日本生理学会　第100回記念大会

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Program

At a Glance
Program
LBA
High School Students Presentation

Plenary lectures

Shinya Yamanaka

  • The Nobel Prize in Physiology or Medicine 2012 laureate
Center for iPS Cell Research and Application, Kyoto University.
Recent Progress in iPS Cell Research and Application
Date：Mar. 14　11:10-12:10
Place：Room 1

Svante Pääbo

  • The Nobel Prize in Physiology or Medicine 2022 laureate
*Online Presentation
Max Planck Institute for Evolutionary Anthropology
Archaic Genomics
Date：Mar. 15　11:10-12:10
Place：Room 1

Bente Klarlund Pedersen

*Online Presentation
The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen
Exercise as Medicine in a translational perspective
Date：Mar. 16　11:10-12:10
Place：Room 1

Future of Life Science, Future of Human Beings----Dialogue between Nobel Prize Laureates

Date&Time: 17:30-18:30, March 14, 2023

S. Hagiwara Memorial Lecture

Masanobu Kano

Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo

Formation of mature neural circuits through activity-dependent synapse pruning
Date：Mar. 16　14:20-15:20
Place：Room 1

S. Tawara Memorial Lecture

Yasuhiko Minokoshi

Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences

Hypothalamic regulation of fat and carbohydrate metabolism
Date：Mar. 15　14:20-15:20
Place：Room 1

Special Lectures

Sidonia Fagarasan

Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences

A novel B cell-derived metabolite elicits anti-inflammatory macrophages and limits anti-tumor cytotoxic responses
Date：Mar. 14　14:20-15:20
Place：Room 1

Hideyuki Okano

Keio University

iPSCs-based Regenerative Medicine and Drug Development of CNS disorders
Date：Mar. 14　15:30-16:20
Place：Room 1

Mitinori Saitou

Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University

Mechanism and In Vitro Reconstitution of Mammalian Germ-Cell Development
Date：Mar. 15　15:30-16:20
Place：Room 1

Hiroki R. Ueda

1. Systems Pharmacology, Graduate School of Medicine, University of Tokyo
2. Laboratory for Synthetic Biology, Center for Biosystems Dynamics Research, RIKEN

Towards Systems Biology of Human Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep
Date：Mar. 16　15:30-16:20
Place：Room 1

Symposia

1AS01m
Committee for 100th anniversary

Homeostasis for sustainability –Toward the next century of physiological sciences-

Date：Mar. 14　9:00-11:00　Place：Room 1
Orgnizers:
Yoshinori Marunaka (Kyoto Industrial Health Association)
Tadashi Isa (President, The 100th Anniversary Meeting of PSJ)

Susan Wray (IUPS President / FEPS President, UK)
Robyn Murphy (AuPS President, Australia)
Chae Hun Leem (FAOPS President / KPS President, Korea)
Dee U. Silverthorn (APS President, USA)
Yoshihiro Ishikawa (PSJ President, Japan)

1AS02a

Neurobiology of the social brain

Date：Mar 14　14:20 - 16:20　Place：Room 2
Organizer：
Mariko Miyata（Tokyo Women's Medical University, School of Medicine）
Tomoyuki Furuyashiki（Kobe University Graduate School of Medicine）
Kumi Kuroda（Lab for affiliative social behavior, Riken Center for Brain Science）
Aki Takahashi（Faculty of Human Sciences, University of Tsukuba）
Toru Takumi（Kobe University School of Medicine）
Taihei Ninomiya（National Institute for Physiological Sciences）
Makiko Yamada（National Institutes for Quantum Science and Technology）
Social isolation has become a severe social problem due to the recent COVID19 disaster. Proper social experience in early childhood and adolescence significantly impacts humans’ lifelong personality formation, emotional stabilization, and social acquisition. These are also closely related to social issues such as abuse, neglect, and withdrawal. Social stress also affects various brain functions. On the other hand, neuroscience studies recently reveal the neural circuits for social acquisition, the mechanism of effect on brain function caused by social isolation, and the pathophysiology of neurodevelopmental disorders. This symposium aims to provide a cross-sectional and multifaceted understanding of social neuroscience from rodents to humans.
1S03a
International Relations Committee

Dynamics & homeostasis of organella/cellular function

Date：Mar 14　14:20 - 16:20　Place：Room 3
Co-hosted by：FAOPS-PSJ Joint Symposium
Organizer：
Motohiro Nishida（Kyusyu University Graduate School of Pharmacy, Department of Physiology/National Institute for Physiological Sciences, Division of Cardiocirculatory Signaling）
Chae Hun Leem（University of Ulsan College of Medicine(Korea), Department of Physiology）
Yong Zhang（Harbin Medical University (China), College of Pharmacy, Department of Pharmacology）
Satoshi Matsuoka（University of Fukui, Faculty of Medical Sciences, Department of Integrative and Systems Physiology）
Chae Hun Leem（University of Ulsan College of Medicine(Korea), Department of Physiology）
Motohiro Nishida（Kyusyu University Graduate School of Pharmacy, Department of Physiology / National Institute for Physiological Sciences, Division of Cardiocirculatory Signaling）
1S04a

Physiological approach to elucidate the behavioral basis-Toward the next century of physiology-WPJ Sponsored Symposium

Date：Mar 14　14:20 - 16:20　Place：Room 4
Organizer：
Akiko Arata（Department of Physiology, Hyogo Medical University）
Tamami Nakano（Graduate School of Frontiers Bioscience, Osaka University）
Sachine Yoshida（Faculty of Medicine, Toho University）
Miho Nagasawa（ Azabu University School of Veterinary Medicine）
Shizuko Hiryu（Doshisha University）
Aiko Murata（NTT Communication Science Laboratories）
Tamami Nakano（Graduate School of Frontiers Bioscience, Osaka University）
In the next century of physiology, female researchers should participate more in physiology and physiology will elucidate the bases of behavior. We propose the symposium by five female speakers, including speakers from other academic societies, who elucidate the communication as ethology from a behavioral viewpoint. Dr. Yoshida talks “physiological changes of mother-child relationship caused by contact” Dr. Nagasawa talks “social cognition and behavior of dogs acquired by domestication” Dr. Murata talks “emotions that change through interaction with others”, Dr. Hiryu talks “sound communication in echolocation of bats” and Dr. Nakano talks “conscious and subconscious neural processing in images of self and others”. This symposium is assisted by Women in Physiology of Japan (WPJ), which supports the active participation of women.
1AS05a
Committee for Young Physiologists

Discussion for the future of physiological sciences

Date：Mar 14　14:20 - 16:20　Place：Room 5
Organizer：
Daisuke Yamada（Tokyo University of Science）
Yuki Suda（University of Yamanashi）
Daisuke Yamada （Tokyo University of Science）
Yuki Suda（University of Yamanashi）
Many academic societies are trying to foster young researchers who will lead the future of scientific research in Japan, but in principle, they often targeted at undergraduate students and above. On the other hand, we often hear undergraduate students say that they had an interest in scientific research and motivation to become a scientist even before entering university. Therefore, in this symposium, we will invite high school students and try to discuss the future of physiological science in Japan with undergraduate students and members of the PSJ youth group. By holding it as a convention plan, not as a regular event sponsored by the PSJ youth group, we would like to provide the young people with experience of attending an academic conference and create a starting point for revitalizing the PSJ.
1S06a
Cooperation with Other Societies Committee

New Era of Sensory Neuroscience

Date：Mar 14　14:20 - 16:20　Place：Room 6
Co-hosted by: The Japanese Pharmacological Society / AMED-CREST/PRIME MultiSensing / JST-CREST MultiSensing
Organizer：
Hiroshi Hibino（Graduate School of Medicine, Osaka University）
Makoto Tsuda（Graduate School of Pharmaceutical Sciences, Kyushu University）
Takeru Ota（Graduate School of Medicine, Osaka University）
Akiyuki Taruno（Kyoto Prefectural University of Medicine）
Takeshi Imai（Graduate School of Medical Sciences, Kyushu University）
Yuta Koro（Graduate School of Pharmaceutical Sciences, Kyushu University）
Sensation plays key roles in regulation of the homeostasis and various actions as well as associates with different brain functions including emotion. In elderly, healthy life-expectancy is shortened by sensory disorders. Each sensation depends on a specialized peripheral organ and unique nervous systems. Recent technological advances allow the researchers to reveal the molecular architecture of the receptors, the machineries of the encoding, the neuronal networks, and the decoding processes, in individual sensations. On the basis of these backgrounds, in this symposium the leading scientists studying hearing, taste, olfaction, or pain will show their recent findings in the operation principles, pathophysiology, possible therapies, and discuss the next-generation strategies exploring the sensory neuroscience.
1S07a

Neurobiology of addiction science

Date：Mar 14　14:20 - 16:20　Place：Room 7
Organizer：
Katsuyuki Kaneda（Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University）
Yuko Sekino（Institute for Drug Discovery Innovation）
Yuko Sekino（Institute for Drug Discovery Innovation）
Soichiro Ide（Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science）
Naoya Nishitani（Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University）
Tom Macpherson（Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University）
Ryo Sasaki（Division of Physiology and Neurobiology, Department of Neuroscience, Graduate School of Medicine, Kyoto University）
Addictions, including drug addiction to methamphetamine and narcotics and behavioral addictions to smartphones, the Internet, and video games, have become major social problems. Previous studies suggested that the activity and plastic changes in the brain reward system consisting of projection from the ventral tegmental area to the nucleus accumbens are important in the pathophysiology of addiction, but detailed molecular mechanisms remain unclear. In this symposium, we would like to introduce the latest findings aimed at understanding the pathophysiology of addiction using nematodes, rodents, and non-human primates, and discuss the social situation surrounding addiction and the future prospects of addiction research.
1S08a

