabetic Neuropathy Project, Tokyo Metropolitan Institute of Medical Science)
Ayako Kato（Laboratory of Medicine, Aichi Gakuin University School of Pharmacy)
Junji Yamauchi（Laboratory of Molecular Neurology, Tokyo University of Pharmacy and Life Sciences)
Shizuka Takaku（Diabetic Neuropathy Project, Tokyo Metropolitan Institute of Medical Science)
Ayako Kato（Laboratory of Medicine, Aichi Gakuin University School of Pharmacy)
In the peripheral nervous system, the intrinsic regenerative capacity of neurons coupled with Wallerian degeneration and subsequent effective debris elimination system contributes to axonal regeneration and remyelination after injury. However, the molecules and mechanisms involved in the repair process remain unclear, and clinical trials for axonal regeneration have not achieved successful functional recovery. In addition, peripheral neuropathies caused by various etiologic mechanisms (e.g., Charcot-Marie-Tooth diseases, chemotherapy-induced neuropathy, and diabetic polyneuropathy) are intractable, and effective remedies for them have not been developed. This symposium focuses on recent topics regarding the pathobiochemistry of axonal injury and neuropathies and cutting-edge approaches to these lesions using novel neuroprotective molecules (e.g., oxidized galectin-1, zonisamide, exenatide, and imeglimin).
3S14m
Date:November 11th 9:00-11:00 Place: Room 14（432）
Current topics and future perspectives of studies on protein structural dynamics
organizer:
Norimichi Nomura（Kyoto University)
Shigeki Kiyonaka（Nagoya University)
sponsor:
MEXT Grant-in-Aid for Scientific Research on Innovative Areas "Non-equilibrium-state molecular movies and their applications (Molecular Movies)"
Eriko Nango（Tohoku University)
Tomohiro Nishizawa（Yokohama City University)
Ichio Shimada（RIKEN)
Minoru Kubo（University of Hyogo)
Shigeki Kiyonaka（Nagoya University)
Osamu Miyashita（RIKEN)
So Iwata（Kyoto UNiversity)
Tomohiro Nishizawa（Yokohama City University)
Ichio Shimada（RIKEN)
Minoru Kubo（University of Hyogo)
Shigeki Kiyonaka（Nagoya University)
Osamu Miyashita（RIKEN)
So Iwata（Kyoto UNiversity)
The structure, movement, and assembly/disassembly of biomolecules are involved in the elementary processes of various biological functions. In this symposium, we will present current studies on protein structural dynamics, including time-resolved serial femtosecond crystallography using X-ray free electron laser, cryo-electron microscopy, high-resolution NMR and microspectroscopy. In addition to this actual observation of structural transitions, collaborations with chemical biology and computational simulations to control, understand and predict the structural dynamics will be presented. Finally, we will discuss the future direction of “correlative structural studies of protein dynamics” to combine these multiple different approaches.
3S15m
Date:November 11th 9:00-11:00 Place: Room 15（131+132）
Diverse proteolytic mechanisms involved in the initiation, continuation, and termination of intracellular signaling
organizer:
Koh Nakayama（Asahikawa Medical University)
Kyoko Shirakabe（Ritsumeikan University)
Kyoko Shirakabe（Ritsumeikan University)
Shusuke Taniuchi（Asahikawa Medical University)
Hideki Yashiroda（University of Tokyo)
Aya Noguchi（Tokyo Metropolitan Institute for Medical Science)
Miki Yokoyama（Tokyo Medical and Dental University)
Yoji Minamishima（Gunma University)
Takayuki Kadoya（Hiroshima University)
The environment in which cells exist (temperature, pressure, pH, oxygen concentration, etc.) changes dynamically. The cell senses these changes and activates intracellular signaling pathways to trigger physiological responses appropriate to the environment. On the other hand, the activated signaling pathways need to be terminated after a certain period of time. Post-translational modifications of proteins, such as phosphorylation, are involved in the regulation of signaling pathways in the cell. In this symposium, we would like to focus on proteolysis, which acts at each step of signaling in response to environmental changes, from initiation to termination, and discuss its various modes and physiological responses.
