Program
May 25
8:20-8:30
Opening Remarks
8:30-11:00
Symposium 1 Disease-associated Macrophages
| Chair | Hiromitsu Hara (Kagoshima Univ.) Makoto Tsuda (Kyushu Univ.) |
| S1-1 | TREM2 in Neurodegeneration and Cancer |
| Marco Colonna (Washington Univ. USA) | |
| S1-2 | Unraveling the Heterogeneity of Antigen-Presenting Cells in Inflammatory Skin Diseases Using Single-Cell RNA Sequencing |
| Satoshi Nakamizo (Kyoto Univ.) | |
| S1-3 | Identification of a novel subset of macrophages that regulate muscle regeneration |
| Yumiko Ohishi (Nippon Med. Sch.) | |
| S1-4 | A new mechanism for pain chronicity revealed by a microglial subset |
| Makoto Tsuda (Kyushu Univ.) | |
| S1-5 | The power of ONE: Immunology in the age of single cell genomics |
| Ido Amit (Weizmann Institute of Science, Israel) |
11:20-12:50
General Assembly & JSICR Award Lecture
MMCB General Assembly
JSICR General Assembly
JSICR Award Lecture
JSICR General Assembly
JSICR Award Lecture
13:00-15:30
Symposium 2 Monogenic Disorders as Immune Rosetta Stone
| Chair | Kensuke Miyake（The Univ. of Tokyo） Tsuneyasu Kaisho（Wakayama Med. Univ.） |
| S2-1 | Human inborn errors of immunity model mice for autoinflammation,autoimmunity and/or immunodeficiency |
| Tsuneyasu Kaisho（Wakayama Med. Univ.） | |
| S2-2 | Immunodeficiency and autoinflammation caused by dysfunction of immunoproteasomes |
| Koji Yasutomo（Tokushima Univ.） | |
| S2-3 | Autoinflammatory disease due to G-CSF |
| Seth Masters (WEHI, Australia) | |
| S2-4 | The molecular mechanism underlying STING degradation at lysosomes |
| Tomohiko Taguchi（Tohoku Univ.） | |
| S2-5 | Lysosomal nucleic acid stress diseases |
| Kensuke Miyake（The Univ. of Tokyo） |
15:40-16:40
Workshop 1 Innate Immune Cells in Health and Disease
| Chair | Osamu Takeuchi (Kyoto Univ.) Taro Kawai (NAIST) |
| WS1-1 | Endosomal abnormalities in dendritic cells cause autoimmune hepatitis and primary biliary cholangitis |
| Shin-Ichiroh Saitoh (The Univ. of Tokyo) | |
| WS1-2 | Semaphorin 7A promotes neutrophil activation and neutrophil extracellular trap formation |
| Shoji Kawada (Osaka Univ.) | |
| WS1-3 | A stress sensor IRE1α is involved in bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages |
| Izumi Sasaki (Wakayama Med. Univ.) | |
| WS1-4 | The Regnase-1/3-Nfkbiz axis controls hematopoietic lineage priming |
| Takuya Uehata (Kyoto Univ.) | |
| WS1-5 | Myeloid-like B cells protect the host by boosting myelopoiesis during infection |
| Masashi Kanayama (TMDU) | |
| WS1-6 | Microglia activation by β-GlcCer causes phagocytosis of neurons that exacerbates Gaucher disease |
| Takashi Shimizu (Osaka Univ.) | |
| WS1-7 | Antigen cross-presentation by Alveolar macrophages during viral infection |
| Takumi Kawasaki (Nagasaki Univ.) |
16:50-17:50
Workshop 2 Advances in Cytokine Research for Disease Pathophysiology
| Chair | Akinori Takaoka (Hokkaido Univ.) Hiroki Yoshida (Saga Univ.) |
| WS2-1 | Suppression of itch sensation by IL-27 |
| Daiji Sakata (Kagoshima Univ.) | |
| WS2-2 | CD8+ T-cell memory induced by SARS-CoV-2 mRNA vaccination is maintained by clonal replenishment |
| Satoshi Ueha (Tokyo Univ. of Sci.) | |
| WS2-3 | The role of inflammatory cytokines in B-ALL development |
| Aisa Suzuki (Tokyo Univ. of Sci.) | |
| WS2-4 | Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation |
| Ken Takashima (Kumamoto Univ.) | |
| WS2-5 | Impaired plasma cell generation in a model mouse of the proteasome-associated autoinflammatory syndromes with immunodeficiency |
| Takashi Kato (Wakayama Med. Univ.) | |
| WS2-6 | Comprehensive mapping of extracellular particles during viral infection by high esolution flow cytometry |
| Tomoya Hayashi (IMSUT / VDesc / NIBIOHN) |
18:00-19:30
Poster Viewing
May 26
9:00-11:00
Symposium 3 The Forefront of Covid-19 Research
| Chair | Yumiko Imai (NIBIOHN) Hiroyuki Oshiumi (Kumamoto Univ.) |
| S3-1 | ACE2- at the heart of a pandemic |
| Josef Penninger (Univ. British Columbia, Canada) | |
| S3-2 | Therapeutic effects of angiotensin converting enzyme 2 (ACE2) enzyme activity on severe acute lung injury in COVID-19 |
| Keiji Kuba (Kyushu Univ.) | |
| S3-3 | Mechanisms of severe disease and sequelae and potential for drug discovery – Medical big data and basic analysis |
| Yumiko Imai (NIBIOHN) | |
| S3-4 | Unusual type I interferons are associated with cholesterol metabolism and prime the antiviral innate immune response |
| Hiroyuki Oshiumi (Kumamoto Univ.) |
11:20-12:20
Luncheon Seminar (Co-sponsored by Sanofi)
| Chair | Yoshiki Tokura (Chutoen General Medical Center) |
| LS-1 | The role of group 2 innate lymphoid cells in ulcerative colitis |
| Kazuyo Moro (Osaka Univ.) | |
| LS-2 | Regulation of type 2 inflammation as a therapeutic approach for atopic dermatitis |
| Tetsuya Honda (Hamamatsu Univ. Sch. Med.) |
12:30-13:30
Afternoon Seminar (Co-sponsored by Bristol-Myers Squibb K.K.)
| Chair | Atsushi Otsuka (Kinki Univ.) |
| AS-1 | New treatment strategy for psoriasis ~Deucravacitinib, an oral selective TYK2 inhibitor~ |
| Masahiro Kamata (Teikyo Univ.) |
| Chair | Nobuo Kanazawa (Hyogo Med. Univ.) |
| AS-2 | Roles of the IL-23-IL-17A/F axis in the development of psoriasis |
| Yoichiro Iwakura (Tokyo Univ. of Sci.) |
13:40-15:40
Symposium 4 Imaging of Immune Cells Interaction
| Chair | Kenji Kabashima (Kyoto Univ.） Takaharu Okada (RIKEN IMS) |
| S4-1 | Probing Tissue Macrophage functions in Health and Disease |
| Steffen Jung (Weizmann Institute of Science, Israel） | |
| S4-2 | Newly identification of a CXCR6+ pathogenic skin-resident CD4+ T cell subset in a mouse model of allergic dermatitis that requires CXCL16 for its maintenance |
| Kenji Kabashima (Kyoto Univ.） | |
| S4-3 | Spatiotemporal development of dendritic cell networks |
| Wolfgang Kastenmüller (Universitat Wurzburg, Germany) | |
| S4-4 | The role for sensory neuronal IL-31 receptor and STAT3 in inflammatory itch |
| Takaharu Okada (RIKEN IMS) |
15:40-15:50
Poster Award Ceremony
15:50-16:00
Closing Remarks