A challenge from physiology for exercise medicine: scientific evidence and its social implementation

Date：Mar 14　14:20 - 16:20　Place：Room 8
Co-hosted by：The Japanese Society of Physical Fitness and Sports Medicine
Organizer：
Shizue Masuki（Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine）
Keiichi Higuchi（Community Health Care Research Center, Nagano University Health and Medicine）
Qi Fu（University of Texas Southwestern Medical Center, Dallas）
Kristian Karstoft（University of Copenhagen, Copenhagen, Denmark）
Keiichi Higuchi（Community Health Care Research Center, Nagano University Health and Medicine）
Shizue Masuki（Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine）
The rapid rise in healthcare costs with rapidly growing elderly populations has highlighted the importance of exercise training for therapeutic as well as preventive medicine. The goal of this symposium is to review and discuss scientific evidence and social implementation of exercise training programs in clinical medicine, together with physiological and molecular mechanisms.In the symposium, Dr Fu will present data on the impact of exercise training in cardiovascular disease patients with physical deconditioning. Dr Karstoft will present data on the effects of exercise training in type 2 diabetic patients. Dr Higuchi will present the molecular mechanisms for training-induced improvements of age-associated disease symptoms in mice. Dr Masuki will propose a possible implementation of exercise training for clinical medicine.
1S09a

Circadian Rhythm in Health and Disease

Date：Mar 14　14:20 - 16:20　Place：Room 9
Organizer：
Yujiro Yamanaka（Laboratory of Life and Health Sciences, Graduate School of Education, Hokkaido University）
Naohiro Kon（Institute of Transformative Bio-Molecules (ITbM), Nagoya University）
Kon Naohiro（Institute of Transformative Bio-Molecules (ITbM), Nagoya University）
Nobuya Koike（Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine）
Keiko Tominaga（Osaka University）
Yujiro Yamanaka（Laboratory of Life and Health Sciences, Graduate School of Education, Hokkaido University）
Sato Honma（Sapporo Hanazono Hospital）
The circadian clock system is a physiological strategy to anticipate an environmental light-dark cycle and integrate the temporal order of behavior and physiological function in the organism. Chronobiological research has studied various aspects of the circadian system from the cellular and molecular basis of clock construction in vitro to behavioral and physiological clock functions in vivo. These studies have revealed that circadian rhythms are closely associated with our health and disease. In this symposium, we introduce a recent advance in the field of chronobiology research including the molecular clock system, circadian rhythms in diurnal non-human primates, and circadian rhythms in humans.
2AS01m

The Future of Science Driven by Cross-Disciplinary Projects

Date：Mar 15　9:00 - 11:00　Place：Room 1
Co-hosted by：Science Council of Japan
Organizer：
Hiroki Ueda（Department of Systems Pharmacology, Faculty of Medicine, The University of Tokyo）
Satomi Adachi-Akahane （Department of Physiology, Faculty of Medicine, Toho University）
Masayuki Yamamoto（Tohoku University Tohoku Medical Megabank Organization）
Yoshinobu Baba（National Institutes for Quantum and Radiological Science and Technology）
Masaki Takata（Photon Science Innovation CenterInternational Center for Synchrotron Radiation Innovation Smart, Tohoku University）
Yoichi Minami（Department of Systems Pharmacology, Faculty of Medicine, The University of Tokyo）
In science, project-based research has been a driving force in next-generation research. In biology and medicine, project-based research has been strongly promoted, as exemplified by the Human Genome Project, and has contributed to the establishment of research infrastructure and new research concepts that will contribute to the next generation of science. In Japan, large-scale research projects are also being implemented, contributing to the infrastructure of the research community, challenging the development of new methodologies, and attempting to integrate basic science, social science, and clinical science beyond the conventional framework. In this symposium, project leaders representing Japan will discuss the aims of their projects from a macro perspective and introduce cutting-edge research realized through project-based research.
2S02m

Current perspective of hibernation and torpor in mammals

Date：Mar 15　9:00 - 11:00　Place：Room 2
Co-hosted by：Transformative Research Areas(B) HIBERNATION BIOLOGY
Organizer：
Yoshifumi Yamaguchi（Institute of Low Temperature Science, Hokkaido University）
Takeshi Sakurai（International Institute for Integrative Sleep Medicine(IIIS)）
Yoshifumi Yamaguchi（Institute of Low Temperature Science, Hokkaido University）
Ryosuke Enoki（ExCELLs, National Institute of Physiological Sciences, National Institute of Natural Sciences）
Elena Gracheva（Yale University）
Takeshi Sakurai（International Institute for Integrative Sleep Medicine(IIIS)）
Genshiro Sunagawa（Riken BDR）
Mammalian hibernation is an adaptive strategy to survive in cold environments with seasonal decreases in food availability. Hibernation in small mammalian hibernators, including ground squirrels and hamsters, consists of multiple cycles of normothermic arousal phase and multiday hypothermic torpor phase characterized by the profound suppression of metabolism, body temperature, heart rate, food intake, and locomotive activity. Some mammals including mice do not hibernate in a season-dependent manner but adapt torpor as a response to unpredictable fasting. Mechanisms that enable hibernation and torpor are still poorly understood. The aim of this symposium is to bring the latest knowledge of hibernation and torpor from different perspectives in several species to a broad audience.
2S03m

Physiology in the kidney revisited

Date：Mar 15　9:00 - 11:00　Place：Room 3
Co-hosted by：Japanese Society of Nephrology
Organizer：
Motoko Yanagita（Kyoto University Graduate School of Medicine）
Tsuyoshi Inoue（Department of Physiology of Visceral Function and Body Fluid ）

Shinya Yamamoto（Kyoto University Graduate School of Medicine）
Tetsuro Kusaba（Kyoto Prefectural University of Medicine）
Seiji Kishi（Kawasaki Medical School）
Kaori Hayashi（Keio University）
Tsuyoshi Inoue（Nagasaki University）

Physiological studies using isolated nephrons have been a very important area of nephrology, but in recent years such classical physiological studies have become less common. On the other hand, ‘new physiology’, using new techniques such as imaging, is bringing new perspectives to nephrology.With this perspective in mind, we nominate five young researchers from Japanese Society of Nephrology. We hope that this symposium will lead to joint research between members of the Japanese Society of Nephrology and the Physiological Society of Japan.
2S04m

Cellular senescence: its role in organ homeostasis and life span

Date：Mar 15　9:00 - 11:00　Place：Room 4
Organizer：
Naoko Ohtani（Graduate School of Medicine, Osaka Metropolitan University）
Aiko Sada（International Research Center for Medical Sciences (IRCMS)）
Makoto Nakanishi（The Institute of Medical Science, The University of Tokyo）
Aiko Sada（International Research Center for Medical Sciences (IRCMS)）
Tohru Minamino（Juntendo University, Cardiology）
Ryota Yamagishi（Graduate School of Medicine, Osaka Metropolitan University）
Eiji Hara（Research Institute for Microbial Diseases）
Cellular senescence is a state of irreversible cell cycle arrest induced by a variety of cellular stresses. Hence, senescence has been considered as a guardian of homeostasis. However, recent studies have revealed that long-term senescent cells promote the secretion of a series of inflammatory cytokines, chemokines, and this phenotype is termed as senescence-associated secretory phenotype (SASP) that are associated with aging-associated diseases. Recently, the strategies to eliminate senescent cells (senolysis) targeting the vulnerability of senescent cells has shown to induces extension of a healthy life span and improvement of cancer. Thus, further studies for the control of senescent cells will open up possibilities to ameliorate senescence-associated diseases toward healthy longevity.
2S05m

Neurophysiology in the big data era: uncovering ultra-complex emotion circuits connecting self and others

Date：Mar 15　9:00 - 11:00　Place：Room 5
Co-hosted by：Grant-in-Aid for Transformative Research Areas(B): The science of envy
Organizer：
Masakazu Agetsuma（National Institute for Physiological Sciences）
Atsushi Kasai（Graduate School of Pharmaceutical Sciences, Osaka University）
Masakazu Agetsuma（National Institute for Physiological Sciences）
Ziyan Huang（Institute for quantitative biosciences (IQB)/ Graduate school of medicine, the University of Tokyo）
Atsushi Noritake（Division of Behavioral Development, National Institute for Physiological Sciences）
Atsushi Kasai（Graduate School of Pharmaceutical Sciences, Osaka University）
Kazunari Miyamichi（RIKEN Center for Biosystems Dynamics Research (BDR)）
People in the world, through the COVID-19 era, have come to reaffirm the importance of the connection between individuals. The brain regulates the underlying “recognition of self and others” and the resulting social interaction, by processing multidimensional information including sensory information from the external environments and temporal components such as memory and prediction. This symposium introduces the ambitious interdisciplinary studies, based on data-driven and computational approaches combined with cutting-edge methods generating big data, such as next-generation whole-brain-wide anatomy, and large-scale recording and fine manipulation of neural activity. These approaches enable the dissection of the ultra-complex computational architecture underlying social interactions, encouraging the next 100 years of neurophysiology.
2S06m

Changing Trends in Gastrointestinal Research: From Molecules and Cells to Organisms