3S16m
Date:November 11th 9:00-11:00 Place: Room 16（133+134）
Intra- and Extra-cellular environment involved in cellular function and disease
organizer:
Yoshito Yamashiro（University of Tsukuba)
Eisuke Itakura（Chiba University)
Tomoyuki Nakamura（Kansai Medical University)
Fumi Kano（Tokyo Institute of Technology)
Ryo Ushioda（Kyoto Sangyo University)
Hiroyuki Matsumura（Tokyo Medical and Dental University)
Kiyoshi Hirahara（Chiba University)
Reiko Tajiri（The University of Tokyo)
Eisuke Itakura（Chiba University)
Fumi Kano（Tokyo Institute of Technology)
Ryo Ushioda（Kyoto Sangyo University)
Hiroyuki Matsumura（Tokyo Medical and Dental University)
Kiyoshi Hirahara（Chiba University)
Reiko Tajiri（The University of Tokyo)
Eisuke Itakura（Chiba University)
The extracellular matrix (ECM) has been widely recognized for its role as structural support for tissues and cells. Recent studies have shown that the function of cells and tissues can be regulated through dynamic replacements in the ECM environment, such as the secretion and spatiotemporal arrangement of the ECM, its reuptake, and degradation. However, the details of the changes in the turnover of the intracellular and extracellular regulations are not well understood yet. In this symposium, researchers with expertise in each stage of ECM secretion, construction, and degradation, as well as in the regulation of cellular functions, will gather to discuss the latest topics in cell-cell interaction, its impact on cell function, and diseases caused by its disruption. This session also aims to discuss various viewpoints with the audience, and we hope that it will lead to the next cutting-edge research and analysis methods to understand dynamic changes in the ECM environment.
Talks(Oral Presentation from Poster)&Posters
The schedule and titles of the presentations are available on the ”Program search / Abstract browsing system” in the website
Late-breaking Abstracts
The papers submitted as Late-breaking Abstracts are available on the “Program search / Abstract browsing system” on the website
(They are not included in the printed Program booklets.)
Bio Industry Seminar
1BS01
Date:November 9th 12:20-13:10 Place:Room 2（141＋142）
Co-sponsored：Shimadzu Corporation
Chairperson: Jun Watanabe (Shimadzu Corporation)
Introduction Reduction Technology of adsorption to metal using a Bio-inert UHPLC system "Nexera XS inert"
Yusuke Osaka (Shimadzu Corporation)
We have developed a bio-inert UHPLC system, “Nexera XS inert,” which uses non-metallic materials in contact with the sample. In this presentation, the analysis of metal-adsorbing compounds by Nexera XS inert and the cleaning mechanism of the autosampler will be introduced.
Introduction of sulfur metabolism profiling method using LC/MS
2BS01
Date:November 10th 12:20-13:10 Place: Room 2（141＋142）
Co-sponsored：SCIEX
Identification of post-translational modifications, peptides, and bioactive small molecules using new techniques in mass spectrometry.
Ushio Takeda
The advent of new mass spectrometry techniques has taken our understanding of molecules in all fields to the next level. Electron Activated Dissociation (EAD) is a technique that can provide information on a variety of targets that cannot be obtained by conventional dissociation methods. For example, it can provide evidence for the position of post-translational modifications in proteins, sequence confirmation of free peptides, or the position of double bonds in lipids, information that has been difficult to obtain using conventional mass spectrometry. In this seminar, the principles of this new technology and its applications will be explained in an easy-to-understand manner.
The 95th Annual Meeting of the Japanese Biochemical Society Secretariat
Hitotsubashi Bekkan 4F, 2-4-4, Hitotsubashi, Chiyoda-ku, Tokyo 101-0003 , JAPAN
(c/o A & E Planning, Co., Ltd)
TEL：+81-3-3230-2744 FAX：+81-3-3230-2479
E-mail：jbs2022@aeplan.co.jp
Hitotsubashi Bekkan 4F, 2-4-4, Hitotsubashi, Chiyoda-ku, Tokyo 101-0003 , JAPAN
(c/o A & E Planning, Co., Ltd)
TEL：+81-3-3230-2744 FAX：+81-3-3230-2479
E-mail：jbs2022@aeplan.co.jp
Head Office of the Japanese Biochemical Society
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TEL：+81-3-3815-1913 FAX：+81-3-3815-1934
E-mail：jbs-ho@jbsoc.or.jp
25-16 Hongo 5-chome, Bunkyo-ku, Tokyo 113-0033, Japan
TEL：+81-3-3815-1913 FAX：+81-3-3815-1934
E-mail：jbs-ho@jbsoc.or.jp
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