Date：Mar 15　9:00 - 11:00　Place：Room 6
Organizer：
Akira Ikari（Gifu Pharmaceutical University）
Hisayoshi Hayashi（University of Shizuoka）
Takuto Fujii（University of Toyama）
Yuta Yoshino（Gifu Pharmaceutical University）
Hiroyuki Miyoshi（Kyoto University）
Wendy Hempstock（University of Shizuoka）
Yoshimasa Saito（Keio University）
The intestinal epithelium separates the internal from the external milieu with its barrier function. This compartmentalization allows the intestine to various functions in the organism. Intestinal stem cells (ISC) differentiate into various epithelial cells, and remodeling the intestinal epithelium in order to preserve homeostasis. Epithelial cell function derives from having two distinct plasma membranes, in which different transporters are expressed. However, their functions and regulations remain unknown. Furthermore, an organism’s homeostasis is disrupted by the oncogenic effects of ISCs due to aging and functional loss. In this symposium, we hope to integrate the research at the molecular, cellular, and organism level and lead to the establishment of new cornerstones in intestinal physiology by linking research with innovation.
2S07m

Recent advances in the regulation of homeostasis by immune-vascular systems

Date：Mar 15　9:00 - 11:00　Place：Room 7
Organizer：
Rieko Muramatsu（National Center of Neurology and Psychiatry）
Toru Takumi（Kobe University Graduate School of Medicine）
Rieko Muramatsu（National Center of Neurology and Psychiatry）
Miho Shirator-Hayashi（Faculty of Pharmaceutical Sciences Kyushu University）
Yasutaka Okabe（Osaka University Immunology Frontier Research Center）
Hisamichi Naito（Kanazawa University Graduate School of Medicine）
Yukako Oda（Institute for Frontier Life and Medical Sciences, Kyoto University）
The maintenance of homeostasis under normal physiological conditions is regulated by the immunological response and vascular function, and this regulation is affected by the change of each systems’ status. The heterogeneity of the inflammatory cells and vascular cells contribute to the homeostasis at the cellular and biological function, and these cellular characteristics are affected during development and aging. In this symposium, we will provide the recent findings about the novel mechanism that controls the immune and vascular system itself, and unveil the role of each system that affects the cellular and biological level.
2S08m
Cooperation with Other Societies Committee

Coordination of visceral organ functions: Basic and clinical aspects

Date：Mar 15　9:00 - 11:00　Place：Room 8
Co-hosted by：Japan Society of Neurovegetative Research
Organizer：
Mieko Kurosawa（Foundation for Advancement of International Science）
Naoto Hara（International University of Health and Welfare, Department of Orthoptics and Visual Sciences）
Yusaku Iwasaki（Graduate School of Life and Environmental Sciences, Kyoto Prefectural University）
Fusako Kagitani（University of Human Arts and Sciences, Graduate School and Department of Human Ars and Sciences）
Eiichiro Nagata（Department of Neurology, Tokai University School of Medicine）
Naoto Hara（International University of Health and Welfare, Department of Orthoptics and Visual Sciences）
Autonomic (visceral) function is constantly regulated reflexively by afferent information from visceral organs. This visceral afferent information, which is the basis of autonomic regulation, is also involved in the coordination between various visceral organ functions. Autonomic function is regulated not only by visceral afferent nerves but also by somatosensory nerves, and the somato-autonomic responses are a part of mechanism in the effects of rehabilitation and acupuncture. In addition, autonomic functions are regulated by inputs of special senses such as visual and auditory senses. In this symposium, the coordination of visceral organ functions will be discussed from a basic and clinical standpoint, focusing on visceral afferent input, somatosensory input, and visual input.
2S09m

Pericytes -Functional diversity and commonality in health and disease

Date：Mar 15　9:00 - 11:00　Place：Room 9
Organizer：
Hikaru Hashitani（Nagoya City University）
Christopher Garland（University of Oxford）
Koji Ando（National cerebral and cardiovascular center research institute）
Paolo Tammaro（University of Oxford）
Tetsuro Ago（Kyushu university）
Hikaru Hashitani（Nagoya City University）
Pericytes, mural cells that surround predominantly capillaries, play a range of fundamental roles spanning from the local control of blood flow to vasculo-angiogenesis. In the central nervous system, pericytes in cooperation with the endothelium, neurons and glial cells form a neurovascular unit that finely regulates local blood flow. In visceral organs, pericytes function as pacemaker cells driving spontaneous vasomotion. In addition, pericytes have a multipotency including the transition into fibroblast-like cells, and thus may have a critical role in tissue repair and functional recovery after ischemic stroke. The diversity and commonality of pericyte functions will be discussed, with a particular focus on their ion channels, their Ca2+-activated Cl- channels (TMEM16A), and ATP-sensitive K+ channels (KCNJ8/ABCC9).
2S10m

Distinguished Japanese contributions to The Journal of Physiology: past, present, future of physiology

Date: Mar 15 9:00-11:00 Place: Room 10
Co-hosted by: JP-PSJ joint symposium
Organizer:
Laura Bennet (Deputy Editor-in-Chief of J Physiol / University of Auckland)
Yoshihiro Kubo (Regional Editor of J Physiol / National Institute for Physiological Sciences)

Akimichi Kaneko (Keio University)
Kazue Mizumura (Department of Physiology, Nihon University School of Dentistry / Nagoya University)
Masaki Sakurai (Department of Physiology, Teikyo University School of Medicine)
Harunori Ohmori (Kyoto University)
Akinori Noma (Research Organization of Science and Technology, Ritsumeikan University)

2S02a
Committee for Research Ethics

Development and ethics of medical care and research - A review of the history of medical ethics in Japan

Date：Mar 15　15:30-16:20　Place：Room 2
Organizer：
Kenji Kansaku（Dokkyo Medical University）
Takanori Uka（University of Yamanashi）
Fumio Eto （Japan Academy for Comprehensive Rehabilitation）
2AS03a
Committee for 100th anniversary

AI technology pioneers a new era of medicine, physiology, and life sciences

Date：Mar 15　14:20 - 16:20　Place：Room 3
Organizer：
Dai Mitsushima（Department of Physiology, Yamaguchi University Graduate School of Medicine）
Noriko Takahashi（Department of Physiology, Kitasato University School of Medicine）

Gouhei Tanaka（International Research Center for Neurointelligence(IRCN), Institutes forAdvanced Study, The University of Tokyo）
Kenichi Ohki（The University of Tokyo Graduate School of Medicine, International Research Center for Neurointelligence, Institute for AI and Beyond）
Mariko Okada（Institute for Protein Research, Osaka University）
Takahiro Tanaka（Toshiba corporation, Research & development center, Advanced intelligent systems technology center, AI Application Dept.）

In commemoration of 100th anniversary of the Physiological Society of Japan, this symposium will introduce new aspects of research methods for the next 100 years. Artificial Intelligence (AI) technology is considered to be one of the important tools to break through to a new era of physiology. The speaker will present cutting-edge research on how the approach can be used to advance a wide range of fields, including neuroscience, cellular regulatory systems, and risk prediction for the onset of life-style related diseases.
2AS04a

Toward understanding the regulation of channel proteins by lipids or lipid-analogues and its importance in physiological context

Date：Mar 15　14:20 - 16:20　Place：Room 4
Co-hosted by：Sophion Bioscience KK
Organizer：
Takafumi Kawai（Graduate School of Medicine, Osaka University）
Masayuki Mori（School of Medicine, University of Occupational and Environmental Health）
Atsunori Oshima（Cellular and Structural Physiology Institute (CeSPI), Nagoya University）
Fredrik Elinder（Department of Biomedical and Clinical Sciences, Linköping University）
Masayuki Mori（School of Medicine, University of Occupational and Environmental Health）
Takaaki Sokabe（Division of Cell Signaling, National Institute for Physiological Sciences）
Takafumi Kawai（Graduate School of Medicine, Osaka University）
Recent advance in structure biology has allowed to precisely characterize the molecular function of channel proteins. On the other hand, these structures are sometimes solved with the binding lipids, indicating the importance of regulation by these molecules. This symposium aims to give the insight about regulation of channel proteins by lipids or the analogues and its physiological importance. We talk about gating machinery of large-pore forming channel in phospholipids, modulatory effect of the lipophilic compound on K+ channels, TRP channel regulation by phosphoinositides, ion channel regulation by lipid metabolite in Drosophila, and ion channel regulation by phosphoinositides in sperm. These talks range from structural to biological insights and strongly push the research field forward.
2S05a

New roles of hormones that contribute to glucoregulation and diabetes

Date：Mar 15　14:20 - 16:20　Place：Room 5
Organizer：
Sho Matsui（Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University）
Yoshio Fujitani（Laboratory of Developmental Biology & Metabolism Institute for Molecular & Cellular Regulation, Gunma University）
Yoshitaka Hayashi（Department of Endocrinology, Research Institute of Environmental Medicine, Nagoya University）
Pereye Ofejiro（Laboratory of Developmental Biology & Metabolism Institute for Molecular & Cellular Regulation, Gunma University）
Sho Matsui（Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University）
Tomonobu Hatoko（Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University）
Diabetes is a complex multifactorial disease. Drug development through understanding of its pathophysiology, and elucidation of the mechanism of action of existing drugs have helped to improve our knowledge of diabetes. However, we have not yet reached a comprehensive understanding of the pathophysiology of this complicated disease.In this symposium, the following 4 topics on the hormones that contribute to glucose regulation and diabetes will be covered: incretins, PP cells in the pancreas, glucagon, and FGF21. The speakers will present their cutting-edge research and give updates on the frontiers in their research expertise. By providing updated information on various aspects of the endocrine system and diabetes to the audience, we aim to promote an integrated understanding of these topics and invigorate the research field.
2S06a
Cooperation with Other Societies Committee

Evolving imaging technologies: novel probes and their applications in physiology

Date：Mar 15　14:20 - 16:20　Place：Room 6
Co-hosted by：The Biophysical Society of Japan
Organizer：
Norio Fukuda（Department of Cell Physiology, The Jikei University School of Medicine）
Madoka Suzuki（Institute for Protein Research, Osaka University）
Tetsuya Kitaguchi（Institute of Innovative Research, Tokyo Institute of Technology）
Mako Kamiya（School of Life Science and Technology, Tokyo Institute of Technology）
Kazunori Kanemaru（Nihon University School of Medicine）
Yuko Mimori-Kiyosue（RIKEN Center for Biosystems Dynamics Research）
Madoka Suzuki（Institute for Protein Research, Osaka University）
Imaging technologies are evolving in the biosciences. In this symposium, the cutting-edge progress in the development and applications of novel luminescent / Raman probes will be discussed. We will invite five speakers who have accomplished distinguished achievements in the bio-imaging field. They will present the principles of imaging with the probes and their applications in biosciences. It is expected that the imaging technologies that have been developed in biophysics will be widely applied to various fields of physiology.
2AS07a

Multimodal approach for age-related decline in biological function and anti-aging

Date：Mar 15　14:20 - 16:20　Place：Room 7
Co-hosted by：The Japan Society for Biomedical Gerontology
Organizer：
Sho Kakizawa（Kyoto University）
Sae Uchida（Tokyo Metropolitan Institute of Gerontology）
Shuichi Machida（Juntendo University）
Ayami Sato（Tokyo Metropolitan Institute of Gerontology）
Akiko Satoh（National Center for Geriatrics and Gerontology）
Sae Uchida（Tokyo Metropolitan Institute of Gerontology）
Sho Kakizawa（Kyoto University）
Age-dependent decline in biological functions, aging, is universal phenomenon seen in all organisms. Although many studies demonstrate that aging is affected by various factors related to lifestyle, mechanisms of actions and reciprocal interactions of these factors have not been fully understood. In this symposium, five researchers (including three females) introduce their current topics on effects of olfaction, exercise, sleep, redox metabolites and anti-oxidants on aging. Because our symposium is focused on multimodal approach to aging and anti-aging and interest in extension of healthy life expectancy is increasing, the symposium fits well with the theme of the annual meeting, homeostasis and sustainability, and gives useful insights to many participants.
2S08a

Hyperadaptability for overcoming body-brain dysfunction.

Date：Mar 15　14:20 - 16:20　Place：Room 8
Co-hosted by：Hyper-adaptability
Organizer：
Kazuhiko SEKI（National Center of Neurology and Psychiatry）
Francisco Valero-Cuevas（University of Southern California）
Roland Philipp（National Center of Neurology and Psychiatry）
Hironobu Osaki（Doshisha University）
Osu Rieko（Waseda Univ.）
Jun Izawa（University of Tsukuba）
We are constantly making predictions. However, these predictions are not always correct, and most of the time they are not in line with reality, to a greater or lesser degree. Therefore, our lives are full of surprises (sensory prediction error). Our nervous system adapts to these errors, but there are times (e.g., congenital malformations, diseases, accidents, etc.) when the errors are too large to be accommodated by normal adaptation. We believe that the central nervous system maintains physiological functions by inducing “hyper-adaptation” at such times. In this symposium, we will introduce an approach to elucidate the operating principles and functional significance of this hyper-adaptability through an interdisciplinary approach including engineering, medicine, and biology.
2S09a

The frontier of gastrointestinal and vascular pathophysiology research associated with the intestinal environment

Date：Mar 15　14:20 - 16:20　Place：Room 9
Organizer：
Lin Kurahara（Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University）
Eikichi Ihara（Department of Gastroenterology and Metabolism, Graduate School of Medical Sciences, Kyushu University）
Kazuhiro Nishiyama（Department of Physiology, Graduate School of Pharmaceutical Sciences Kyushu University）
Takahiko Shiina（Laboratory of Veterinary Physiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University）
Yoko Igarashi（Research Center, Mochida Pharmaceutical Co., Ltd.; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University）
Keizo Hiraishi （Department of physiology, Faculty of Medicine, Fukuoka University）
Masashi Mukohda（Laboratory of Veterinary Pharmacology, Faculty of Veterinary Medicine, Okayama University of Science）
Disrupted immune response is commonly involved in the gut pathophysiology such as inflammatory bowel disease (IBD) and non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy. Many of them have no fundamental therapy yet because of incomplete elucidation of their pathogenesis. In this symposium, we attempt to cover the latest findings about the molecules participating in gastrointestinal pathophysiology with the analyses on neuromuscular transmission, intestinal flora, epithelial barrier function, and microbiome-mediated vascular homeostasis. Recapitulating what is being known about the pathophysiology of gastrointestinal disorders and the multi-organ relationships in the intestinal environment from macro and micro perspectives.
2S01e
Committee for Promotion of Physiome and Systems Biology

Brain Computer Interface: Neurophysiological Perspectives

Date：Mar 15　16:30 - 18:30　Place：Room 1
Organizer：
Yoshihisa Kurachi（Osaka University）
Tetsuya Yagi（Fukui University of Technology）
Hiroshi Hibino（Osaka University）
Tetsuya Yagi（Fukui University of Technology）
Yoshihiro Tanaka（Nagoya Institute of Technology）
Takufumi Yanagisawa（Osaka University, Institute for advanced co-creation studies）

BCI(Brain Computer Interface) is an medicine and information technology in future that links
the brain and computer using advanced electronics devices. Recently, a famous　venture company embarked on the development of BCI, which have drawn world-wide attentions. Moreover, recent development of artificial intelligent further provoked ideas of BCI technology to be applied not only in the medical practice but also in the future human communications. However, the current situation of BCI technology is often overestimated despite that many of the proposed BCI applications are still on an early stage of research. On these backgrounds, this symposium overviews the current status of BCIs covering the artificial cochlea as the first successful medical device and BCI systems implemented with virtual reality (VR) and AI technologies, delving into the feasibility and problems of BCI with regard to clinical translation from the neurophysiological point of view.

2AS02e

pH and life on earth ; transient and persistent chronology of life adaptation and environments

Date：Mar 15　16:30 - 18:30　Place：Room 2
Organizer：
Yasushi Okamura（Osaka University）
Nobuaki Takahashi（Kyoto University）
Nobuaki Takahashi（Kyoto University）
Haruko Kurihara（University of the Ryukyus）
Yoshimi Kubota（National Museum of Nature and Science）
Yosuke Funato（Osaka University）
Masayuki Oginuma （Osaka University）
During 4.6-billion-year history of Earth, the ocean pH has intensely fluctuated. The primitive atmosphere mainly constituted of CO2, which drove the emergence of life, and thereafter, CO2 and ocean pH levels were gradually neutralized with great fluctuations, which imposed “selective pressure” for life to adapt to environmental pH changes. Interestingly, these adaptation systems are not only preserved in human bodies but also utilized to drive various physiological responses. In this symposium, young innovative scientists in the field of physiology, chemistry, paleontology, and marine biology will introduce their cutting-edge of science and discuss future direction of the impact of global environmental changes including ocean acidification on life.
2S03e

Dynamic neural mechanisms for adaptation to uncertain external environments: Next-generation physiological research

Date：Mar 15　16:30 - 18:30　Place：Room 3
Organizer：
Masaaki Ogawa（Kyoto University）
Kosuke Hamaguchi（Kyoto University）
Rie Kimura（The University of Tokyo）
Kosuke Hamaguchi（Kyoto University）
Katsuhiko Miyazaki（Okinawa Institute of Science and Technology）
Daisuke Miyamoto（University of Toyama）
Masaaki Ogawa（Kyoto University）
Confronted with uncertain external environments, animals can estimate the state of the environment from past experiences to adapt actively and flexibly. By integrating recent advances in neural recording and manipulation techniques with refined behavioral tasks and computational approaches, a new era has arrived in which physiological mechanisms underlying various adaptive behaviors can be studied at an unprecedented level of specificity, providing new opportunities for original and creative research. This symposium will present the latest research that reveals the dynamic neural mechanisms that control motivation, perseverance, memory, and behavioral strategies necessary to adapt to uncertain external environments through such next-generation physiological research.
2S05e

Understanding chronic inflammatory diseases from a metabolic perspective

Date：Mar 15　16:30 - 18:30　Place：Room 5
Organizer：
Ayaka Ito（Department of Molecular Medicine and Metabolism, Research Institute of Environmental MedicineInstitute for Advanced Research, Nagoya University）
Satoko Arai（Laboratory of Molecular Biomedicine for Pathogenesis Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo）
Yosuke Kurashima（Innovative Medicine, Graduate School of Medicine and School of Medicine, Chiba University）
Satoko Arai（Laboratory of Molecular Biomedicine for Pathogenesis Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo ）
Michiko Itoh（Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityKanagawa Institute of Industrial Science and Technology）
Yoshikazu Johmura（Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University）
Ayaka Ito（Department of Molecular Medicine and Metabolism, Research Institute of Environmental MedicineInstitute for Advanced Research, Nagoya University）
It has been uncovered that chronic inflammation involves in the formation and progression of various diseases, including autoimmune diseases, metabolic diseases such as obesity and atherosclerosis, neurodegenerative diseases such as Alzheimer’s disease, and cancer. Overnutrition causes inflammatory responses during metabolic diseases. On the contrary, in response to activation signals, immune cells cause metabolic reprogramming to meet the energetic demands. Therefore, deeper research into the crosstalk between metabolism and immune responses is required to better understand pathology of chronic inflammatory diseases. This symposium will highlight the latest research on the pathogenesis and progression of chronic inflammatory diseases from a perspective of metabolic-immune crosstalk.
2S06e

Regulatory mechanisms of voltage-gated cation channels and their significance in maintaining homeostasis

Date：Mar 15　16:30 - 18:30　Place：Room 6
Organizer：
Takashi Murayama（Department of Pharmacology, Juntendo University School of Medicine）
Satomi Adachi-Akahane（Department of Physiology, Faculty of Medicine, Toho University）
Koichi Nakajo（Division of Integrative Physiology, Department of Physiology, Jichi Medical University）
Satomi Adachi-Akahane（Department of Physiology, Faculty of Medicine, Toho University）
Tomoya Kubota（Clinical Neurophysiology, Department of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, Osaka University Graduate School of Medicine）
Mitsuhiko Yamada（Department of Molecular Pharmacology, Shinshu University School of Medicine）
Hiroyuki Nakamura（Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine）
Voltage-gated cation channels (VGCCs) play a central role in signal transduction using electrical signals and are involved in maintaining various homeostatic mechanisms such as sensory, secretory, and renal functions as well as nerve transmission and muscle contraction. In this symposium, five speakers will give talks on the regulatory mechanisms of VGCCs and their significance in maintaining homeostasis: regulatory mechanisms of the voltage-gated K+ channel (Nakajo) and the L-type Ca2+ channel (LTCC) (Adachi-Akahane), involvement of LTCC in heartbeat formation (Yamada), disease-causing mutations in the voltage sensor domain (Kubota), and Nav1.7 mutations causing analgesia (Nakamura). We hope that this symposium will spark the interest of PSJ members in studying VGCCs and lead to the development of future collaborations.
2S07e

Circadian rhythms serve as platform for homeostasis and sustainability of life: Toward overcoming health problems by the clock disfunction

Date：Mar 15　16:30 - 18:30　Place：Room 7
Organizer：
Masaaki Ikeda（Department of Physiology, Faculty of Medicine, Saitama Medical University）
Teruya Tamaru（Department of Physiology, Toho University School of Medicine）
Masaaki Ikeda（Department of Physiology, Faculty of Medicine, Saitama Medical University）
Teruya Tamaru（Department of Physiology, Toho University School of Medicine）
Hitomi Kaneko（Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University）
Atsushi Haraguchi（Waseda University, School of Advanced Science and Engineering, Laboratory of physiology and pharmacology）
HIkari Yoshitane（Circadian Clock Project, Tokyo Metropolitan Institute of Medical Science）
Circadian clocks in the whole body are cell-based molecular clocks cycling autonomously, sustainably with clock genes (Bmal1, Clock etc.) -mediated molecular processes. Clocks govern genome-wide daily gene expression to serve as platforms for homeostasis and sustainability of physiological functions and health. Shift work, global network, super-aging, pandemic, isolate human clocks from environment to generate time differences between intrinsic rhythms and rhythms forced by society, weaken adaptability, thereby invite slumps such as sleep disorder, weakening immunity, finally various diseases (cancer, lifestyle-related diseases, mental illness). We develop discussion toward overcoming health problems related to clock sustainability through latest topics concerning clock synchronization, endocrine, iPS cells, Kampo, and aging.
2S08e

Environmental Adaptation of Skeletal Muscles and Adipose Tissues

Date：Mar 15　16:30 - 18:30　Place：Room 8
Organizer：
Takahiro Nemoto（Dept. Physiology, Nippon Medical School）
Takahumi Gotoh（Dept. Agricultural Science and Natural Resources, Kagoshima University）
Takahiro Nemoto（Dept. Physiology, Nippon Medical School）
Shinji Miura（Laboratpry of Nutritional Biochemistry, School of Food and Nutritional Science, University of Shizuoka）
Satoru Ikenoue（Department of Obstetrics and Gynecology, Keio University School of Mediciene）
Shinobu Yasuo（Faculty of Agriculture, Kyushu University）
Takahumi Gotoh（Dept. Agricultural Science and Natural Resources, Kagoshima University）
The DOHaD theory is thought to be the risk of developing a disease is formed by the mismatch between the constitution acquired during the embryonic period and the environment after birth. A poor nutritional environment at the developmental stage transforms the phenotype of the fetus into a thrifty phenotype that consumes less energy. A mismatch between the thrifty phenotype and environment is a factor that forms the risk of a disease in humans but is expected to be applied as an inducer of crossbreeding in the field of livestock. Therefore, in this symposium, we would like to discuss how the properties of fat and skeletal muscle are formed from the viewpoint of the mechanism of the thrifty phenotype formation, and the availability of sustainable applications that can be developed.
2S09e

Hot topics on nuclear envelope

Date：Mar 15　16:30 - 18:30　Place：Room 9
Organizer：
Yukiko Hayashi（Tokyo Medical University）
Kazunori Imaizumi（Hiroshima University）

Yukiko Hayashi（Tokyo Medical University）
Yuta Shimamoto（National Institute of Genetics）
Yasunao Kamikawa（Hiroshima University）
Takeshi Shimi（Institute of Innovative Research, Tokyo Institute of Technology）
Eiji Wada（Tokyo Medical University）

The nuclear envelope (NE) is a biological membrane that separates the nucleoplasm of eukaryotes from the cytoplasm. NE has a double membrane structure of the inner and outer membranes. The nuclear lamina underlies inner nuclear membrane and linked to chromatin. Material transport between the nucleus and cytoplasm is carried out by a giant protein complex called the nuclear pore complex. NE changes dynamically during cell cycle and has important roles in gene regulation. Mutations in the genes encoding NE proteins cause various diseases such as muscular dystrophy, cardiomyopathy, and progeria. In this symposium, recent exciting advances on NE research such as NE responses on mechanical stress, damage responses of NE, and pathophysiology of nuclear envelopathy will be discussed.
3AS01m

Understanding "Pre-Diseases" (Mibyo): Challenges from Cutting-Edge Mathematical Sciences

Date：Mar 16　9:00 - 11:00　Place：Room 1
Co-hosted by：Japan Science and Technology Agency（JST）Moonshot Goal2
Organizer：
Kazuyuki Aihara（The University of Tokyo）
Shingo Iwami（Nagoya University）
Shingo Iwami（Nagoya University）
Keiichi Koizumi（University of Toyama）
Yukinori Okada（Osaka University）
Katsuhito Fujiu（The University of Tokyo）
The MOONSHOT R&D Program at JST aims to “Realization of ultra-early disease prediction and intervention by 2050” as the Moonshot Goal 2. Under this framework, both mathematical research as well as experimental & clinical research focusing on cancer, diabetes, neurological disorders, and viral infections are being conducted at present. In particular, major difference from conventional studies of diseases is the definition and detection of “pre-disease” (Mibyo) states, which have not yet developed into illnesses but are approaching the timing leaving the normal state of health. Further, precision medicine at a very early stage is targeted by detection of Mibyo. In this symposium, we would like to introduce examples of applications to specific diseases analysed by mathematical methods and discuss the future direction of such research.
3AS02m

Generational interaction in the study on thermo-sensitive Transient Receptor Potential (TRP) channel

Date：Mar 16　9:00 - 11:00　Place：Room 2
Organizer：
Yasunori Takayama（Department of Physiology, Showa University School of Medicine）
Makoto Tominaga（Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS)）
Makoto Tominaga（Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS)）
Makiko Kashio（Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS)）
Ryuta Koyama（Laboratory of Chemical Pharmacology,Graduate School of Pharmaceutical Sciences,The University of Tokyo）
Hisashi Shirakawa（Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University）
TRP channel, firstly reported in Science by Dr. Craig Montell in 1985, has grown into a huge research field. Especially, the principal reports on TRP vanilloid 1 (TRPV1) by Dr. David Julius and his colleagues in 1997 and 1998 are the milestones to identify the physiological and pathological significances of TRP channels. It is already known well that TRP channels including capsaicin receptor TRPV1 are “sensor” proteins activated by natural stimuli such as temperature changes, mechanical stress, and natural compounds. Here, we focus on thermo-sensitive TRP channels that play some roles in critical temperature zones including brain temperature, and present the advanced studies by fascinating scientists. Through this symposium, we hope the novel conceptions of thermo-sensitive TRPs for future.
3S03m

Elucidation of the molecular and neural basis of sleep quality and its physiological action

Date：Mar 16　9:00 - 11:00　Place：Room 3
Organizer：
Yu Hayashi（Department of Biological Sciences, Graduate School of Science, University of Tokyo）
Michihiro Mieda（Kanazawa University）
Shinnosuke Yasugaki（University of Tsukuba）
Hiromasa Funato（Toho University）
Tomomi Tsunematsu（Tohoku University）
Kaoru Inokuchi（University of Toyama）
Mieda Michihiro（Kanazawa University）
In recent years, the elucidation of neural circuits responsible for switching between sleep and wake states have largely advanced. By contrast, the function of sleep remains unclear. In this symposium, we define “good sleep” as sleep that is beneficial for improving the function of individuals. We invite researchers who focus on the effects of sleep on memory learning, stress, brain homeostasis, circadian rhythm, brain oscillatory activity, and protein modification. This symposium will address the entity of good sleep that contributes to “homeostasis and sustainability,” the theme of this conference. From the viewpoint of diversity promotion, two young researchers and one female researcher will be included as speakers.
3AS04m

Next-generation technologies for the functional analysis of life at the organism level

Date：Mar 16　9:00 - 11:00　Place：Room 4
Organizer：
Kyoji Horie（Nara Medical University）
Kenta Sumiyama（Nagoya University）
Masato Ohtsuka（School of Medicine, Tokai University）
Keiichiro Suzuki（Osaka University Institute for Advanced Co-Creation Studies）
Shinya Oki（Graduate School of Medicine, Kyoto University）
Etsuo Susaki（Juntendo University Graduate School of Medicine）
Michiyuki Matsuda（Graduate School of Biostudies, Kyoto University）
In recent years, technological innovations have been made to elucidate life phenomena at the organism level. The progress of genome editing technologies such as CRISPR-Cas has dramatically increased the speed at which genetically modified organisms are produced. Genetic modification at the somatic cell level is advancing, and its application to gene therapy is becoming a reality. The development of various fluorescent biosensors has also progressed, allowing real-time quantitative analysis of life phenomena in various cell lineages. The advancement of spatial transcriptome and tissue clearing technology has introduced a new dimension of spatial information. In this symposium, we will invite researchers at the forefront of developing such novel technologies and discuss the applicability of these technologies to life science in the future.
3S06m
International Relations Committee

Adaptative regulation of muscle contraction in health and disease

Date：Mar 16　9:00 - 11:00　Place：Room 6
Co-hosted by：IUPS(YoP)-PSJ Joint Symposium
Organizer：
Yuji Hara（University of Shizuoka, School of Pharmaceutical Sciences, Department of Integrative Physiology）
Susan Wray（University of Liverpool, Department of Cellular and Molecular Physiology）
Yuji Hara（University of Shizuoka, School of Pharmaceutical Sciences, Department of Integrative Physiology）
Toshiko Yamazawa（The Jikei University School of Medicine, Department of Molecular Physiology, ）
Robyn Murphy（La Trobe University School of Agriculture）
Susan Wray（University of Liverpool, Department of Cellular and Molecular Physiology）
3S07m
Cooperation with Other Societies Committee

Frontiers of structure-function relationship analysis: Visualization of dynamic structural features underlying life phenomena

Date：Mar 16　9:00 - 11:00　Place：Room 7
Co-hosted by：The Japanese Association of Anatomists
Organizer：
Hiroyuki Hioki（Department of Neuroanatomy, Juntendo University Graduate School of Medicine）
Tomomi Nemoto（National Institute for Physiological Sciences）
Keisuke Miyazawa（Faculty of Frontier Engineering, Institute of Science and Engineering, Kanazawa University）
Yusuke Hirabayashi（School of Engineering, The University of Tokyo）
Yutaro Kashiwagi（Department of Cellular Neuroscience, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo）
Kohei Otomo（Dept Biochem Systems Biomed, Grad Sch Med, Juntendo Univ/Biophotonics Res Group, Exploratory Res Cent on Life and Living Systems/Dept Biophotonics, Natural Inst Physiol Sci, Natl Inst Natural Sci）
Physiological functions are created over a wide range of spatial scales, including such as molecules, organelles, cells, tissues, and organs, and a seamless understanding of the mechanisms by which functions are created over these different scales is necessary to further deepen our understanding of biological phenomena. Therefore, the development of visualization techniques that enable observation of various spatial resolutions and areas of interest (regions) is rapidly advancing. In this symposium, young leading researchers will introduce their latest visualization techniques and obtained results. By sharing the state-of-the-art visualization techniques and their future prospects, we hope that this symposium will help participants to broaden their research options.
3S08m

New insights into central dopaminergic system

Date：Mar 16　9:00 - 11:00　Place：Room 8
Organizer：
Toshihiko Momiyama（Department of Pharmacology, Jikei University School of Medicine ）
Masayuki Masu（Faculty of Medicine, University of Tsukuba）
Akinori Nishi（Department of Pharmacology, Kurume University School of Medicine）
Takatoshi Hikida（Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University）
Masayuki Masu（Faculty of Medicine, University of Tsukuba）
Kazuto Kobayashi（Fukushima Medical University ）
Etsuko Suzuki（Department of Pharmacology, Jikei University School of Medicine ）
The corresponding organizer attended the symposium of this meeting entitled “Dopamine-mediated regulation of brain network and plasticity” as a speaker in Morioka, 2010, and organized another symposium of this meeting entitled “Neuronal circuit in the basal ganglia in terms of transmitters and receptors” in Kobe, 2015. These symposiums were mainly focused on neuronal circuits, transmitters and receptors in the central dopaminergic system and/or basal ganglia. The present application for the symposium aims to elucidate unknown functions of the central dopaminergic system, focusing on the modulators or parameters that have not so far been analyzed in relation to the system. The symposium is expected to provide new insights into the physiological functions, as well as the disorders of the system.
3S09m

Dynamic correlation between subcellular structures and functions for neuronal signaling

Date：Mar 16　9:00 - 11:00　Place：Room 9
Organizer：
Takafumi Miki（Graduate School of Brain Science, Doshisha University）
Haruyuki Kamiya（Department of Neurobiology, Graduate School of Medicine, Hokkaido University）
Haruyuki Kamiya（Department of Neurobiology, Graduate School of Medicine, Hokkaido University）
Takafumi Miki（Graduate School of Brain Science, Doshisha University）
Alain Marty（Saints-Peres Paris Institute for the Neurosciences, CNRS, Universite de Paris）
Cordelia Imig（Department of Neuroscience, University of Copenhagen）
Shin-ya Kawaguchi（Department of Biophysics, Graduate School of Science, Kyoto University）
Higher brain functions in animals rely on neuronal communication. Recent technical advances, such as direct patch-clamp recordings and fluorescence molecular imaging in neuronal compartments, and electron microscopic observations of intracellular nano-structures with the flash & freeze method, are shedding light on the nano-to-micro scale and millisecond dynamics of subcellular neuronal structures and functions. In this symposium, we introduce cutting-edge researches that examine the dynamic correlation between the structures and functions for neuronal signaling in axons, synapses, and dendrites at the high-resolution level. The aim of the symposium is to provide an updated view on molecular mechanisms underlying the fine-tuned signaling in the brain.
3S10m

Circadian rhythms of intra- and extra-ocular physiological functions

Date：Mar 16　9:00 - 11:00　Place：Room 10
Organizer：
Keisuke Ikegami（Department of Physiology, School of Medicine, Aichi Medical University）
Yoshiki Tsuchiya（Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine）
Keisuke Ikegami（Depertment of Physiology, School of Medicine, Aichi Medical University）
Ethan Buhr（Department of Ophthalmology, University of Washington）
Yoshiki Tsuchiya（Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine）
Masao Doi（Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University）
Human obtains a lot of perceptual information from vision. Therefore, age- and lifestyle-related decline in physiological functions of the eye would lower the quality of life. Additionally, the eye not only receives visual information but also transmits light/dark information to reset the circadian clock, and the circadian time signals are received by the eye itself to regulate its own rhythms. Although these regulations are not fully understood, recent findings have made great progress on circadian rhythm research for the eye. In this symposium, we welcome the speakers who investigate the ocular circadian physiological functions to deepen the integrated understanding of intra- and extra-ocular physiology by discussing the latest research on circadian rhythms of the eyelids, cornea, retina, and intraocular pressure.
3S03a
International Relations Committee

Prenatal and perinatal physiology - Adaptation to drastic environmental change

Date：Mar 16　14:20 - 16:20　Place：Room 3
Co-hosted by：IUPS(YoP)-PSJ Joint Symposium
Organizer：
Utako Yokoyama（Tokyo Med University）
Laura Bennet（University of Auckland, New Zealand）
Laura Bennet（University of Auckland, New Zealand）
Chia-Wen Lin（Kobe Univesrsity & RIKEN）
Utako Yokoyama（Tokyo Med University）
Janna Morrison（University of South Australia, Adelaide, Australia）
3S04a

Elucidation of brain information decoded by glia

Date：Mar 16　14:20 - 16:20　Place：Room 4
Organizer：
Hiroaki Wake（Nagoya University Graduate School of Medicine）
Schuichi Koizumi（Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi）
Hiroaki Wake（Nagoya University Graduate School of Medicine）
Shigeo Okabe（Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo）
Misa Arizono （Department of Pharmacology Kyoto University, Graduate school of Medicine）
Schuichi Koizumi（Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi）
The central nervous system contains neurons and glial cells, and the high proportion of glial cells in higher animals suggests their involvement in higher brain functions. Recently, glial cells have been suggested to be strongly involved in brain diseases and have attracted attention as a target for drug discovery. In this symposium, we would like to introduce the frontiers of glial research by having four researchers who are conducting research to clarify the functions of glial cells and how they decode brain information based on multifaceted analysis.
3S05a
Science and Research Committee / The Japanese Medical Science Federation Member society Collaborative Forum

Inter-organ communication underlying homeostasis and sustainability: mechanisms of its regulation and failure

Date：Mar 16　14:20 - 16:20　Place：Room 5
Co-hosted by: The Japanese Biochemical Society / Japan Society of Neurovegetative Research
Organizer：
Kazuhiro Nakamura（Dept. Integr. Physiol., Grad. Sch. Med., Nagoya Univ. ）
Fusao Kato（Dept. Neurosci., Jikei Univ. Sch. Med. ）
Kazuhiro Nakamura（Dept. Integr. Physiol., Grad. Sch. Med., Nagoya Univ. ）
Ayuko Hoshino（Sch. Life Sci. Tech., Dept. Life Sci. Tech., Tokyo Inst. Tech. ）
Yohei Mikami（Div. Gastroenterol. & Hepatol., Dept. Internal Med., Keio Univ. Sch. Med.）
Junta Imai（Dept. Int. Med., Grad. Sch. Med., Tohoku Univ.）
Ryosuke Takahashi（Dept. Neurol., Grad. Sch. Med., Kyoto Univ.）
This symposium aims to overlook and discuss the regulatory mechanisms of inter-organ communication underlying homeostasis and sustainability of the human body via extracellular secretory vesicles, neural networks, immune networks, etc., by bringing leading researchers in basic and clinical medicine together. We will further introduce cutting-edge research on the role of inter-organ communication in the pathogenesis of disease and its therapeutic application.
3S06a

Mechanisms of hippocampal function revealed by in vivo large-scale recording

Date：Mar 16　14:20 - 16:20　Place：Room 6
Organizer：
Kenji Mizuseki（Osaka Metropolitan University）
Hiroyuki Miyawaki（Osaka Metropolitan University）
Susumu Takahashi（Graduate School of Brain Science, Doshisha University）
Kazumasa Tanaka（Okinawa Institute of Science and Technology (OIST), Memory Research Unit）
Teruhiro Okuyama（The University of Tokyo, Institute for Quantitative Biosciences (IQB)）
Hiroyuki Miyawaki（Osaka Metropolitan University）
Recently, many researchers in Japan have used physiological measurements on freely behaving animals to analyze hippocampal function. Recently, there has been an increase in ambitious research to measure brain activity not only from mice and rats in the laboratory but also from birds and fish that are freely moving in nature. In addition, research to describe the relationship between neural activity and behavior more rigorously is progressing through the fusion of optogenetics and large-scale physiology, large-scale recordings from animals engaged in social behavior, and large-scale simultaneous measurements from multiple brain regions. This symposium aims to introduce the latest research by up-and-coming young researchers conducting the studies as mentioned above.
3S07a

Molecular and neural circuit mechanisms of eating behavior and metabolic process

Date：Mar 16　14:20 - 16:20　Place：Room 7
Organizer：
Nobuyuki Sakayori（Department of Physiology and Oral Physiology, Graduate School of Biomedical and Health Sciences, Hiroshima University）
Takaaki Ozawa（Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University）
Takaaki Ozawa（Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University）
Yuki Narimatsu（Graduate school of integrated sciences for life, Hiroshima University）
Ikue Kusumoto-Yoshida（Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University）
Nobuyuki Sakayori（Department of Physiology and Oral Physiology, Graduate School of Biomedical and Health Sciences, Hiroshima University）
To prevent and treat lifestyle diseases, deeper understanding of molecular and neural circuit mechanisms underlying adaptive eating and food choice behavior is important. In this symposium, young researchers in various research fields introduce their recent findings about the regulatory mechanism of eating behavior focusing on 1) the synergism between different tastes and the role of dopamine (Takaaki Ozawa), 2) the hypothalamic projection to insular cortex (Ikue Kusumoto-Yoshida), 3) a novel hypothalamic releasing factor regulating lipid metabolism (Yuki Narimatsu), and 4) nutritional impacts on dopaminergic system (Nobuyuki Sakayori). We believe our symposium has wide-reaching implications to solve an ongoing global health crisis by promoting interdisciplinary basic studies.
3S08a

The basal ganglia -beyond motor control functions-

Date：Mar 16　14:20 - 16:20　Place：Room 8
Organizer：
Yoshihisa Tachibana（Kobe University Graduate School of Medicine）
Atsushi Nambu（National Institute for Physiological Sciences）
Thomas Boraud（Universite de Bordeaux）
Taku Hasegawa（RIKEN）
Yoshihisa Tachibana（Kobe University Graduate School of Medicine）
Ayano Matsushima（McGovern Institute for Brain Research）
The basal ganglia are composed of the striatum, globus pallidus, subthalamic nucleus, and substantia nigra. Their motor control function has long been proposed because degeneration of dopaminergic neurons in the substantia nigra causes motor symptoms in Parkinson’s disease, supported by electrophysiological recordings, pharmacological interventions, and electrical stimulation methods. Their new functions have been recently revealed through the newly developed tools such as viral tracing, molecular biological tools including RNAseq, calcium imaging, and optogenetic/chemogenetic manipulations, and human brain imaging. In this symposium, we will focus on new functions of the basal ganglia, such as emotional and cognitive functions in addition to motor control and discuss the future direction of the basal ganglia research.
3S09a

Divergent roles of mitochondria: regulation of excitability, cell death/survival, metabolism and beyond

Date：Mar 16　14:20 - 16:20　Place：Room 9
Organizer：
Tomoe Nakamura-Nishitani（Department of Pharmacology, School of Medicine, Wakayama Medical University）
Ayako Takeuchi（Department of Integrative and Systems Physiology, Faculty of Medical Sciences, University of Fukui）
Takaya Ishihara（Department of Biological Sciences, Graduate School of Science, Osaka University）
Akiyuki Nishimura（National Institute for Physiological Sciences）
Ayako Takeuchi（Department of Integrative and Systems Physiology, Faculty of Medical Sciences, University of Fukui）
Tomoe Nakamura-Nishitani（Department of Pharmacology, School of Medicine, Wakayama Medical University）
Norihito Shintani（Laboratory of Pharmacology, School of Pharmaceutical Sciences, Wakayama Medical University）
Mitochondria have various functions such as energy metabolism, cell death/survival and Ca2+ signal regulations. However, precise mechanisms underlying the diversity are still unclear. In this symposium, we will focus on the various factors that regulate mitochondrial morphology/functions to unravel this mystery. Specifically, we will introduce the roles of mitochondria dynamics-related molecules, reactive sulfur species, and mitochondrial protein p13 in the mitochondrial structure/functions and quality control. In addition, Ca2+-dependent regulation of mitochondrial biosynthesis, and tissue-specific regulation of mitochondrial Ca2+ signals will be discussed. Through these, we will summarize the physiological/pathological significance of mitochondria, and its potential for maintaining homeostasis against various stresses.
3S10a
Cooperation with Other Societies Committee

Physiological research as a basis for rehabilitation (physical therapy)

Date：Mar 16　14:20 - 16:20　Place：Room 10
Co-hosted by：Japanese Society of Physical Therapy
Organizer：
Hidehiko Komine（Human-Centered Mobility Research Center, National Institute of Advanced Industrial Science and Technology）
Susumu Urakawa（Department of Musculoskeletal Functional Research and Regeneration, Graduate School of Biomedical and Health Sciences, Hiroshima University）
Naoki Tajiri（Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences）
Erika Iwamoto（School of Health Sciences, Sapporo Medical University）
Dai Mitsushima（Department of Physiology, Yamaguchi University Graduate School of Medicine）
Kazue Mizumura（Department of Physiology, Nihon University School of Dentistry）
Rehabilitation (physical therapy) targets a wide range of fields, including stroke and other central nervous system diseases, orthopedic diseases, and cardiovascular diseases. In all of these fields, a clinical approach based on physiological functions is important. In order to improve or develop clinical approaches, it is necessary to conduct physiological research to verify clinical hypotheses or, conversely, to construct clinical hypotheses based on new research results and findings in physiology. In this symposium, four speakers will present and discuss their research on neuroprotection, prevention of artery stiffness, neural mechanisms of motor learning, and mechanisms of pain as the basis of physiological research for rehabilitation (physical therapy).
3AS01e

Innovative Brain Research - Toward a comprehensive understanding of the neural circuits underlying higher brain functions

Date：Mar 16　16:30 - 18:30　Place：Room 1
Supported by：AMED
Organizer：
Shigeo Okabe（Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo）
Masanori Murayama（Lab for Haptic Perception and Cognitive Physiology, RIKEN Center for Brain Science）
Shinsuke Koike（Department of Arts and Sciences, The University of Tokyo）
Akiya Watakabe（RIKEN Center for Brain Science）
Masanori Murayama（RIKEN Center for Brain Science）
Tomomi Shimogori（RIKEN Center for Brain Science）
Ken Nakae（Kyoto University）
A large-scale national brain project was launched in 2014 to understand the overall structure and mechanisms of the brain comprehensively. The project, called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS), specifically aims to elucidate the neural circuits underlying higher brain functions using unique experimental methods and animal models. This joint symposium invites young researchers with notable contributions to Brain/MINDS. We want to discuss and share with participants the necessary technologies, resources, and research measures to advance innovative brain research further. Toward this goal, Brain/MINDS provides open resources for cutting-edge technologies and databases, which will help build a collaborative network connecting scientists in diverse research fields.
3S02e
Cooperation with Other Societies Committee

State-of-the-art in stress research

Date：Mar 16　16:30 - 18:30　Place：Room 2
Co-hosted by：Japan Neuroendocrine Society
Organizer：
Tatsushi Onaka（Jichi Medical University）
Mayumi Nishi（Nara Medical University）
Masahide Yoshida（Jichi Medical Unuversity）
Horii Noriko（Nara Medical University）
Naoya Kataoka（Nagoya University）
Fuko Matsuda（The University of Tokyo）
Reiko Kobayakawa（Kansai Medical University）
Living organisms maintain homeostasis in a variety of environments by inducing adaptive responses towards aversive stimuli. In a stressful condition, there is a threat of homeostasis being disrupted. Although the definition of stress is ambiguous and controversial, epidemiological studies have shown that stress affects life expectancy. Recent developments of molecular techniques have made it possible to investigate detailed mechanisms underlying physiological or pathological responses at levels of molecules, cells, neural circuits, organs, and whole bodies. As a result, molecular mechanisms of stress responses are becoming clear in various stress models. We would like to discuss concerning forefronts of stress research including the general concept of stress.
3S03e
Committee for Editorial Board of the Journal of Physiological Sciences

Discuss how to publish our physiology research

Date：Mar 16　16:30 - 18:30　Place：Room 3
Organizer：
Makoto Tominaga（National Institute for Physiological Sciences）
Motohiko Sato（Aichi Medical University）
Motohiko Sato（Aichi Medical University）
Sharona Gordon（University of Washington）
Lesley Anson（collaborating with eLife to launch the field-specific CoLabs）
I would like to discuss how to prepare a good physiology paper with people working as editors in the high international journals. Dr.Gordon is a ex-chief editor of Journal of General Physiology, and Dr. Anson is a founding editor of Nature Communications and now collaborating with eLife to launch the field-specific CoLabs, a new publishing platform.
3AS04e
Committee for 100th anniversary / Education Committee

Physiology Education - present, past, and future-

Date：Mar 16　16:30 - 18:30　Place：Room 4
Organizer：
Michio Shiibashi（Saitama Medical University）
Fumihito ONO
Noriyuki Koibuchi（Gunma University Graduate School of Medicine, Integrative Physiology）
Okamura Yasushi（Osaka University Graduate School of Medicine & Fronteir Biosciences, Integrative Physiology）
Noriko Osumi（Tohoku University Graduate School of Medicine, Developmental Neuroscience）
Susumu Minamisawa（The Jikei University School of Medicine）
Physiology has the characteristics of a discipline with an integrative perspective, such as multi-organ relationships and individual functions, and it is important for the future of physiology education to make the most of these characteristics. From this perspective, we will discuss what physiological societies have contributed to education in the past, what are the characteristics and challenges of current physiology education, what the future of physiology education should be, and how the Japanese Physiological Society should contribute to this education. The symposium will consist of lectures by four speakers followed by a panel discussion.
3S05e

Innovative neuro-chemical biology for understanding neuronal and synaptic functions

Date：Mar 16　16:30 - 18:30　Place：Room 5
Co-hosted by：JST-ERATO HAMACHI Innovative Molecular Technology for Neuroscience
Organizer：
Wataru Kakegawa（Department of Physiology, Keio University School of Medicine）
Shigeki Kiyonaka（Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University）
Hiroshi Nonaka（Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University）
Kazuya Nozawa（Department of Physiology, Keio University School of Medicine）
Mikiko Takato（Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University）
Kiwamu Takemoto（Department of Biochemistry, Mie University, Graduate School of Medicine）
Shigeki Kiyonaka（Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University）
With the development of mouse genetic engineering and genome editing technology in recent years, we have entered an era in which we can talk about higher brain functions such as learning and memory at the molecular level. However, due to the side effects of gene manipulation, there are a lot of controversial results so far. To overcome these problems, an innovative chemical biology technique capable of acutely and reversibly intervening in endogenous proteins in the brain has been developed. In this symposium, we aim to share new findings on the innovative “neuro-chemical biology”, such as proteomics targeting endogenous proteins in the brain, chemical labeling, single-molecule activation technology, and opto/chemogenetics, to understand the molecular mechanisms of the physiological functions in the brain.
3S06e

Mind sensing by an integration of neuroscience and engineering technologies and its use for communication aid

Date：Mar 16　16:30 - 18:30　Place：Room 6
Co-hosted by：Moonshot Goal 9 R&D Project "Development of 'Jizai Hon-yaku-ki (At-will Translator)' connecting various minds based on brain and body functions", Miyuki Giken Co,LTD
Organizer：
Ken-Ichiro Tsutsui（Tohoku University）
Takuya Sasaki（Tohoku University）
Ken-Ichiro Tsutsui（Tohoku University）
Takuya Sasaki（Tohoku University）
Keiichi Kitajo（NIPS）
Maki Sugimoto（Keio University）
Masahiko Inami（University of Tokyo）
This symposium aims to introduce a new research and development project which aims to realize mind sensing and perceptual, motor, and cognitive interventions by integrating neuroscience and engineering technologies. (Moonshot Goal #9, “Development of “At-will Translator” connecting various minds based on brain and body functions”) We aim to showcase the element technologies for mind sensing and perceptual, motor, and cognitive interventions and discuss the future that will be brought by this project.
3S07e

Homeostatic regulation by a cooperation of sensory function and autonomic nervous system

Date：Mar 16　16:30 - 18:30　Place：Room 7
Organizer：
Keisuke Yonehara（Research Organization of Information and Systems, National Institute of Genetics）
Takako Ichiki（Niigata University, Graduate School of Medical and Dental Sciences）
Chikara Abe（Gifu University, Graduate School of Medicine）
Takako Ichiki（Niigata University, Graduate School of Medical and Dental Sciences）
Keisuke Yonehara（Research Organization of Information and Systems, National Institute of Genetics）
Ken-ichiro Nakajima（National Institute for Physiological Sciences）
Yu FU（Institute of Molecular and Cell Biology (IMCB) ）
Sensory functions and the autonomic nervous system cooperate in a mutual feedback loop to maintain homeostasis in the body. However, the basis of the neural circuit remains unclear. In this symposium, experts in various research fields, such as vision, taste, and visceral sensory reception by the autonomic nervous system, will gather to present the latest findings on the mechanisms underlying the sensory functions and neural circuit that cleverly maintain homeostasis in the body. The aim of this symposium is to facilitate interdisciplinary research collaborations in future by inviting young and up-and-coming speakers from Japan and abroad and providing them with opportunities for discussion.
3S08e

Frontiers in structure-based molecular physiology focusing on membrane transport proteins

Date：Mar 16　16:30 - 18:30　Place：Room 8
Organizer：
Haruo Ogawa（Graduate School of Pharmaceutical Sciences, Kyoto University）
Shushi Nagamori（Department of Laboratory Medicine, The Jikei University School of Medicine）
Katsumasa Irie（School of Pharmaceutical Sciences, Wakayama Medical University）
Go Kasuya（Division of Integrative Physiology, Department of Physiology, Jichi Medical University）
Pattama WIRIYASERMKUL（Department of Laboratory Medicine, The Jikei University School of Medicine）
Haruo Ogawa（Graduate School of Pharmaceutical Sciences, Kyoto University）
Takashi Murayama（Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine）
Membrane transport proteins have responsibilities for regulating chemical gradients across membranes. Recent revolution of cryo-electron microscopy has opened a door and let researchers step into a new world. We can analyze physiological functions of the proteins at the molecular level using the protein structures, while these remain challenging targets. In this symposium, five researchers, who study membrane transport proteins based on structural information, will share their experiences in dealing with the challenging subjects. The topics are selectivity of Ca2+ channels, opening mechanism of K+ channels, biosynthesis and transport mechanism of amino acid transporters, structure-based functional analysis on ryanodine receptors, and drug discovery based on the functional mechanism of ryanodine receptors.
3S09e

Mereological Neurophysiology

Date：Mar 16　16:30 - 18:30　Place：Room 9
Organizer：
Makoto Osanai（Osaka University）
Hajime Mushiake（Tohoku University）
Makoto Osanai（Osaka University）
Yuanyuan Guo（Tohoku University）
Yoshio Iguchi（Fukushima Medical University）
Noriaki Ohkawa（Dokkyo Medical University）
Kazuhiro Sakamoto（Tohoku Medical and Pharmaceutical University）
The brain and nervous system, which controls communication with the environment and other individuals, has a remarkably complex structural and functional hierarchy in the biological systems. Therefore, even if we precisely analyze a “part” of brain, such as a cell, we cannot elucidate the function expression mechanisms of the brain and nervous system. Conversely, even if we precisely measure the relationship between the input and output (i. e. phenotype), the brain remains a black box. Hence, since the brain and nervous system function through the interaction of the “whole” and its “parts,” to understand the brain and nervous system, unraveling their “parts and whole problem” (mereology) is needed. In this symposium, we will have talks on measurement philosophy, brain and neuroscience, and mereological thinking and discuss them.
3S10e

Inter-relation of biosensing functions and their role in the regulation of circulation during exercise

Date：Mar 16　16:30 - 18:30　Place：Room 10
Organizer：
Shigehiko Ogoh（Toyo University）
Jun Sugawara（National Institute of Advanced Industrial Science and Technology）
Kesho Katayama（Nagoya University）
Shigehiko Ogoh（Toyo University）
Manabu Shibasaki（Nara Women University）
Masaki Mizuno（University of Texas Southwestern Medical Center）
The circulatory system maintains its homeostasis through the autonomic nervous system. Physiological factors sensed in blood vessels and muscles, such as blood pressure, pH, blood oxygen/carbon dioxide partial pressure, muscle metabolism, muscle contraction, temperature, blood vessel shear rate (friction stimulation to the blood vessel wall), etc. are transferred to the central system as feedback information, and it as well as the brain activity affects the autonomic nerve activity. However, the contribution of the inter-relationships of each sensing function with brain activity to the circulatory system is complicated. In this symposium, we will focus on the interaction of sensing of each physiological function, and consider the effect on respiratory and circulatory diseases.

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